Wnt/β‐catenin‐mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress

mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation

(2019) Jia‐Yi Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway

(2019) Xiang-Guang Li et al.   TOXICOLOGY LETTERS

Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice

(2019) Jia-yi Zhou et al.   FOOD AND CHEMICAL TOXICOLOGY

Extracellular Glutamate-Induced mTORC1 Activation via the IR/IRS/PI3K/Akt Pathway Enhances the Expansion of Porcine Intestinal Stem Cells

(2019) Min Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methionine and Its Hydroxyl Analogues Improve Stem Cell Activity To Eliminate Deoxynivalenol-Induced Intestinal Injury by Reactivating Wnt/β-Catenin Signaling

(2019) Jia-yi Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

LGR5 and BMI1 Increase Pig Intestinal Epithelial Cell Proliferation by Stimulating WNT/β-Catenin Signaling

(2018) Xiang-Guang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative and endoplasmic reticulum stress defense mechanisms of bovine granulosa cells exposed to heat stress

(2018) Teshome Wondie Alemu et al.   THERIOGENOLOGY

Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation

(2018) Winnie Y. Zou et al.   Cell Reports

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

α-Lipoic acid prevents the intestinal epithelial monolayer damage under heat stress conditions: model experiments in Caco-2 cells

(2017) Soheil Varasteh et al.   EUROPEAN JOURNAL OF NUTRITION

CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/β-Catenin Signaling Pathways

(2017) Hong-Bo Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis

(2017) Dana Elshaer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dexmedetomidine Protects Against Multi-Organ Dysfunction Induced by Heatstroke via Sustaining The Intestinal Integrity

(2017) Zhen-Na Xia et al.   SHOCK

Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model

(2017) Tingting Chen et al.   Food & Function

A novel culture system for adult porcine intestinal crypts

(2016) Hassan A. Khalil et al.   CELL AND TISSUE RESEARCH

Heat stress promotes the down-regulation of IRE1α in cells: An atypical modulation of the UPR pathway

(2016) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

Hsp70 expression induced by Co-Enzyme Q10 protected chicken myocardial cells from damage and apoptosis under in vitro heat stress

(2016) J. Xu et al.   POULTRY SCIENCE

Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival

(2016) Natik Piri et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury

(2016) Subhrajit Saha et al.   Nature Communications

Protective Effects of Ferulic Acid against Heat Stress-Induced Intestinal Epithelial Barrier Dysfunction In Vitro and In Vivo

(2016) Shasha He et al.   PLoS One

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage

(2015) S. Tao et al.   EMBO JOURNAL

Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells

(2015) Chun-qi Gao et al.   Journal of Zhejiang University-SCIENCE B

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD

(2015) J Cosín-Roger et al.   Mucosal Immunology

Effect of a probiotic mixture on intestinal microflora, morphology, and barrier integrity of broilers subjected to heat stress

(2014) J. Song et al.   POULTRY SCIENCE

Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration

(2013) Ciara Metcalfe et al.   Cell Stem Cell

Molecular cloning, sequence analysis, and function of the intestinal epithelial stem cell marker Bmi1 in pig intestinal epithelial cells1

(2013) C.-M. Li et al.   JOURNAL OF ANIMAL SCIENCE

IPEC-J2 Cells as Reporter System of the Anti-Inflammatory Control Actions of Interferon-Alpha

(2013) Elisabetta Razzuoli et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

E-cadherin is required for intestinal morphogenesis in the mouse

(2012) Benjamin J. Bondow et al.   DEVELOPMENTAL BIOLOGY

Secalonic Acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway

(2011) Jian-ye Zhang et al.   CELL CYCLE

Optimizing culture conditions of a porcine epithelial cell line IPEC-J2 through a histological and physiological characterization

(2011) Marisa M. Geens et al.   CYTOTECHNOLOGY

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88

(2010) S. E. Cheesman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV Protease Inhibitors Induce Endoplasmic Reticulum Stress and Disrupt Barrier Integrity in Intestinal Epithelial Cells

(2009) Xudong Wu et al.   GASTROENTEROLOGY

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

 -Catenin Promotes Survival of Renal Epithelial Cells by Inhibiting Bax

(2009) Z. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ

(2008) George Iliakis et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress

(2008) M. Verras et al.   MOLECULAR AND CELLULAR BIOLOGY

A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice

(2008) Catriona Paul et al.   REPRODUCTION

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE