H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

(2019) Choong-kun Lee et al.   SCIENCE

The Clinical Trial Landscape for Melanoma Therapies

(2019) Sonia Wróbel et al.   Journal of Clinical Medicine

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

(2018) Daniel Zingg et al.   CANCER CELL

The Heterochromatin Landscape in Migrating Cells and the Importance of H3K27me3 for Associated Transcriptome Alterations

(2018) Tamar Segal et al.   Cells

ERRα Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1α-Elevated Melanomas

(2017) Chi Luo et al.   MOLECULAR CANCER RESEARCH

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

The state of melanoma: challenges and opportunities

(2016) Glenn Merlino et al.   Pigment Cell & Melanoma Research

The Trans-Spliced Long Noncoding RNA tsRMST Impedes Human Embryonic Stem Cell Differentiation Through WNT5A-Mediated Inhibition of the Epithelial-to-Mesenchymal Transition

(2016) Chun-Ying Yu et al.   STEM CELLS

Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma

(2016) Jessamy Tiffen et al.   NEOPLASIA

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

The hitchhiker’s guide to PGC-1α isoform structure and biological functions

(2015) Vicente Martínez-Redondo et al.   DIABETOLOGIA

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

(2015) M. H. Kim et al.   EMBO JOURNAL

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Expression of oncogenic BRAFV600Ein melanocytes induces Schwannian differentiationin vivo

(2015) Chi Luo et al.   Pigment Cell & Melanoma Research

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

(2015) Daniel Zingg et al.   Nature Communications

Targeting Mitochondrial Oxidative Metabolism in Melanoma Causes Metabolic Compensation through Glucose and Glutamine Utilization

(2014) J.-H. Lim et al.   CANCER RESEARCH

MITF in melanoma: mechanisms behind its expression and activity

(2014) Mariusz L. Hartman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcription of Angiogenin and Ribonuclease 4 Is Regulated by RNA Polymerase III Elements and a CCCTC Binding Factor (CTCF)-dependent Intragenic Chromatin Loop

(2014) Jinghao Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

(2014) Jamie N. Anastas et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells

(2014) C S Manning et al.   ONCOGENE

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Loss of ARF Sensitizes Transgenic BRAFV600E Mice to UV-Induced Melanoma via Suppression of XPC

(2013) C. Luo et al.   CANCER RESEARCH

The BRAFV600E causes widespread alterations in gene methylation in the genome of melanoma cells

(2012) Peng Hou et al.   CELL CYCLE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Frequent mutations in the MITF pathway in melanoma

(2009) Julia C. Cronin et al.   Pigment Cell & Melanoma Research

A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion

(2009) V. Jenei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH