Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

(2018) De-Liang Zhang et al.   SCIENCE

Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress

(2018) De-Liang Zhang et al.   BLOOD

Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia

(2018) Stefano Rivella   BLOOD

Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload

(2018) Andrew J. Schwartz et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

(2017) Ramasamy Jagadeeswaran et al.   EXPERIMENTAL HEMATOLOGY

From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals

(2017) Martina Moras et al.   Frontiers in Physiology

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Mitochondrial Changes in β0-Thalassemia/Hb E Disease

(2016) Kornpat Khungwanmaythawee et al.   PLoS One

 -Globin as a molecular target in the treatment of  -thalassemia

(2015) S. Mettananda et al.   BLOOD

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

(2015) Kristoff A. Olson et al.   EUROPEAN HEART JOURNAL

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous b1/b2 globin gene deletion) mice

(2015) M. P. Gelderman et al.   HAEMATOLOGICA

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

(2015) Reiya Taniguchi et al.   Nature Communications

 -thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

(2015) S. Rivella   HAEMATOLOGICA

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous b1/b2 globin gene deletion) mice

(2015) M. P. Gelderman et al.   HAEMATOLOGICA

Oxidative stress in β-thalassaemia and sickle cell disease

(2015) S. Voskou et al.   Redox Biology

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine  -thalassemia

(2014) R. N. V. S. Suragani et al.   BLOOD

A structural model of human ferroportin and of its iron binding site

(2014) Maria C. Bonaccorsi di Patti et al.   FEBS Journal

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with  -thalassemia major: a longitudinal study

(2013) S.-R. Pasricha et al.   BLOOD

Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis

(2013) J. Liu et al.   BLOOD

The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

(2013) Sheila A. Anderson et al.   Cell Metabolism

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia

(2012) Stefano Rivella   BLOOD REVIEWS

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination

(2012) Bo Qiao et al.   Cell Metabolism

Increased oxidative metabolism is associated with erythroid precursor expansion in β0-thalassaemia/Hb E disease

(2011) Amporn Leecharoenkiat et al.   BLOOD CELLS MOLECULES AND DISEASES

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

(2010) Jim J. Xiao et al.   AAPS Journal

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

High nontransferrin bound iron levels and heart disease in thalassemia major

(2008) Antonio Piga et al.   AMERICAN JOURNAL OF HEMATOLOGY

Controlling  -globin: a review of  -globin expression and its impact on  -thalassemia

(2008) H. P. J. Voon et al.   HAEMATOLOGICA

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE