Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism

A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential

(2019) C. Michael White   JOURNAL OF CLINICAL PHARMACOLOGY

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

(2019) Lilach O. Lerman et al.   HYPERTENSION

Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats

(2019) Rafał Kossakowski et al.   Frontiers in Pharmacology

A systematic review of cannabidiol dosing in clinical populations

(2019) S.A. Millar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy

(2019) Valentina Franco et al.   DRUGS

Interplay of liver‐heart inflammatory axis and cannabinoid 2 receptor signalling in an experimental model of hepatic cardiomyopathy

(2019) Csaba Matyas et al.   HEPATOLOGY

Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice

(2019) Georg D. Duerr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

(2019) Brigitta Kis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertension

(2019) Greg A. Knock   FREE RADICAL BIOLOGY AND MEDICINE

Gender-specific association between the blood pressure category according to the updated ACC/AHA guidelines for hypertension and cardio-ankle vascular index: a community-based cohort study

(2019) Tatsuya Kamon et al.   Journal of Cardiology

Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries

(2019) Marta Baranowska-Kuczko et al.   JOURNAL OF HYPERTENSION

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

(2019) Sinemyiz Atalay et al.   Antioxidants

Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats

(2018) Jennifer A. Shearer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation

(2018) Janos Paloczi et al.   ANTIOXIDANTS & REDOX SIGNALING

Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance

(2018) Barbara Malinowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhanced endocannabinoid tone as a potential target of pharmacotherapy

(2018) Marek Toczek et al.   LIFE SCIENCES

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice

(2018) Julian Jehle et al.   PLoS One

Study of sample preparation for determination of endocannabinoids and analogous compounds in human serum by LC–MS/MS in MRM mode

(2018) D. Luque-Córdoba et al.   TALANTA

The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension

(2018) Michał Biernacki et al.   MOLECULES

Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma

(2018) Michał Biernacki et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

JNK regulates muscle remodeling via myostatin/SMAD inhibition

(2018) Sarah J. Lessard et al.   Nature Communications

Targeting fatty acid amide hydrolase as a therapeutic strategy for antitussive therapy

(2017) Michael A. Wortley et al.   EUROPEAN RESPIRATORY JOURNAL

2-Arachidonoylglycerol ameliorates inflammatory stress-induced insulin resistance in cardiomyocytes

(2017) Dipanjan Chanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Chronic Activation of the Novel Endocannabinoid Receptor GPR18 on Myocardial Function and Blood Pressure in Conscious Rats

(2017) Asmaa I. Matouk et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Activation of Endocannabinoid Receptor 2 as a Mechanism of Propofol Pretreatment-Induced Cardioprotection against Ischemia-Reperfusion Injury in Rats

(2017) Hai-Jing Sun et al.   Oxidative Medicine and Cellular Longevity

Cannabidiol: State of the art and new challenges for therapeutic applications

(2017) Simona Pisanti et al.   PHARMACOLOGY & THERAPEUTICS

In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats

(2017) Amanda J. Wheal et al.   Frontiers in Pharmacology

A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol

(2017) Salahaden R. Sultan et al.   Frontiers in Pharmacology

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

(2017) Shanshan Sun et al.   Redox Biology

Cannabidiol attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury

(2017) Yuping Wang et al.   Scientific Reports

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation

(2016) Wen-Shin Lee et al.   MOLECULAR MEDICINE

Perspectives and challenges of antioxidant therapy for atrial fibrillation

(2016) Iveta Gasparova et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Modulation of cellular redox homeostasis by the endocannabinoid system

(2016) Christopher Lipina et al.   Open Biology

Role of the endocannabinoid system in diabetes and diabetic complications

(2015) G Gruden et al.   BRITISH JOURNAL OF PHARMACOLOGY

Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

(2015) John M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Unknown

(2015) Enkui Hao et al.   MOLECULAR MEDICINE

G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction

(2015) Gayathri Rajaraman et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy

(2014) Lili Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs

(2014) Antoni Pastor et al.   JOURNAL OF LIPID RESEARCH

Laboratory Markers of Ventricular Arrhythmia Risk in Renal Failure

(2014) Ioana Mozos   Biomed Research International

Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity

(2013) Amr A. Fouad et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress

(2013) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

Is the cardiovascular system a therapeutic target for cannabidiol?

(2012) Christopher P. Stanley et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?

(2011) Barbara Malinowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

(2011) George W. Booz   FREE RADICAL BIOLOGY AND MEDICINE

Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress

(2011) Érica M. Granjeiro et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Assessment of a Spectrophotometric Assay for Monoacylglycerol Lipase Activity

(2010) Nadine M. Ulloa et al.   AAPS Journal

Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture

(2010) Omar J. Cassol-Jr et al.   BRAIN RESEARCH

Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells

(2010) Mohanraj Rajesh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes

(2010) Luciano De Petrocellis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury

(2010) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

(2010) Mohanraj Rajesh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

5-HT1Areceptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

(2009) Leonardo B.M. Resstel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

(2009) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of anandamide transporter in regulating calcitonin gene-related peptide production and blood pressure in hypertension

(2009) Dai Li et al.   JOURNAL OF HYPERTENSION

CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion

(2009) Fabrizio Montecucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma

(2008) Patricia M.W. Lam et al.   ANALYTICAL BIOCHEMISTRY

‘Entourage’ effects ofN-palmitoylethanolamide andN-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors

(2008) W-SV Ho et al.   BRITISH JOURNAL OF PHARMACOLOGY