Secondhand Smoke Induces Liver Steatosis through Deregulation of Genes Involved in Hepatic Lipid Metabolism

Smoking results in accumulation of ectopic fat in the liver

(2019) Ayako Kato et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease

(2019) Stella Tommasi et al.   International Journal of Environmental Research and Public Health

Cigarette smoking is a risk factor for the onset of fatty liver disease in nondrinkers: A longitudinal cohort study

(2018) Masashi Okamoto et al.   PLoS One

A comprehensive bioinformatics analysis on multiple Gene Expression Omnibus datasets of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Shanzhou Huang et al.   Scientific Reports

Role of xenobiotics in the induction and progression of fatty liver disease

(2018) James E. Klaunig et al.   Toxicology Research

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

(2017) Jose M. Irimia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Secondhand smoke induces hepatic apoptosis and fibrosis in hamster fetus

(2016) Chien-Wei Huang et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma

(2016) Heinz Zoller et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Liver — guardian, modifier and target of sepsis

(2016) Pavel Strnad et al.   Nature Reviews Gastroenterology & Hepatology

The Role of Lipin-1 in the Pathogenesis of Alcoholic Fatty Liver

(2015) Lijuan Bi et al.   ALCOHOL AND ALCOHOLISM

Molecular damage and lung tumors in cigarette smoke-exposed mice

(2015) Alberto Izzotti et al.   Annals of the New York Academy of Sciences

Hepatic lipid droplet biology: Getting to the root of fatty liver

(2015) Douglas G. Mashek et al.   HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke

(2015) Stella Tommasi et al.   LUNG CANCER

Epigenetic targeting of the Nanog pathway and signaling networks during chemical carcinogenesis

(2014) Stella Tommasi et al.   CARCINOGENESIS

Secondhand tobacco exposure is associated with nonalcoholic fatty liver disease in children

(2014) Connie Lin et al.   ENVIRONMENTAL RESEARCH

Exposure of mice to secondhand smoke elicits both transient and long-lasting transcriptional changes in cancer-related functional networks

(2014) Stella Tommasi et al.   INTERNATIONAL JOURNAL OF CANCER

Cohort Study of Non-alcoholic Fatty Liver Disease, NAFLD fibrosis score and the Risk of Incident Diabetes in a Korean population

(2013) Yoosoo Chang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Metabolic Regulation by p53 Family Members

(2013) Celia R. Berkers et al.   Cell Metabolism

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Active Smoking, Passive Smoking, and Risk of Nonalcoholic Fatty Liver Disease (NAFLD): A Population-Based Study in China

(2013) Yu Liu et al.   JOURNAL OF EPIDEMIOLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

(2013) Annika Mehlem et al.   Nature Protocols

Systematic functional regulatory assessment of disease-associated variants

(2013) Konrad J. Karczewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactive effects of smoking and glutathione S-transferase polymorphisms on the development of non-alcoholic fatty liver disease

(2013) Kentaro Oniki et al.   TOXICOLOGY LETTERS

Oxidative Stress and Chromatin Remodeling in Chronic Obstructive Pulmonary Disease and Smoking-Related Diseases

(2012) Isaac K. Sundar et al.   ANTIOXIDANTS & REDOX SIGNALING

Whole DNA methylome profiling in mice exposed to secondhand smoke

(2012) Stella Tommasi et al.   Epigenetics

New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers

(2012) Sang-In Kim et al.   FASEB JOURNAL

Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization

(2012) Stella Tommasi et al.   NUCLEIC ACIDS RESEARCH

Second-hand tobacco smoke and children

(2012) Eman M Al-Sayed et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Regulation of lipid metabolism by p53 – fighting two villains with one sword

(2012) Ido Goldstein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner

(2011) Victor Pashkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period

(2011) Ayaka Hamabe et al.   JOURNAL OF GASTROENTEROLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung

(2011) Sang-In Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing

(2010) Ahmad Besaratinia et al.   FASEB JOURNAL

Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity

(2010) Damir Zadravec et al.   FASEB JOURNAL

Clearing the smoke in chronic liver diseases

(2010) Claudia O. Zein   HEPATOLOGY

Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease

(2010) Claudia O. Zein et al.   JOURNAL OF HEPATOLOGY

Pediatric nonalcoholic fatty liver disease: Overview with emphasis on histology

(2010) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats

(2009) Lorenzo Azzalini et al.   HEPATOLOGY

Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1

(2009) Hongwei Yuan et al.   JOURNAL OF HEPATOLOGY

Cigarette smoke exposure: A novel cofactor of NAFLD progression?

(2009) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif

(2009) Y.-K. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice

(2008) Minhua Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Second-hand smoke and human lung cancer

(2008) Ahmad Besaratinia et al.   LANCET ONCOLOGY