New insights into pharmacological tools to TR(i)P cancer up

The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker

(2013) Byung J. Kim et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?

(2013) Robin S Bon et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade

(2013) G. Trevisan et al.   CANCER RESEARCH

Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain

(2013) A. Guilbert et al.   EUROPEAN JOURNAL OF CANCER

Targeting TRP channels for pain relief

(2013) Jill-Desiree Brederson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx

(2013) Jeong Ah Hwang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In Vivo Detection of Human TRPV6-Rich Tumors with Anti-Cancer Peptides Derived from Soricidin

(2013) Chris V. Bowen et al.   PLoS One

Involvement of TRPC Channels in Lung Cancer Cell Differentiation and the Correlation Analysis in Human Non-Small Cell Lung Cancer

(2013) Hong-Ni Jiang et al.   PLoS One

TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion

(2013) Agathe Oulidi et al.   PLoS One

Targeting Calcium Channels to Block Tumor Vascularization

(2013) Luca Munaron et al.   Recent Patents on Anti-Cancer Drug Discovery

Involvement of melastatin type transient receptor potential 7 channels in ginsenoside Rd-induced apoptosis in gastric and breast cancer cells

(2013) Byung Joo Kim   Journal of Ginseng Research

Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells

(2012) Eva A.M. Schaefer et al.   BIOCHEMICAL PHARMACOLOGY

The functions of TRPA1 and TRPV1: moving away from sensory nerves

(2012) ES Fernandes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

(2012) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1 channels in the vasculature

(2012) Scott Earley   BRITISH JOURNAL OF PHARMACOLOGY

TRPM7 Is Required for Breast Tumor Cell Metastasis

(2012) Jeroen Middelbeek et al.   CANCER RESEARCH

Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents

(2012) Massimo Nabissi et al.   CARCINOGENESIS

TRP channels as therapeutic targets in airway disorders: a patent review

(2012) Delia Preti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS–JNK–CHOP-mediated upregulation of death receptors

(2012) Bokyung Sung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

(2012) Pierre Rybarczyk et al.   INTERNATIONAL JOURNAL OF CANCER

The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation

(2012) Maria Beatrice Morelli et al.   INTERNATIONAL JOURNAL OF CANCER

The role of the TRPV6 channel in cancer

(2012) V’yacheslav Lehen’kyi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

(2012) Kristin Stock et al.   NATURE MEDICINE

TRPM8 Ion Channels Differentially Modulate Proliferation and Cell Cycle Distribution of Normal and Cancer Prostate Cells

(2012) María Ll. Valero et al.   PLoS One

TRP channels: diagnostic markers and therapeutic targets for breast cancer?

(2012) Halima Ouadid-Ahidouch et al.   TRENDS IN MOLECULAR MEDICINE

TRP Channels and Cancer: New Targets for Diagnosis and Chemotherapy

(2012) Giorgio Santoni et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

TRP channels in prostate cancer: the good, the bad and the ugly?

(2011) Dimitra Gkika et al.   ASIAN JOURNAL OF ANDROLOGY

Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae ): evidence for TRPA1-independent effects

(2011) Raffaele Capasso et al.   BRITISH JOURNAL OF PHARMACOLOGY

The thermo-TRP ion channel family: properties and therapeutic implications

(2011) Laura Vay et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Two Faces of Capsaicin

(2011) A. M. Bode et al.   CANCER RESEARCH

Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells

(2011) Sara Caprodossi et al.   CARCINOGENESIS

TRP channels in cell survival and cell death in normal and transformed cells

(2011) George Shapovalov et al.   CELL CALCIUM

Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials

(2011) Igor Kissin et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacology of transient receptor potential melastatin channels in the vasculature

(2010) Alexander Zholos   BRITISH JOURNAL OF PHARMACOLOGY

The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels

(2010) A Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Phase I study of paclitaxel and continuous daily CAI in patients with refractory solid tumors

(2010) Nilofer Azad et al.   CANCER BIOLOGY & THERAPY

Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas

(2010) V. C. Bomben et al.   CELL PROLIFERATION

Targeting TRPC6 channels in oesophageal carcinoma growth

(2010) Xia Ding et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas

(2010) Valerie C. Bomben et al.   GLIA

Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas

(2010) Valerie C. Bomben et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma

(2010) Xia Ding et al.   JNCI-Journal of the National Cancer Institute

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

Pharmacological and functional properties of TRPM8 channels in prostate tumor cells

(2010) Maria Valero et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Evidence that TRPM7 is required for breast cancer cell proliferation

(2009) Arnaud Guilbert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

(2009) Robert Ramer et al.   BIOCHEMICAL PHARMACOLOGY

Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation

(2009) Michaël Monet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner

(2009) C. Amantini et al.   CARCINOGENESIS

Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer

(2009) Y Shi et al.   GUT

Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells

(2009) Rong Cai et al.   INTERNATIONAL JOURNAL OF CANCER

The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not

(2009) A. A. Romanovsky et al.   PHARMACOLOGICAL REVIEWS

Production of a specific extracellular inhibitor of TRPM3 channels

(2008) J Naylor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vanilloid Transient Receptor Potential Cation Channels: An Overview

(2008) Bernd Nilius et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1

(2007) Robert Ramer et al.   JNCI-Journal of the National Cancer Institute

Phase III randomized, double-blind study of maintenance CAI or placebo in patients with advanced non-small cell lung cancer (NSCLC) after completion of initial therapy (NCCTG 97-24-51)

(2007) Elizabeth A. Johnson et al.   LUNG CANCER