Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases

Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy

(2018) Xiaolei Li et al.   Cellular & Molecular Immunology

Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients

(2018) Carol D. SanMartín et al.   Current Alzheimer Research

Alzheimer’s Disease, Oligomers, and Inflammation

(2018) Gianluigi Forloni et al.   JOURNAL OF ALZHEIMERS DISEASE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

(2018) Peer Aramillo Irizar et al.   Nature Communications

Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

(2018) Victoria Navarro et al.   Frontiers in Aging Neuroscience

Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease

(2018) Felipe Salech et al.   Frontiers in Neuroscience

Imbalance of Circulating Th17 and Regulatory T Cells in Alzheimer’s Disease: A Case Control Study

(2018) Timo Jan Oberstein et al.   Frontiers in Immunology

PD-1 deficiency is not sufficient to induce myeloid mobilization to the brain or alter the inflammatory profile during chronic neurodegeneration

(2018) J. Obst et al.   BRAIN BEHAVIOR AND IMMUNITY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Alzheimer's Disease is Associated with Decreased Risk of Cancer-Specific Mortality: A Prospective Study (NEDICES)

(2018) Juan Pablo Romero et al.   JOURNAL OF ALZHEIMERS DISEASE

Socioeconomic Differences in the Epidemiologic Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States, 2003 to 2015

(2018) Katherine G. Hastings et al.   ANNALS OF INTERNAL MEDICINE

Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models

(2017) Martine Latta-Mahieu et al.   GLIA

Let’s make microglia great again in neurodegenerative disorders

(2017) Marie-Victoire Guillot-Sestier et al.   JOURNAL OF NEURAL TRANSMISSION

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Differences of immune disorders between Alzheimer’s disease and breast cancer based on transcriptional regulation

(2017) Wei Kong et al.   PLoS One

Can immunotherapy treat neurodegeneration?

(2017) Michal Schwartz   SCIENCE

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

(2017) Felipe Salech et al.   Frontiers in Aging Neuroscience

Differential Phenotypes of Myeloid-Derived Suppressor and T Regulatory Cells and Cytokine Levels in Amnestic Mild Cognitive Impairment Subjects Compared to Mild Alzheimer Diseased Patients

(2017) Aurélie Le Page et al.   Frontiers in Immunology

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer’s Disease, Glioblastoma and Lung cancer

(2017) Jon Sánchez-Valle et al.   Scientific Reports

Regulatory T cells delay disease progression in Alzheimer-like pathology

(2016) Cira Dansokho et al.   BRAIN

The Basis of Oncoimmunology

(2016) A. Karolina Palucka et al.   CELL

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Neuroprotective effects of CD4+CD25+Foxp3+ regulatory T cells in a 3xTg-AD Alzheimer’s disease model

(2016) Hyunjung Baek et al.   Oncotarget

Recent global trends in the prevalence and incidence of dementia, and survival with dementia

(2016) Martin Prince et al.   Alzheimers Research & Therapy

Editorial: Direct and Inverse Comorbidities Between Complex Disorders

(2016) Rafael Tabarés-Seisdedos et al.   Frontiers in Physiology

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer

(2015) Benjamin Goeppert et al.   BRITISH JOURNAL OF CANCER

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Prognostic role of tumour-infiltrating inflammatory cells in brain tumours

(2015) Michał Bieńkowski et al.   CURRENT OPINION IN NEUROLOGY

Long term survival with cytotoxic T lymphocyte-associated antigen 4 blockade using tremelimumab

(2015) Zeynep Eroglu et al.   EUROPEAN JOURNAL OF CANCER

Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma

(2015) Dirk Schadendorf et al.   JOURNAL OF CLINICAL ONCOLOGY

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence

(2014) Jane A. Driver   BIOGERONTOLOGY

Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity

(2014) DP Ponce et al.   Current Alzheimer Research

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies

(2014) Ferrán Catalá-López et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Association of cancer history with Alzheimer's disease onset and structural brain changes

(2014) Kelly N. H. Nudelman et al.   Frontiers in Physiology

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Subtypes of cytotoxic lymphocytes and natural killer cells infiltrating cancer nests correlate with prognosis in patients with vulvar squamous cell carcinoma

(2013) Jacek Jan Sznurkowski et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study

(2013) M. Musicco et al.   NEUROLOGY

Nonmelanoma skin cancer is associated with reduced Alzheimer disease risk

(2013) R. S. White et al.   NEUROLOGY

Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice

(2013) Hongna Yang et al.   PLoS One

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Role of Foxp3-positive Tumor-infiltrating Lymphocytes in the Histologic Features and Clinical Outcomes of Hepatocellular Carcinoma

(2012) Alka Mary Mathai et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer's Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer's and Reduced Necrosis in Cancer

(2012) M. I. Behrens et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Does Alzheimer’s Disease Protect against Cancers? A Nationwide Population-Based Study

(2012) Shuo-Ming Ou et al.   NEUROEPIDEMIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treg Cells in Cancer: A Case of Multiple Personality Disorder

(2012) P. D. Bos et al.   Science Translational Medicine

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

(2011) Sahar M.A. Mahmoud et al.   JOURNAL OF CLINICAL ONCOLOGY

Age-Dependent Increases in Apoptosis/Necrosis Ratios in Human Lymphocytes Exposed to Oxidative Stress

(2011) Maria I. Behrens et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Low Cancer Rates among Patients with Dementia in a Population-Based Register Study in Sweden

(2010) Bo Attner et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer

(2010) Zhengbin Shen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Systemic inflammatory cells fight off neurodegenerative disease

(2010) Michal Schwartz et al.   Nature Reviews Neurology

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Common Biological Mechanism in Cancer and Alzheimers Disease?

(2009) M. Behrens et al.   Current Alzheimer Research

Cancer linked to Alzheimer disease but not vascular dementia

(2009) C. M. Roe et al.   NEUROLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE