The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC): IUPHAR Review 19

Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids

(2016) S. Marra et al.   EMBO JOURNAL

Cystic Fibrosis

(2016) Marie-Luise Brennan et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Optogenetic approaches addressing extracellular modulation of neural excitability

(2016) Emily A. Ferenczi et al.   Scientific Reports

Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms

(2016) Ming-Gang Liu et al.   Scientific Reports

New Insights about miRNAs in Cystic Fibrosis

(2015) Florence Sonneville et al.   AMERICAN JOURNAL OF PATHOLOGY

Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels

(2015) Pia Jeggle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Epidemiology of Blood Pressure and Its Worldwide Management

(2015) K. Rahimi et al.   CIRCULATION RESEARCH

Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice

(2015) Sophia N Verouti et al.   CURRENT OPINION IN PHARMACOLOGY

Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety

(2015) Shing-Hong Lin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Proteolytic Regulation of Epithelial Sodium Channels by Urokinase Plasminogen Activator

(2015) Hong-Long Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels

(2015) Stephan Kellenberger et al.   JOURNAL OF MOLECULAR BIOLOGY

Extracellular pH Regulates Excitability of Vomeronasal Sensory Neurons

(2015) A. Cichy et al.   JOURNAL OF NEUROSCIENCE

Autocrine Boost of NMDAR Current in Hippocampal CA1 Pyramidal Neurons by a PMCA-Dependent, Perisynaptic, Extracellular pH Shift

(2015) H.-Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons

(2015) Patrice Quintana et al.   JOURNAL OF PHYSIOLOGY-LONDON

The dichotomized role for acid sensing ion channels in musculoskeletal pain and inflammation

(2015) Kathleen A. Sluka et al.   NEUROPHARMACOLOGY

ASICs and mammalian mechanoreceptor function

(2015) Damir Omerbašić et al.   NEUROPHARMACOLOGY

Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems

(2015) Emmanuel Deval et al.   NEUROPHARMACOLOGY

ASICs and neuropeptides

(2015) Jonathan S. Vick et al.   NEUROPHARMACOLOGY

Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

(2015) Anne Baron et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

ENaC activity in collecting ducts modulates NCC in cirrhotic mice

(2015) David Mordasini et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The hidden hand of chloride in hypertension

(2015) Linsay McCallum et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Epithelial Sodium Transport and Its Control by Aldosterone: The Story of Our Internal Environment Revisited

(2015) Bernard C. Rossier et al.   PHYSIOLOGICAL REVIEWS

Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4

(2015) Anna Keppner et al.   PLoS One

ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory

(2015) Po-Han Chiang et al.   Scientific Reports

ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand

(2015) Zhong Peng et al.   Cell Reports

Therapeutic Effects of α1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice

(2015) David P. Nichols et al.   PLoS One

Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling

(2015) Wei-Zheng Zeng et al.   Scientific Reports

Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency

(2014) Zaixing Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

(2014) Isabelle Baconguis et al.   CELL

Collecting Duct Principal Cell Transport Processes and Their Regulation

(2014) D. Pearce et al.   Clinical Journal of the American Society of Nephrology

The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition

(2014) Giovanna Crisante et al.   FASEB JOURNAL

A Method for Activation of Endogenous Acid-sensing Ion Channel 1a (ASIC1a) in the Nervous System with High Spatial and Temporal Precision

(2014) Tianbo Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites

(2014) Silke Haerteis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a

(2014) Miguel Salinas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new life for an old pump: V-ATPase and neurotransmitter release

(2014) Stefano Vavassori et al.   JOURNAL OF CELL BIOLOGY

The Evolving Clinical Management of Hypertension

(2014) Michael A. Weber   Journal of Clinical Hypertension

Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro

(2014) Kristian B. Buhl et al.   JOURNAL OF HYPERTENSION

ASIC1a Activation Enhances Inhibition in the Basolateral Amygdala and Reduces Anxiety

(2014) V. I. Pidoplichko et al.   JOURNAL OF NEUROSCIENCE

Functional coupling of renal K+and Na+handling causes high blood pressure in Na+replete mice

(2014) Helga Vitzthum et al.   JOURNAL OF PHYSIOLOGY-LONDON

Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance

(2014) S. Malsure et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Renal Control of Potassium Homeostasis in Complete Aldosterone Deficiency

(2014) A. Todkar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Epithelial Sodium Channel  -Subunit Is Processed Proteolytically in Human Kidney

(2014) R. M. Zachar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons

(2014) Aurélien Boillat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

(2014) Collin J Kreple et al.   NATURE NEUROSCIENCE

The CNS under pathophysiologic attack—examining the role of K2P channels

(2014) Petra Ehling et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain

(2014) Alistair Mathie et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of the Epithelial Sodium Channel (ENaC) by Bacterial Metalloproteases and Protease Inhibitors

(2014) Michael B. Butterworth et al.   PLoS One

Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry

(2014) T. Bartoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala

(2014) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that protons act as neurotransmitters at vestibular hair cell-calyx afferent synapses

(2014) S. M. Highstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

(2014) Ayla Valinezhad Orang et al.   International Journal of Genomics

Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

(2013) Carey A. Hobbs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-Induced Inhibition of Epithelial Na+Channels in the Lung. Role of Nedd4-2 and the Ubiquitin-Proteasome Pathway

(2013) Thomas Gille et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2

(2013) Christina I. Schroeder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC

(2013) Dominik Wiemuth et al.   Channels

The epithelial Na+ channel

(2013) Kristina Kusche-Vihrog et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Epithelial sodium channel (ENaC) and the control of blood pressure

(2013) Bernard C Rossier   CURRENT OPINION IN PHARMACOLOGY

Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: Importance in the control of blood pressure and hypertension

(2013) Bernard C. Rossier et al.   FEBS LETTERS

Epithelial Sodium Channel Stiffens the Vascular Endothelium In Vitro and in Liddle Mice

(2013) Pia Jeggle et al.   HYPERTENSION

Chronic Angiotensin II Infusion Drives Extensive Aldosterone-Independent Epithelial Na + Channel Activation

(2013) Mykola Mamenko et al.   HYPERTENSION

The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes

(2013) H.-y. Yang et al.   JOURNAL OF CELL SCIENCE

Neurosensory mechanotransduction through acid-sensing ion channels

(2013) Chih-Cheng Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Serotonin Facilitates Peripheral Pain Sensitivity in a Manner That Depends on the Nonproton Ligand Sensing Domain of ASIC3 Channel

(2013) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Acid-Sensing Ion Channel-1a Is Not Required for Normal Hippocampal LTP and Spatial Memory

(2013) P.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice

(2013) Mads V. Sorensen et al.   KIDNEY INTERNATIONAL

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels

(2013) Anne Baron et al.   TOXICON

Acid-sensing ion channels: trafficking and synaptic function

(2013) Xiang-ming Zha   Molecular Brain

ENaC Regulation by Proteases and Shear Stress

(2013) Shujie Shi et al.   Current Molecular Pharmacology

Advances in WNK Signaling of Salt and Potassium Metabolism: Clinical Implications

(2012) Juan Pablo Arroyo et al.   AMERICAN JOURNAL OF NEPHROLOGY

Mutations of the Serine Protease CAP1/Prss8 Lead to Reduced Embryonic Viability, Skin Defects, and Decreased ENaC Activity

(2012) Simona Frateschi et al.   AMERICAN JOURNAL OF PATHOLOGY

Regional differences in rat conjunctival ion transport activities

(2012) Dongfang Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

(2012) Marie-Louise Zani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Energetic and Structural Basis for Activation of the Epithelial Sodium Channel by Matriptase

(2012) Pradeep Kota et al.   BIOCHEMISTRY

Toxin binding reveals two open state structures for one acid-sensing ion channel

(2012) Stefan Gründer et al.   Channels

Neuropeptides and Neuropeptide Receptors: Drug Targets, and Peptide and Non-Peptide Ligands: a Tribute to Prof.Dieter Seebach

(2012) Daniel Hoyer et al.   CHEMISTRY & BIODIVERSITY

Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron

(2012) Nils van der Lubbe et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins

(2012) Steve Peigneur et al.   FASEB JOURNAL

Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1

(2012) Florian Lang et al.   FASEB JOURNAL

Subtype-specific Modulation of Acid-sensing Ion Channel (ASIC) Function by 2-Guanidine-4-methylquinazoline

(2012) Omar Alijevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Epithelial Sodium Channel (ENaC) by the Alkaline Protease fromPseudomonas aeruginosa

(2012) Michael B. Butterworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Channels and Mammalian Sensory Mechanotransduction

(2012) Ramin Raouf et al.   Molecular Pain

Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes

(2012) Isabelle Baconguis et al.   NATURE

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

(2012) Silke Haerteis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

(2012) Sinyoung Kang et al.   PLoS One

Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

(2012) A. Delaunay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA network regulates expression and biosynthesis of wild-type and  F508 mutant cystic fibrosis transmembrane conductance regulator

(2012) S. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aldosterone-independent regulation of the epithelial Na+ channel (ENaC) by vasopressin in adrenalectomized mice

(2012) E. Mironova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

(2012) Roger J.P. Dawson et al.   Nature Communications

Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation

(2012) Roman Szabo et al.   PLoS Genetics

A Role for K2P Channels in the Operation of Somatosensory Nociceptors

(2012) Leigh D. Plant   Frontiers in Molecular Neuroscience

Acidosis Differentially Modulates Inactivation in NaV1.2, NaV1.4, and NaV1.5 Channels

(2012) Yury Y. Vilin et al.   Frontiers in Pharmacology

Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes

(2011) Niren Kapoor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Inhibition of voltage-gated Na+ currents in sensory neurones by the sea anemone toxin APETx2

(2011) Maxime G Blanchard et al.   BRITISH JOURNAL OF PHARMACOLOGY

The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease

(2011) Zhe Zhou et al.   Journal of Cystic Fibrosis

The DEG/ENaC Protein MEC-10 Regulates the Transduction Channel Complex in Caenorhabditis elegans Touch Receptor Neurons

(2011) J. Arnadottir et al.   JOURNAL OF NEUROSCIENCE

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

(2011) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Acid-Sensing Ion Channels in Postoperative Pain

(2011) E. Deval et al.   JOURNAL OF NEUROSCIENCE

Non-genomic actions of aldosterone: From receptors and signals to membrane targets

(2011) Ruth Dooley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

(2011) Christopher J. Bohlen et al.   NATURE

TRPV1, TRPA1, and CB1 in the isolated vagus nerve – Axonal chemosensitivity and control of neuropeptide release

(2011) K. Weller et al.   NEUROPEPTIDES

Molecular Physiology of pH-Sensitive Background K2P Channels

(2011) Florian Lesage et al.   PHYSIOLOGY

Aldosterone Paradox: Differential Regulation of Ion Transport in Distal Nephron

(2011) Juan Pablo Arroyo et al.   PHYSIOLOGY

Morphological analysis of the trachea and pattern of breathing in βENaC-Tg mice

(2011) M. Bonora et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

(2011) Simona Frateschi et al.   Nature Communications

Secretory Leukocyte Protease Inhibitor and Elafin/Trappin-2

(2010) Jean-Michel Sallenave   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

High concentration electrophysiology-based fragment screen: Discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors

(2010) Scott E. Wolkenberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of the epithelial sodium channel by the metalloprotease meprin β subunit

(2010) Agustin Garcia-Caballero et al.   Channels

SerpinB1 in cystic fibrosis airway fluids: quantity, molecular form and mechanism of elastase inhibition

(2010) J. Cooley et al.   EUROPEAN RESPIRATORY JOURNAL

Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways

(2010) Xiao-Qing Pan et al.   EXPERIMENTAL NEUROLOGY

Constraint-based, Homology Model of the Extracellular Domain of the Epithelial Na+Channel α Subunit Reveals a Mechanism of Channel Activation by Proteases

(2010) Ossama B. Kashlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Cleavage of Human Acid-sensing Ion Channel 1 by the Serine Protease Matriptase

(2010) Edlira B. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice

(2010) Marcus A. Mall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

(2010) Françoise Leviel et al.   JOURNAL OF CLINICAL INVESTIGATION

Synaptic Acidification Enhances GABAA Signaling

(2010) C. J. Dietrich et al.   JOURNAL OF NEUROSCIENCE

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification

(2010) John G. Starkus et al.   JOURNAL OF PHYSIOLOGY-LONDON

 ENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus

(2010) B. M. Christensen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Type I and Type II Pseudohypoaldosteronism

(2010) S. B. Furgeson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sodium and Potassium Balance Depends on  ENaC Expression in Connecting Tubule

(2010) B. M. Christensen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The cells and peripheral representation of sodium taste in mice

(2010) Jayaram Chandrashekar et al.   NATURE

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

(2010) Ye Yu et al.   NEURON

Sensing Muscle Ischemia: Coincident Detection of Acid and ATP via Interplay of Two Ion Channels

(2010) William T. Birdsong et al.   NEURON

Diarylamidines: High potency inhibitors of acid-sensing ion channels

(2010) Xuanmao Chen et al.   NEUROPHARMACOLOGY

Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage

(2010) Jingjing Su et al.   NEUROSCIENCE LETTERS

Dietary Pattern and Hypertension: The DASH Study

(2010) B. Zemel   NUTRITION REVIEWS

Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity

(2010) Maxime G. Blanchard et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of signal transduction by calcitonin gene-related peptide receptors

(2010) Christopher S Walker et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis, Structure−Activity Relationship, and Pharmacological Profile of Analogs of The ASIC-3 Inhibitor A-317567

(2009) Scott D. Kuduk et al.   ACS Chemical Neuroscience

α1-Antitrypsin Inhibits Epithelial Na+TransportIn VitroandIn Vivo

(2009) Ahmed Lazrak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)

(2009) Scott D. Kuduk et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior

(2009) Adam E. Ziemann et al.   CELL

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1

(2009) Carole Planès et al.   EMBO Molecular Medicine

Rapid Rise of Extracellular pH Evoked by Neural Activity Is Generated by the Plasma Membrane Calcium ATPase

(2009) Sachin Makani et al.   JOURNAL OF NEUROPHYSIOLOGY

Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior

(2009) M. W. Coryell et al.   JOURNAL OF NEUROSCIENCE

Thiazolidinedione-Induced Fluid Retention Is Independent of Collecting Duct  ENaC Activity

(2009) V. Vallon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

(2009) Eric B. Gonzales et al.   NATURE

The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation

(2009) Yongjun Lu et al.   NEURON

SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage

(2009) A. Garcia-Caballero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventive but Not Late Amiloride Therapy Reduces Morbidity and Mortality of Lung Disease in βENaC-overexpressing Mice

(2008) Zhe Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ASIC3, a sensor of acidic and primary inflammatory pain

(2008) Emmanuel Deval et al.   EMBO JOURNAL

Regulation of ASIC activity by ASIC4 - new insights into ASIC channel function revealed by a yeast two-hybrid assay

(2008) Emmanuelle Donier et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sensing Tension

(2008) Heather A. Drummond et al.   HYPERTENSION

Plasmin Activates Epithelial Na+Channels by Cleaving the γ Subunit

(2008) Christopher J. Passero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits inXenopusOocytes

(2008) Michael Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation

(2008) Marcelo D. Carattino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ENaC Proteolytic Regulation by Channel-activating Protease 2

(2008) Agustín García-Caballero et al.   JOURNAL OF GENERAL PHYSIOLOGY

Dorsal Root Ganglion Neurons Innervating Skeletal Muscle Respond to Physiological Combinations of Protons, ATP, and Lactate Mediated by ASIC, P2X, and TRPV1

(2008) Alan R. Light et al.   JOURNAL OF NEUROPHYSIOLOGY

Pharmacological Properties of N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine Methanesulfonate (552-02), a Novel Epithelial Sodium Channel Blocker with Potential Clinical Efficacy for Cystic Fibrosis Lung Disease

(2008) A. J. Hirsh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel

(2008) P. Svenningsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

(2008) Motoko Chiga et al.   KIDNEY INTERNATIONAL

Acid-sensing ion channels interact with and inhibit BK K+ channels

(2008) E. Y. Petroff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low expression of the β-ENaC subunit impairs lung fluid clearance in the mouse

(2007) Nadia Randrianarison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome

(2007) Marko Bertog et al.   JOURNAL OF PHYSIOLOGY-LONDON