G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction

An atlas of G-protein coupled receptor expression and function in human subcutaneous adipose tissue

(2015) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

GPR55: From orphan to metabolic regulator?

(2015) Bo Liu et al.   PHARMACOLOGY & THERAPEUTICS

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism

(2014) Linda Console-Bram et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature

(2014) Jessica MacIntyre et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment

(2014) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries

(2014) Marta Baranowska-Kuczko et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A GPR18-based signalling system regulates IOP in murine eye

(2013) Meggie D. Caldwell et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

A potential role for GPR55 in the regulation of energy homeostasis

(2013) Anna C. Simcocks et al.   DRUG DISCOVERY TODAY

Dietary Linoleic Acid Elevates the Endocannabinoids 2-AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet

(2013) Anita Røyneberg Alvheim et al.   LIPIDS

Chronic treatment with krill powder reduces plasma triglyceride and anandamide levels in mildly obese men

(2013) Kjetil Berge et al.   Lipids in Health and Disease

Relationship between serum levels of triglycerides and vascular inflammation, measured as COX-2, in arteries from diabetic patients: a translational study

(2013) Antonio Gordillo-Moscoso et al.   Lipids in Health and Disease

Dietary Influence on MAPK-Signaling Pathways and Risk of Colon and Rectal Cancer

(2013) Martha L. Slattery et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study

(2013) Joseph Abdulnour et al.   Obesity

Tools for GPCR drug discovery

(2012) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

N -arachidonoyl glycine induces macrophage apoptosis via GPR18

(2012) Rina Takenouchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New vistas for treatment of obesity and diabetes? Endocannabinoid signalling and metabolism in the modulation of energy balance

(2012) Christopher Lipina et al.   BIOESSAYS

GPR18 in microglia: implications for the CNS and endocannabinoid system signalling

(2012) D McHugh   BRITISH JOURNAL OF PHARMACOLOGY

Should we treat infection or inflammation to prevent T2DM?

(2012) Outi Vaarala et al.   Nature Reviews Endocrinology

So what do we call GPR18 now?

(2011) SPH Alexander   BRITISH JOURNAL OF PHARMACOLOGY

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells

(2011) Douglas McHugh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

The L- -Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity

(2011) J. M. Moreno-Navarrete et al.   DIABETES

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats

(2011) A. Díaz-Arteaga et al.   DIABETES OBESITY & METABOLISM

Obesity and susceptibility to autoimmune diseases

(2011) Claudio Procaccini et al.   Expert Review of Clinical Immunology

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans

(2011) Silvana Y Romero-Zerbo et al.   JOURNAL OF ENDOCRINOLOGY

Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise

(2011) Tongjian You et al.   Lipids in Health and Disease

Peripheral effects of the endocannabinoid system in energy homeostasis: Adipose tissue, liver and skeletal muscle

(2011) Cristoforo Silvestri et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

Ligand-directed signalling at β-adrenoceptors

(2010) Bronwyn A. Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels

(2010) Neelam Parmar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Involvement of adipokines in rimonabant-mediated insulin sensitivity inob/obmice

(2010) Jogeswar Mohapatra et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Quantification of Functional Selectivity at the Human  1A-Adrenoceptor

(2010) B. A. Evans et al.   MOLECULAR PHARMACOLOGY

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target

(2010) Y. Qin et al.   Pigment Cell & Melanoma Research

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding

(2009) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-Type Calcium Channel Inhibition Underlies the Analgesic Effects of the Endogenous Lipoamino Acids

(2009) G. Barbara et al.   JOURNAL OF NEUROSCIENCE

Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine

(2008) Andreas Artmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids

(2008) T. M. D'Eon et al.   DIABETES

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

(2008) M. Y. Donath et al.   DIABETES CARE

The endocannabinoid system in obesity and type 2 diabetes

(2008) V. Di Marzo   DIABETOLOGIA

Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

(2008) A. K. H. Lim et al.   DIABETOLOGIA

Identification of Farnesyl Pyrophosphate andN-Arachidonylglycine as Endogenous Ligands for GPR92

(2008) Da Young Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoids and Nutrition

(2008) H. S. Hansen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets

(2008) Isabel Matias et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Endocannabinoids, metabolic regulation, and the role of diet

(2008) Timothy P. Carr et al.   NUTRITION RESEARCH

The CB1 Endocannabinoid System Modulates Adipocyte Insulin Sensitivity

(2008) Roja Motaghedi et al.   Obesity

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet

(2008) Katarzyna M. Starowicz et al.   Obesity

Novel cannabinoid receptors

(2007) A J Brown   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta

(2007) E Herradón et al.   BRITISH JOURNAL OF PHARMACOLOGY

The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects

(2007) D G Johns et al.   BRITISH JOURNAL OF PHARMACOLOGY

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

(2007) Leeza A.Q. Vuong et al.   NEUROPHARMACOLOGY