Journal
FEBS LETTERS
Volume 587, Issue 13, Pages 1929-1941Publisher
WILEY
DOI: 10.1016/j.febslet.2013.05.013
Keywords
Hypertension; Aldosterone; Angiotensin; Diuretics; Transgenic mouse model
Funding
- FNRS Grant
- Leducq foundation Transatlantic Network on Hypertension
- National Center of Competence in Research (NCCR
- Kidney CH)
Ask authors/readers for more resources
In this review, we discuss genetic evidence supporting Guyton's hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transport in the distal nephron and the collecting duct that are the most important sites for the control of sodium and potassium balance by aldosterone and angiotensin II. Thanks to the study of Mendelian forms of hypertension and their corresponding transgenic mouse models, three main classes of diuretic receptors (furosemide, thiazide, amiloride) and the main components of the aldosterone- and angiotensin-dependent signaling pathways were molecularly identified over the past 20 years. This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available