TRP channels as therapeutic targets in airway disorders: a patent review

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

(2012) Raul R. Calvo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

(2012) Jay M. Matthews et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

(2012) Nuria A. Tamayo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Mucosal TRPV1 Inhibition in Allergic Rhinitis

(2011) Lisa Alenmyr et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists

(2011) Harrie J.M. Gijsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transient Receptor Potential A1 Channels

(2011) Maria G. Belvisi et al.   CHEST

WHO universal definition of severe asthma

(2011) Andrew Bush et al.   Current Opinion in Allergy and Clinical Immunology

TRPM8 Biology and Medicinal Chemistry

(2011) Jeff DeFalco et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

(2011) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist

(2011) Michael P. Maher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hydrogen Sulfide Upregulates Cyclooxygenase-2 and Prostaglandin E Metabolite in Sepsis-Evoked Acute Lung Injury via Transient Receptor Potential Vanilloid Type 1 Channel Activation

(2011) S.-F. Ang et al.   JOURNAL OF IMMUNOLOGY

Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells

(2011) Indranil Mukhopadhyay et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

TRP channels: Emerging targets for respiratory disease

(2011) Katharine Helen Banner et al.   PHARMACOLOGY & THERAPEUTICS

Sensing pulmonary oxidative stress by lung vagal afferents

(2011) Thomas E. Taylor-Clark et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

A role for sensory nerves in the late asthmatic response

(2011) Kristof Raemdonck et al.   THORAX

New therapeutic options in the management of COPD – focus on roflumilast

(2011) Sabina Antoniu   International Journal of Chronic Obstructive Pulmonary Disease

5-Benzyloxytryptamine as an antagonist of TRPM8

(2010) Jeff DeFalco et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

(−)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels

(2010) Giorgio Ortar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analogues of Morphanthridine and the Tear Gas Dibenz[b,f][1,4]oxazepine (CR) as Extremely Potent Activators of the Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channel

(2010) Harrie J. M. Gijsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents

(2010) Pier Giovanni Baraldi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

(2010) Daniel J. Parks et al.   JOURNAL OF MEDICINAL CHEMISTRY

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor

(2009) Jeff DeFalco et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents

(2009) E Andrè et al.   BRITISH JOURNAL OF PHARMACOLOGY

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

On the putative role of transient receptor potential cation channels in asthma

(2009) B. Colsoul et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Occupational asthma: Current concepts in pathogenesis, diagnosis, and management

(2009) Mark S. Dykewicz   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

(2009) T. E. Taylor-Clark et al.   MOLECULAR PHARMACOLOGY

Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats

(2009) S. Peles et al.   NEUROSCIENCE

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The calcium-conducting ion channel transient receptor potential canonical 6 is involved in macrophage inflammatory protein-2-induced migration of mouse neutrophils

(2008) N. Damann et al.   Acta Physiologica

Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures

(2008) Ashwini S. Sabnis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists

(2008) Laxmikant A Gharat et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

(2008) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

New targets for drug development in asthma

(2008) Ian M Adcock et al.   LANCET

TRPM8 Mechanism of Autonomic Nerve Response to Cold in Respiratory Airway

(2008) Hong Xing et al.   Molecular Pain

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Does inhaling menthol affect nasal patency or cough?

(2008) Priti Kenia et al.   PEDIATRIC PULMONOLOGY