Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain

Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger

(2012) Sun Hong Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats

(2012) An-hui Yao et al.   Evidence-based Complementary and Alternative Medicine

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

(2012) Takashi Shichita et al.   JOURNAL OF NEUROCHEMISTRY

The role of the immune system in the generation of neuropathic pain

(2012) Margarita Calvo et al.   LANCET NEUROLOGY

Streptozotocin-induced diabetic hyperalgesia in rats is associated with upregulation of toll-like receptor 4 expression

(2012) Jian-e Yan et al.   NEUROSCIENCE LETTERS

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain

(2011) Peter M. Grace et al.   BRAIN BEHAVIOR AND IMMUNITY

Rifampicin inhibits microglial inflammation and improves neuron survival against inflammation

(2011) Wei Bi et al.   BRAIN RESEARCH

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies

(2011) Amisha Barochia et al.   Expert Opinion on Drug Metabolism & Toxicology

Nonprofit disease groups earmark grants for drug repositioning

(2011) Elie Dolgin   NATURE MEDICINE

Signatures for drug repositioning

(2011) Charlotte Harrison   NATURE REVIEWS GENETICS

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

(2011) M. R. Hutchinson et al.   PHARMACOLOGICAL REVIEWS

Myeloid differentiation 2 as a therapeutic target of inflammatory disorders

(2011) Sun Hong Park et al.   PHARMACOLOGY & THERAPEUTICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Pregnane X Receptor PXR Activates theGADD45β Gene, Eliciting the p38 MAPK Signal and Cell Migration

(2010) Susumu Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Role of Rifaximin in Inflammatory Bowel Disease: Clinical Implication of Human Pregnane X Receptor Activation

(2010) J. Cheng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-κB DNA-binding Activity in RAW 264.7 Cells

(2010) Seong Keun Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2

(2009) Koji Kuronuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Taxanes inhibit human TLR4 signaling by binding to MD-2

(2008) Nuša Resman et al.   FEBS LETTERS

Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice

(2008) Isabella Bettoni et al.   GLIA

Paclitaxel Binding to Human and Murine MD-2

(2008) Shanta M. Zimmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE