Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Drebrin regulates angiotensin II-induced aortic remodelling

(2018) Lisheng Zhang et al.   CARDIOVASCULAR RESEARCH

Protein Kinase D was involved in vascular remodeling in spontaneously hypertensive rats

(2018) Jing Geng et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative StressNovelty and Significance

(2018) María S. Avendaño et al.   HYPERTENSION

Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model

(2018) Ahmad F. Hedayat et al.   Translational Research

Short-Term Angiotensin II Treatment Affects Large Artery Biomechanics and Function in the Absence of Small Artery Alterations in Mice

(2018) Arthur J. A. Leloup et al.   Frontiers in Physiology

Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology

(2017) Leticia Aragao-Santiago et al.   ENDOCRINOLOGY

Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent HypertensionNovelty and Significance

(2017) Kohei Ueda et al.   HYPERTENSION

Hypertensive Kidney Injury and the Progression of Chronic Kidney Disease

(2017) Karen A. Griffin   HYPERTENSION

Bridging the Gap between Reproducibility and Translation: Data Resources and Approaches

(2017) Caroline J. Zeiss et al.   ILAR JOURNAL

Genomic Tools for the Use of Nonhuman Primates in Translational Research

(2017) John D. Harding   ILAR JOURNAL

Antihypertensive Drugs Aliskiren, Nebivolol, and Olmesartan Reduce Hypertension by Reducing Endothelial Microparticles and Regulating Angiogenesis

(2017) Moon Jain et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Two-kidney one-clip is a pertinent approach to integrate arterial hypertension in animal models of stroke: Serial magnetic resonance imaging studies of brain lesions before and during cerebral ischemia

(2017) Benjamin Ménard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis

(2017) Luciana C. Veiras et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: The aldosterone-mineralocorticoid receptor-Nox1 axis

(2017) Adam P. Harvey et al.   LIFE SCIENCES

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat

(2017) Peter A. Doris   PHYSIOLOGICAL GENOMICS

Circular RNAs in rat models of cardiovascular and renal diseases

(2017) Xi Cheng et al.   PHYSIOLOGICAL GENOMICS

Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans

(2017) Sandosh Padmanabhan et al.   PHYSIOLOGICAL REVIEWS

Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat

(2017) Man Chun John Ma et al.   PLoS One

Generation and phenotypic characterization of Pde1a mutant mice

(2017) Xiaofang Wang et al.   PLoS One

Precise spatio-temporal control of rapid optogenetic cell ablation with mem-KillerRed in Zebrafish

(2017) C. Buckley et al.   Scientific Reports

Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA

(2017) Xi Cheng et al.   PLoS Genetics

Tail‐Cuff Technique and Its Influence on Central Blood Pressure in the Mouse

(2017) Elena Wilde et al.   Journal of the American Heart Association

Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice

(2017) Huiying Gu et al.   Scientific Reports

Role of COX-2-derived PGE2on vascular stiffness and function in hypertension

(2016) M S Avendaño et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron

(2016) Jiandong Zhang et al.   Cell Metabolism

Differential contribution of endothelium-derived relaxing factors to vascular reactivity in conduit and resistance arteries from normotensive and hypertensive rats

(2016) Jiaye Jiang et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Transient Receptor Potential Melastatin 7 Cation Channel KinaseNovelty and Significance

(2016) Tayze T. Antunes et al.   HYPERTENSION

Salt Sensitivity of Blood Pressure

(2016) Fernando Elijovich et al.   HYPERTENSION

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models

(2016) Saiful A. Mir et al.   JOURNAL OF HYPERTENSION

Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

(2016) Anja Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of MMP-9 attenuates hypertensive cerebrovascular dysfunction in Dahl salt-sensitive rats

(2016) Anuradha Kalani et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Animal models of metabolic syndrome: a review

(2016) Sok Kuan Wong et al.   Nutrition & Metabolism

Histopathological characteristics of renal changes in humanrenin-angiotensinogen double transgenic rats

(2016) Tomoaki Tochitani et al.   Journal of Toxicologic Pathology

ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes

(2016) Kazuto Yoshimi et al.   Nature Communications

Carotid Artery Vascular Mechanics Serve as Biomarkers of Cognitive Dysfunction in Aortic‐Banded Miniature Swine That Can Be Treated With an Exercise Intervention

(2016) T. Dylan Olver et al.   Journal of the American Heart Association

The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research

(2016) Marc T. Avey et al.   PLoS One

The Researchers’ View of Scientific Rigor—Survey on the Conduct and Reporting of In Vivo Research

(2016) Thomas S. Reichlin et al.   PLoS One

Identification and characterization of rabbit ROSA26 for gene knock-in and stable reporter gene expression

(2016) Dongshan Yang et al.   Scientific Reports

The Role of the (Pro)renin Receptor in Hypertensive Disease

(2015) A.H. Jan Danser   AMERICAN JOURNAL OF HYPERTENSION

A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation

(2015) Dan Li et al.   AMERICAN JOURNAL OF HYPERTENSION

Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor

(2015) Paulo W. Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat

(2015) Fan Fan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system

(2015) S. Sugin Lal Jabaris et al.   BRAIN RESEARCH

Involvement of peroxisome proliferator-activated receptors in cardiac and vascular remodeling in a novel minipig model of insulin resistance and atherosclerosis induced by consumption of a high-fat/cholesterol diet

(2015) Pan Yongming et al.   Cardiovascular Diabetology

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Gut microbiota in hypertension

(2015) Pedro A. Jose et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Mechanisms and therapeutic potential of microRNAs in hypertension

(2015) Lijun Shi et al.   DRUG DISCOVERY TODAY

Mineralocorticoid Excess or Glucocorticoid InsufficiencyNovelty and Significance

(2015) Linda J. Mullins et al.   HYPERTENSION

Cardiac Metabolic Alterations in Hypertensive Obese PigsNovelty and Significance

(2015) Xin Zhang et al.   HYPERTENSION

Dr Lewis Kitchener Dahl, the Dahl Rats, and the "Inconvenient Truth" About the Genetics of Hypertension

(2015) B. Joe   HYPERTENSION

Molecular-Based Mechanisms of Mendelian Forms of Salt-Dependent Hypertension: Questioning the Prevailing Theory

(2015) T. W. Kurtz et al.   HYPERTENSION

Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats

(2015) Allen W. Cowley et al.   HYPERTENSION

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Increased Cerebrovascular Sensitivity to Endothelin-1 in a Rat Model of Obstructive Sleep Apnea: A Role for Endothelin Receptor B

(2015) David J Durgan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion

(2015) M. A. Sparks et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

(2015) Benjamin P Kleinstiver et al.   NATURE BIOTECHNOLOGY

Evidence for a link between gut microbiota and hypertension in the Dahl rat

(2015) Blair Mell et al.   PHYSIOLOGICAL GENOMICS

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Obesity-metabolic derangement exacerbates cardiomyocyte loss distal to moderate coronary artery stenosis in pigs without affecting global cardiac function

(2014) Zi-Lun Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Postmenopausal hypertension: role of the sympathetic nervous system in an animal model

(2014) Rodrigo O. Maranon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Female sex hormones protect against salt-sensitive hypertension but not essential hypertension

(2014) Krystal N. Brinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cardiovascular Risks Associated With Diastolic Blood Pressure and Isolated Diastolic Hypertension

(2014) Yan Li et al.   CURRENT HYPERTENSION REPORTS

Angiotensin II and Vascular Injury

(2014) Augusto C. Montezano et al.   CURRENT HYPERTENSION REPORTS

Female Spontaneously Hypertensive Rats Have a Compensatory Increase in Renal Regulatory T Cells in Response to Elevations in Blood Pressure

(2014) Ashlee J. Tipton et al.   HYPERTENSION

Critical Blood Pressure Threshold Dependence of Hypertensive Injury and Repair in a Malignant Nephrosclerosis Model

(2014) Karen A. Griffin et al.   HYPERTENSION

Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107

(2014) K. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Vein Levels of MicroRNA-26a Are Lower in the Poststenotic Kidney

(2014) X.-Y. Zhu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypertension Is a Major Contributor to 20-Hydroxyeicosatetraenoic Acid-Mediated Kidney Injury in Diabetic Nephropathy

(2014) M. H. Gangadhariah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelin-A Receptor Antagonism after Renal Angioplasty Enhances Renal Recovery in Renovascular Disease

(2014) A. R. Chade et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

A practical guide to subtotal nephrectomy in the rat with subsequent methodology for assessing renal and cardiac function

(2014) Yuan Zhang et al.   NEPHROLOGY

Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity

(2014) Aditya S. Pawar et al.   Obesity

Generation of TALEN-Mediated GRdim Knock-In Rats by Homologous Recombination

(2014) Verónica Ponce de León et al.   PLoS One

Dichotomous Effects of Chronic Intermittent Hypoxia on Focal Cerebral Ischemic Injury

(2014) Katherine A. Jackman et al.   STROKE

Efficient creation of an APOE knockout rabbit

(2014) Diana Ji et al.   TRANSGENIC RESEARCH

Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR–Cas platform

(2014) K. Yoshimi et al.   Nature Communications

A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries

(2013) Randy F. Crossland et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Usefulness of A Mouse Model of Reversible Pulmonary Arterial Hypertension: Be Cautious, Choose Carefully

(2013) José Gomez-Arroyo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

An inducible transgenic mouse model for familial hypertension with hyperkalaemia (Gordon's syndrome or pseudohypoaldosteronism type II)

(2013) Jabed A. Chowdhury et al.   CLINICAL SCIENCE

Novel ROSA26 Cre-reporter Knock-in C57BL/6N Mice Exhibiting Green Emission before and Red Emission after Cre-mediated Recombination

(2013) Yoshikazu Hasegawa et al.   EXPERIMENTAL ANIMALS

Identifying multiple causative genes at a single GWAS locus

(2013) M. J. Flister et al.   GENOME RESEARCH

Reversal of Genetic Salt-Sensitive Hypertension by Targeted Sympathetic Ablation

(2013) Jason D. Foss et al.   HYPERTENSION

Heterozygous Disruption of Renal Outer Medullary Potassium Channel in Rats Is Associated With Reduced Blood Pressure

(2013) Xiaoyan Zhou et al.   HYPERTENSION

Investing in High Blood Pressure Research

(2013) Zorina S. Galis et al.   HYPERTENSION

Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension

(2013) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension

(2013) Koji Hosaka et al.   Journal of NeuroInterventional Surgery

A zebrafish model of conditional targeted podocyte ablation and regeneration

(2013) Jianmin Huang et al.   KIDNEY INTERNATIONAL

Characteristics of Resistant Hypertension in a Large, Ethnically Diverse Hypertension Population of an Integrated Health System

(2013) John J. Sim et al.   MAYO CLINIC PROCEEDINGS

Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood–brain barrier breakdown after transient ischemia with long-term reperfusion

(2013) Xu Zhang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Roles of Hypertension in the Rupture of Intracranial Aneurysms

(2013) Yoshiteru Tada et al.   STROKE

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cautious use of fli1a:EGFP transgenic zebrafish in vascular research

(2012) Zhibin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Expression of NAD(P)H Oxidase Subunit p67phox in the Renal Medulla Contributes to Excess Oxidative Stress and Salt-Sensitive Hypertension

(2012) Di Feng et al.   Cell Metabolism

A Novel Role for Type 1 Angiotensin Receptors on T Lymphocytes to Limit Target Organ Damage in Hypertension

(2012) Jian-dong Zhang et al.   CIRCULATION RESEARCH

Translational study of microRNAs and its application in kidney disease and hypertension research

(2012) Alison J. Kriegel et al.   CLINICAL SCIENCE

Direct Angiotensin II Type 2 Receptor Stimulation in N ω -Nitro- l -Arginine-Methyl Ester–Induced Hypertension

(2012) Ludovit Paulis et al.   HYPERTENSION

Endothelin 1–Dependent Neurovascular Dysfunction in Chronic Intermittent Hypoxia

(2012) Carmen Capone et al.   HYPERTENSION

Hypertension Induces Brain β-Amyloid Accumulation, Cognitive Impairment, and Memory Deterioration Through Activation of Receptor for Advanced Glycation End Products in Brain Vasculature

(2012) Daniela Carnevale et al.   HYPERTENSION

The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?

(2012) Toru Nabika et al.   HYPERTENSION RESEARCH

Development of structural kidney damage in spontaneously hypertensive rats

(2012) Michael Hultström   JOURNAL OF HYPERTENSION

Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

(2012) C. Capone et al.   JOURNAL OF NEUROSCIENCE

Chronic Reduction of Nitric Oxide Level in Adult Spontaneously Hypertensive Rats Induces Aortic Stiffness Similar to Old Spontaneously Hypertensive Rats

(2012) Marc Isabelle et al.   JOURNAL OF VASCULAR RESEARCH

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Chronic perfusion of angiotensin II causes cognitive dysfunctions and anxiety in mice

(2012) S. Duchemin et al.   PHYSIOLOGY & BEHAVIOR

Myelin Loss Associated With Neuroinflammation in Hypertensive Rats

(2012) Fakhreya Y. Jalal et al.   STROKE

Sex differences in primary hypertension

(2012) Kathryn Sandberg et al.   Biology of Sex Differences

Reversal of Experimental Renovascular Hypertension Restores Coronary Microvascular Function and Architecture

(2011) V. H. Urbieta-Caceres et al.   AMERICAN JOURNAL OF HYPERTENSION

PVN adenovirus-siRNA injections silencing either NOX2 or NOX4 attenuate aldosterone/NaCl-induced hypertension in mice

(2011) Baojian Xue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure

(2011) Huiping Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AT 1A Angiotensin Receptors in the Renal Proximal Tubule Regulate Blood Pressure

(2011) Susan B. Gurley et al.   Cell Metabolism

No Effect of Short-Term Hypertension on Bone Matrix Mineralization in a Surgical Animal Model in Immature Rabbits

(2011) Jochen G. Hofstaetter et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Cardiovascular-Renal and Metabolic Characterization of a Rat Model of Polycystic Ovary Syndrome

(2011) Licy L. Yanes et al.   Gender Medicine

Artificial microRNA interference targeting AT1a receptors in paraventricular nucleus attenuates hypertension in rats

(2011) Z-D Fan et al.   GENE THERAPY

Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice

(2011) Justin L. Grobe et al.   HYPERTENSION

Creation and Characterization of a Renin Knockout Rat

(2011) Carol Moreno et al.   HYPERTENSION

Hsd11b2 Haploinsufficiency in Mice Causes Salt Sensitivity of Blood Pressure

(2011) Matthew A. Bailey et al.   HYPERTENSION

Vascular Remodeling in Hypertension

(2011) Ernesto L. Schiffrin   HYPERTENSION

Is the Spontaneously Hypertensive Stroke Prone Rat a Pertinent Model of Sub Cortical Ischemic Stroke? A Systematic Review

(2011) Emma L. Bailey et al.   International Journal of Stroke

A novel vascular clip design for the reliable induction of 2-kidney, 1-clip hypertension in the rat

(2011) Stephen P. Chelko et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cerebral Microvascular Inflammation in DOCA Salt-Induced Hypertension: Role of Angiotensin II and Mitochondrial Superoxide

(2011) Stephen F Rodrigues et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hyperglycemia and Renin-Dependent Hypertension Synergize to Model Diabetic Nephropathy

(2011) B. R. Conway et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

Motor and cognitive deficits in mice bred to have low or high blood pressure

(2011) Richard E. Hartman et al.   PHYSIOLOGY & BEHAVIOR

Promoter hypomethylation upregulates Na+–K+–2Cl− cotransporter 1 in spontaneously hypertensive rats

(2010) Hae-Ahm Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Renal Microvascular Disease Determines the Responses to Revascularization in Experimental Renovascular Disease

(2010) Alejandro R. Chade et al.   Circulation-Cardiovascular Interventions

Zinc-finger nucleases: new strategies to target the rat genome

(2010) Aron M. Geurts et al.   CLINICAL SCIENCE

Postmenopausal Hypertension

(2010) Licy L. Yanes et al.   HYPERTENSION

Renal Medullary MicroRNAs in Dahl Salt-Sensitive Rats

(2010) Yong Liu et al.   HYPERTENSION

Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model

(2010) Asada Leelahavanichkul et al.   KIDNEY INTERNATIONAL

Myocardial fibrosis in response to Angiotensin II is preceded by the recruitment of mesenchymal progenitor cells

(2010) Mryanda J Sopel et al.   LABORATORY INVESTIGATION

High-fat diet-induced obesity in animal models

(2010) Niloofar Hariri et al.   NUTRITION RESEARCH REVIEWS

Gene targeting in the rat: advances and opportunities

(2010) Howard J. Jacob et al.   TRENDS IN GENETICS

Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats

(2009) Jennifer C. Sullivan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Vascular remodeling, macro- and microvessels: Therapeutic implications

(2009) Damiano Rizzoni et al.   BLOOD PRESSURE

Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage

(2009) Heda Kvakan et al.   CIRCULATION

Effect of High Fat Loading in Dahl Salt-Sensitive Rats

(2009) Ai Nagae et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Elastase-Induced Intracranial Aneurysms in Hypertensive Mice

(2009) Yoshitsugu Nuki et al.   HYPERTENSION

Angiotensin-converting Enzyme Is a Modifier of Hypertensive End Organ Damage

(2009) Xiaojun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spontaneous Intracerebral Hemorrhage during Acute and Chronic Hypertension in Mice

(2009) Yoshinobu Wakisaka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recent Advances in Small-Animal Cardiovascular Imaging

(2009) B. M.W. Tsui et al.   JOURNAL OF NUCLEAR MEDICINE

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Metabolic Syndrome: Comparison of the Two Commonly Used Animal Models

(2008) M. Oron-Herman et al.   AMERICAN JOURNAL OF HYPERTENSION

Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension

(2008) Simonetta Friso et al.   ATHEROSCLEROSIS

Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

(2008) Ping Li et al.   CELL

Capture of Authentic Embryonic Stem Cells from Rat Blastocysts

(2008) Mia Buehr et al.   CELL

Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors

(2008) Florian Gembardt et al.   FASEB JOURNAL

Endogenous Melanocortin System Activity Contributes to the Elevated Arterial Pressure in Spontaneously Hypertensive Rats

(2008) Alexandre A. da Silva et al.   HYPERTENSION

Sex Differences in the Pressor Response to Angiotensin II When the Endogenous Renin-Angiotensin System Is Blocked

(2008) Julio C. Sartori-Valinotti et al.   HYPERTENSION

Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice

(2008) Shinji Inaba et al.   HYPERTENSION

Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach: The Millennium Genome Project for Hypertension

(2008) Katsuhiko KOHARA et al.   HYPERTENSION RESEARCH

Diabetic eNOS knockout mice develop distinct macro- and microvascular complications

(2008) Sumathy Mohan et al.   LABORATORY INVESTIGATION

Progress and prospects in rat genetics: a community view

(2008) Timothy J Aitman et al.   NATURE GENETICS

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

(2008) Weizhen Ji et al.   NATURE GENETICS

Aliskiren: the first renin inhibitor for clinical treatment

(2008) Chris Jensen et al.   NATURE REVIEWS DRUG DISCOVERY

Exaggeration of Focal Cerebral Ischemia in Transgenic Mice Carrying Human Renin and Human Angiotensinogen Genes

(2008) Shinji Inaba et al.   STROKE