Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

(2012) José L. Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of transmembrane domain 3 of human melanocortin-4 receptor

(2012) Xiu-Lei Mo et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pleiotropic functions of the transmembrane domain 6 of human melanocortin-4 receptor

(2012) Hui Huang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?

(2012) Anne Rediger et al.   NEUROENDOCRINOLOGY

Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging

(2011) Rinshi S. Kasai et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Exploring a role for heteromerization in GPCR signalling specificity

(2010) Raphael Rozenfeld et al.   BIOCHEMICAL JOURNAL

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling

(2010) Andreas Breit et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GPCR Dimers Fall Apart

(2010) N. A. Lambert   Science Signaling

Receptor heteromerization and drug discovery

(2010) Raphael Rozenfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

(2009) Aishwarya Ravindran et al.   BIOCHEMISTRY

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy

(2009) R Krishna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models

(2009) Catherine L. Worth et al.   PLoS One

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor

(2008) Filippo Mancia et al.   EMBO REPORTS

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R

(2008) Patrick Tarnow et al.   Obesity Facts