Personal tumor antigens in blood malignancies: genomics-directed identification and targeting

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

(2019) Dyantha I. van der Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer

(2019) Livius Penter et al.   OncoImmunology

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma

(2019) Tanner M. Johanns et al.   OncoImmunology

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

Characterization and dynamics of specific T cells against nucleophosmin-1 (NPM1)-mutated peptides in patients with NPM1-mutated acute myeloid leukemia

(2019) Fabio Forghieri et al.   Oncotarget

Mutational Landscape of the Transcriptome Offers Putative Targets for Immunotherapy of Myeloproliferative Neoplasms

(2019) Fiorella Schischlik et al.   BLOOD

B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

(2019) Adam D. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

CD19 CAR T cell product and disease attributes predict leukemia remission durability

(2019) Olivia C. Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

(2019) Wei Yang et al.   NATURE MEDICINE

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

(2019) Noopur Raje et al.   NEW ENGLAND JOURNAL OF MEDICINE

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

RNase H–dependent PCR-enabled T-cell receptor sequencing for highly specific and efficient targeted sequencing of T-cell receptor mRNA for single-cell and repertoire analysis

(2019) Shuqiang Li et al.   Nature Protocols

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

(2019) Anthony E. Zamora et al.   Science Translational Medicine

Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T Cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms

(2019) Cansu Cimen Bozkus et al.   Cancer Discovery

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes

(2019) Tomasz Kula et al.   CELL

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

(2019) Sara Ghorashian et al.   NATURE MEDICINE

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 + T Cells During Relapse after Allogeneic Stem Cell Transplantation

(2018) Tim J.A. Hutten et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

(2018) Marvin H. Gee et al.   CELL

FACS single cell index sorting is highly reliable and determines immune phenotypes of clonally expanded T cells

(2018) Livius Penter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

(2018) Bertram Bengsch et al.   IMMUNITY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I

(2018) Najla Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nivolumab for Relapsed/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial

(2018) Philippe Armand et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report

(2018) Katja Sonntag et al.   Journal of Translational Medicine

We skip to work: alternative splicing in normal and malignant myelopoiesis

(2018) Alex C. H. Wong et al.   LEUKEMIA

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors

(2018) Yong-Chen Lu et al.   MOLECULAR THERAPY

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

(2018) Alessandro Prestipino et al.   Science Translational Medicine

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

(2018) Vanessa M. Tubb et al.   Journal for ImmunoTherapy of Cancer

Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors Before and After Allogeneic transplantation

(2018) Awais Ijaz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A cloning and expression system to probe T cell receptor specificity and assess functional avidity to neoantigens

(2018) Zhuting Hu et al.   BLOOD

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination

(2018) Yasushi Akahori et al.   BLOOD

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

(2018) André Kahles et al.   CANCER CELL

Abstract CT032: Adoptive T cell transfer combined with DC vaccination in patients with metastatic melanoma

(2018) stina L. wickström et al.   CANCER RESEARCH

Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging

(2018) Yury Goltsev et al.   CELL

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

1127OA personal neoantigen vaccine, NEO-PV-01, with anti-PD1 induces broad de novo anti-tumor immunity in patients with metastatic melanoma, NSCLC, and bladder cancer

(2018) P A Ott et al.   ANNALS OF ONCOLOGY

B cell lymphomas present immunoglobulin neoantigens

(2018) Michael S. Khodadoust et al.   BLOOD

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

(2018) Derin B. Keskin et al.   NATURE

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

(2018) Wouter Scheper et al.   NATURE MEDICINE

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

(2018) Matthew J. Christopher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

The calreticulin (CALR) exon 9 mutations are promising targets for cancer immune therapy

(2017) M O Holmström et al.   LEUKEMIA

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

(2017) Michael S. Khodadoust et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

(2017) Richard M. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

(2017) Moshe Sade-Feldman et al.   Nature Communications

Coevolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia

(2017) Noelia Purroy et al.   Cold Spring Harbor Perspectives in Medicine

The neoepitope landscape in pediatric cancers

(2017) Ti-Cheng Chang et al.   Genome Medicine

Clonal Expansion and Interrelatedness of Distinct B-Lineage Compartments in Multiple Myeloma Bone Marrow

(2017) Leo Hansmann et al.   Cancer Immunology Research

Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia

(2017) Stacy A. Malaker et al.   Cancer Immunology Research

Identifying Leukemia-Specific Neoepitopes from Next-Generation Sequencing Data to Develop Targeted Immunotherapy for Pediatric Acute Myeloid Leukemiaig

(2016) Melinda Ann Biernacki et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

BCR-ABL–specific T-cell therapy in Ph+ALL patients on tyrosine-kinase inhibitors

(2016) Patrizia Comoli et al.   BLOOD

PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR

(2016) Elise A. Chong et al.   BLOOD

Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma

(2016) Rodney R. Miles et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia

(2016) Lili Wang et al.   CANCER CELL

Integrated Whole Genome and Transcriptome Analysis Identified a Therapeutic Minor Histocompatibility Antigen in a Splice Variant ofITGB2

(2016) Margot J. Pont et al.   CLINICAL CANCER RESEARCH

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial

(2016) Anas Younes et al.   LANCET ONCOLOGY

The JAK2V617F mutation is a target for specific T cells in the JAK2V617F-positive myeloproliferative neoplasms

(2016) M O Holmström et al.   LEUKEMIA

Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers

(2016) D P Granados et al.   LEUKEMIA

The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms

(2016) M O Holmström et al.   LEUKEMIA

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Tyrosine kinase inhibitors in chronic myeloid leukaemia: which, when, for whom?

(2016) Gianantonio Rosti et al.   Nature Reviews Clinical Oncology

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

(2016) Matthew S. Davids et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions

(2016) J. Rosenblatt et al.   Science Translational Medicine

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

(2016) Marieke Griffioen et al.   Frontiers in Immunology

Targeting B-cell malignancies through human B-cell receptor specific CD4+ T cells

(2016) Jinsheng Weng et al.   OncoImmunology

HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy

(2016) Annika Nelde et al.   OncoImmunology

Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification

(2015) P. Strati et al.   BLOOD

The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell-based immunotherapy

(2015) S. Walz et al.   BLOOD

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells

(2015) J. S. Nielsen et al.   CLINICAL CANCER RESEARCH

LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application

(2015) M. J. Pont et al.   HAEMATOLOGICA

Tumor neoantigens: building a framework for personalized cancer immunotherapy

(2015) Matthew M. Gubin et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations driving CLL and their evolution in progression and relapse

(2015) Dan A. Landau et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application

(2015) M. J. Pont et al.   HAEMATOLOGICA

A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia

(2014) A. V. Moorman et al.   BLOOD

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

(2014) M. Rajasagi et al.   BLOOD

CD20 alternative splicing isoform generates immunogenic CD4 helper T epitopes

(2014) Charline Vauchy et al.   INTERNATIONAL JOURNAL OF CANCER

Active Idiotypic Vaccination Versus Control Immunotherapy for Follicular Lymphoma

(2014) Ronald Levy et al.   JOURNAL OF CLINICAL ONCOLOGY

Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor

(2014) S. Wilkie et al.   JOURNAL OF IMMUNOLOGY

Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy

(2014) C Berlin et al.   LEUKEMIA

Linking T-cell receptor sequence to functional phenotype at the single-cell level

(2014) Arnold Han et al.   NATURE BIOTECHNOLOGY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL)

(2014) Daniel J. Kowalewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse after Hematopoietic Stem Cell Transplantation: Part I. Biology of Relapse after Transplantation

(2013) Ronald E. Gress et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Multicenter Analyses Demonstrate Significant Clinical Effects of Minor Histocompatibility Antigens on GvHD and GvL after HLA-Matched Related and Unrelated Hematopoietic Stem Cell Transplantation

(2013) Eric Spierings et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms

(2013) M. Varettoni et al.   BLOOD

EZH2 mutations are frequent and represent an early event in follicular lymphoma

(2013) C. Bodor et al.   BLOOD

Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion

(2013) P. Bachireddy et al.   BLOOD

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)

(2013) J. Greiner et al.   BLOOD

Autologous CLL cell vaccination early after transplant induces leukemia-specific T cells

(2013) Ute E. Burkhardt et al.   JOURNAL OF CLINICAL INVESTIGATION

MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia

(2013) M. Cobbold et al.   Science Translational Medicine

Transferred WT1-Reactive CD8+ T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients

(2013) A. G. Chapuis et al.   Science Translational Medicine

Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients

(2012) M Foglietta et al.   BONE MARROW TRANSPLANTATION

Constitutive AP-1 Activity and EBV Infection Induce PD-L1 in Hodgkin Lymphomas and Posttransplant Lymphoproliferative Disorders: Implications for Targeted Therapy

(2012) M. R. Green et al.   CLINICAL CANCER RESEARCH

Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients

(2012) A. Cai et al.   CLINICAL CANCER RESEARCH

Donor Lymphocyte Infusion Induces Polyspecific CD8+T-Cell Responses With Concurrent Molecular Remission in Acute Myeloid Leukemia WithNPM1Mutation

(2012) Susanne Hofmann et al.   JOURNAL OF CLINICAL ONCOLOGY

Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1

(2012) R Oostvogels et al.   LEUKEMIA

Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia

(2012) S Anguille et al.   LEUKEMIA

Detecting T-cell reactivity to whole cell vaccines

(2012) Ana Brusic et al.   OncoImmunology

The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed

(2011) J. Popovic et al.   BLOOD

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

(2011) Marie Bleakley et al.   IMMUNOLOGY AND CELL BIOLOGY

Vaccination With Patient-Specific Tumor-Derived Antigen in First Remission Improves Disease-Free Survival in Follicular Lymphoma

(2011) Stephen J. Schuster et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-1 Blockade by CT-011, Anti-PD-1 Antibody, Enhances Ex Vivo T-cell Responses to Autologous Dendritic Cell/Myeloma Fusion Vaccine

(2011) Jacalyn Rosenblatt et al.   JOURNAL OF IMMUNOTHERAPY

Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells

(2010) M. Bleakley et al.   BLOOD

Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens

(2010) E. H. Warren et al.   BLOOD

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells

(2010) W. Hobo et al.   BLOOD

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

(2010) M. R. Green et al.   BLOOD

High-Throughput Characterization of 10 New Minor Histocompatibility Antigens by Whole Genome Association Scanning

(2010) C. A. M. Van Bergen et al.   CANCER RESEARCH

Expression of aberrantly glycosylated Mucin-1 in ovarian cancer

(2010) Catharina H M J Van Elssen et al.   HISTOPATHOLOGY

Graft-versus-host driven graft-versus-leukemia effect of minor histocompatibility antigen HA-1 in chronic myeloid leukemia patients

(2010) T Mutis et al.   LEUKEMIA

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emergence of BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment

(2009) G. Riva et al.   BLOOD

Placebo-Controlled Phase III Trial of Patient-Specific Immunotherapy With Mitumprotimut-T and Granulocyte-Macrophage Colony-Stimulating Factor After Rituximab in Patients With Follicular Lymphoma

(2009) Arnold Freedman et al.   JOURNAL OF CLINICAL ONCOLOGY

Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation

(2009) V. T. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular biology of bcr-abl1-positive chronic myeloid leukemia

(2008) A. Quintas-Cardama et al.   BLOOD

Graft-versus-leukemia effects of transplantation and donor lymphocytes

(2008) H.-J. Kolb   BLOOD