RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology

RASGRP2 Suppresses Apoptosis via Inhibition of ROS Production in Vascular Endothelial Cells

(2019) Takuma Sato et al.   TheScientificWorldJOURNAL

Hereditary platelet function disorder from RASGRP2 gene mutations encoding CalDAG-GEFI identified by whole exome sequencing in a Korean woman with severe bleeding

(2019) Jae Won Yun et al.   HAEMATOLOGICA

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

(2019) Toma-Fukai et al.   MOLECULES

Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies

(2019) Barbara Lunghi et al.   HAEMATOLOGICA

Subcellular localization of Rap1 GTPase activator CalDAG‐GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides

(2019) Muzaddid Sarker et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel variants in FERMT3 and RASGRP2 —Genetic linkage in Glanzmann‐like bleeding disorders

(2019) Georgi Manukjan et al.   PEDIATRIC BLOOD & CANCER

The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells

(2019) Jun-ichi Takino et al.   Scientific Reports

Platelet Signaling Pathways and New Inhibitors

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Disrupted striatal neuron inputs and outputs in Huntington's disease

(2018) Anton Reiner et al.   CNS Neuroscience & Therapeutics

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI

(2018) Aaron A. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopic RASGRP2 (CalDAG-GEFI) expression in rheumatoid synovium contributes to the development of destructive arthritis

(2018) Hiroyuki Nakamura et al.   ANNALS OF THE RHEUMATIC DISEASES

The Many Faces of Rap1 GTPase

(2018) Anna Jaśkiewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

(2018) Jarny Choi et al.   NUCLEIC ACIDS RESEARCH

Peripartum bleeding management in a patient with CalDAG-GEFI deficiency

(2017) M. Canault et al.   HAEMOPHILIA

Negative regulators of platelet activation and adhesion

(2017) L. Stefanini et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis

(2017) Teresa Sevivas et al.   PLATELETS

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp)

(2017) Emilse Bermejo et al.   PLATELETS

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on HemostasisHighlights

(2016) Raymond Piatt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in MiceSignificance

(2016) Yacine Boulaftali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation

(2016) Jinqi Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction

(2016) M. L. Lozano et al.   BLOOD

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Human CalDAG-GEFI deficiency increases bleeding and delays  IIb 3 activation

(2016) H. Kato et al.   BLOOD

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

(2016) Florian Beck et al.   BLOOD

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

(2016) Taku Nagai et al.   NEURON

Inherited thrombopathia in Simmental cattle

(2016) M Aebi et al.   SCHWEIZER ARCHIV FUR TIERHEILKUNDE

New Insights Into the Treatment of Glanzmann Thrombasthenia

(2016) Man-Chiu Poon et al.   TRANSFUSION MEDICINE REVIEWS

NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes

(2016) Chongzhi Zang et al.   Scientific Reports

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

(2014) J. C. Riches et al.   BLOOD

Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics

(2014) L. M. Simon et al.   BLOOD

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca2+-dependent activation of platelet Rap1b GTPase

(2013) Gianni Francesco Guidetti et al.   BIOCHEMICAL JOURNAL

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation

(2013) H. Subramanian et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

(2012) J. M. Burkhart et al.   BLOOD

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

(2012) Sabine Suire et al.   EMBO JOURNAL

The Role of Ras Guanine Nucleotide Releasing Protein 4 in FcϵRI-mediated Signaling, Mast Cell Function, and T Cell Development

(2012) Minghua Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes

(2011) J. W. Rowley et al.   BLOOD

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling

(2011) Anika Stadtmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis

(2011) F. AHMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of the Gene Regulatory Region in Human rasgrp2 Gene in Vascular Endothelial Cells

(2010) Kentaro Nagamine et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease

(2010) Jill R. Crittenden et al.   HUMAN MOLECULAR GENETICS

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis

(2010) C. Carbo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis

(2009) Roberto J. Botelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

(2009) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XRASGRP2 expression during early development of Xenopus embryos

(2008) Kentaro Nagamine et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD