Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification

(2015) Takuya Kitamura et al.   BIOCHEMICAL JOURNAL

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

(2014) Takayuki Sassa et al.   Biomolecules & Therapeutics

Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

(2014) Natsuki Kondo et al.   Nature Communications

Formation and functions of the corneocyte lipid envelope (CLE)

(2013) Peter M. Elias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of lipoxygenases in epidermis

(2013) Peter Krieg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of sphingolipid metabolism in cutaneous permeabilitybarrier formation

(2013) Bernadette Breiden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lamellar ichthyosis in a collodion baby caused by CYP4F22 mutations in a non-consanguineous family outside the Mediterranean

(2013) Kazumitsu Sugiura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Impaired Epidermal Ceramide Synthesis Causes Autosomal Recessive Congenital Ichthyosis and Reveals the Importance of Ceramide Acyl Chain Length

(2013) Katja-Martina Eckl et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

(2013) T. Sassa et al.   MOLECULAR AND CELLULAR BIOLOGY

Very long-chain fatty acids: elongation, physiology and related disorders

(2012) A. Kihara   JOURNAL OF BIOCHEMISTRY

Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation

(2012) Peter Krieg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

(2012) Michelle Janssens et al.   JOURNAL OF LIPID RESEARCH

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Recessive Mutations in ELOVL4 Cause Ichthyosis, Intellectual Disability, and Spastic Quadriplegia

(2011) Mohammed A. Aldahmesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of ceramide synthase 3 causes lethal skin barrier disruption

(2011) Richard Jennemann et al.   HUMAN MOLECULAR GENETICS

Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation

(2011) Yuxiang Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in the Ceramide Profile of Atopic Dermatitis Patients

(2010) Junko Ishikawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

(2010) Y. Ohno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide biosynthesis in keratinocyte and its role in skin function

(2009) Yukiko Mizutani et al.   BIOCHIMIE

An update on molecular aspects of the non-syndromic ichthyoses

(2008) Masashi Akiyama et al.   EXPERIMENTAL DERMATOLOGY

Characterization of the human ω-oxidation pathway for ω-hydroxy-very-long-chain fatty acids

(2008) Robert-Jan Sanders et al.   FASEB JOURNAL

Membrane Topology and Essential Amino Acid Residues of Phs1, a 3-Hydroxyacyl-CoA Dehydratase Involved in Very Long-chain Fatty Acid Elongation

(2008) Akio Kihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omega-O-acylceramide, a lipid essential for mammalian survival

(2008) Yoshikazu Uchida et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Characterization of overall ceramide species in humanstratum corneum

(2008) Yoshinori Masukawa et al.   JOURNAL OF LIPID RESEARCH