Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery

CX3CR1-CCR2-dependent monocyte-microglial signaling modulates neurovascular leakage and acute injury in a mouse model of childhood stroke

(2019) Joel Faustino et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia: Brain cells on the move

(2019) Sophie Marie-Thérèse Smolders et al.   PROGRESS IN NEUROBIOLOGY

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

(2019) Qingxiu Zhang et al.   PLOS BIOLOGY

Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer’s Disease

(2019) Franco-Bocanegra et al.   Cells

Update of inflammasome activation in microglia/macrophage in aging and aging‐related disease

(2019) Meng‐yan Hu et al.   CNS Neuroscience & Therapeutics

Microglia/macrophage diversities in central nervous system physiology and pathology

(2019) Di Xie et al.   CNS Neuroscience & Therapeutics

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice

(2018) Yaning Li et al.   Stem Cell Research & Therapy

Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

(2018) Kimberley D. Bruce et al.   Frontiers in Molecular Neuroscience

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke

(2018) Murielle G Kluge et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

(2018) Ligen Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Microglia enhanced the angiogenesis, migration and proliferation of co-cultured RMECs

(2018) Xinyi Ding et al.   BMC Ophthalmology

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke

(2018) Kota Kurisu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke

(2017) Hongxia Cai et al.   MOLECULAR THERAPY

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

(2017) Cláudia Caldeira et al.   Frontiers in Aging Neuroscience

Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative Diseases

(2017) Björn Spittau   Frontiers in Aging Neuroscience

Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice

(2016) Yuanyuan Ma et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Microglia Priming with Aging and Stress

(2016) Anzela Niraula et al.   NEUROPSYCHOPHARMACOLOGY

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia contact induces synapse formation in developing somatosensory cortex

(2016) Akiko Miyamoto et al.   Nature Communications

GOplot: an R package for visually combining expression data with functional analysis: Fig. 1.

(2015) Wencke Walter et al.   BIOINFORMATICS

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

(2015) Alicia A. Babcock et al.   BRAIN BEHAVIOR AND IMMUNITY

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

(2015) Jun Suenaga et al.   EXPERIMENTAL NEUROLOGY

Microglia in action: how aging and injury can change the brain’s guardians

(2015) Athanasios Lourbopoulos et al.   Frontiers in Cellular Neuroscience

Characteristics of spinal microglia in aged and obese mice: potential contributions to impaired sensory behavior

(2015) SeungHwan Lee et al.   Immunity & Ageing

The RhoA Guanine Nucleotide Exchange Factor, LARG, Mediates ICAM-1-Dependent Mechanotransduction in Endothelial Cells To Stimulate Transendothelial Migration

(2014) E. C. Lessey-Morillon et al.   JOURNAL OF IMMUNOLOGY

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

(2014) Xiaoming Hu et al.   PROGRESS IN NEUROBIOLOGY

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

(2014) Florian Kahles et al.   Molecular Metabolism

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration

(2013) Ravisekhar Gadepalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPβ and TNF-α

(2013) Yi-Hsia Liu et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity

(2012) Hyejin Jeon et al.   Journal of Neuroinflammation

The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells

(2012) Hyun-Jung Park et al.   MOLECULAR BIOLOGY OF THE CELL

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures

(2011) Simin F. Rymo et al.   PLoS One

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

The Temporal Dynamics of Poststroke Neuroinflammation: A Longitudinal Diffusion Tensor Imaging-Guided PET Study with 11C-PK11195 in Acute Subcortical Stroke

(2010) A. Thiel et al.   JOURNAL OF NUCLEAR MEDICINE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells

(2009) J Dai et al.   ONCOGENE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Insulin Growth Factor-1 Gene Transfer Enhances Neurovascular Remodeling and Improves Long-Term Stroke Outcome in Mice

(2008) Wei Zhu et al.   STROKE