Sphingolipids in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma: Ceramide Turnover

Serum sphingolipids predict de novo hepatocellular carcinoma in hepatitis C cirrhotic patients with sustained virologic response

(2019) Victoria T. Mücke et al.   LIVER INTERNATIONAL

Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights

(2018) Kristen Stephenson et al.   GENE EXPRESSION

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

(2018) Yasuo Takashima et al.   CANCER SCIENCE

The effect of high-fat diet and inhibition of ceramide production on insulin action in liver

(2018) Piotr Zabielski et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling

(2018) Yancun Yin et al.   PATHOLOGY RESEARCH AND PRACTICE

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

(2018) David Fernández-Ramos et al.   Cell Death & Disease

Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice

(2018) Natalia Presa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

(2018) Hirokazu Takahashi et al.   Frontiers in Endocrinology

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

(2018) Imanol Zubiete-Franco et al.   EBioMedicine

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis

(2017) Cristina Alonso et al.   GASTROENTEROLOGY

Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics

(2017) Zhao Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Associations of systemic sphingolipids with measures of hepatic function in liver cirrhosis are related to cholesterol

(2017) Sabrina Krautbauer et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study

(2017) Rosina Critelli et al.   Cell Death & Disease

Identification of key metabolic changes during liver fibrosis progression in rats using a urine and serum metabolomics approach

(2017) Hong Chang et al.   Scientific Reports

Sphingosine 1-Phosphate Receptors: Do They Have a Therapeutic Potential in Cardiac Fibrosis?

(2017) Ambra Vestri et al.   Frontiers in Pharmacology

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

Deregulated neddylation in liver fibrosis

(2016) Imanol Zubiete-Franco et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis

(2016) Imanol Zubiete-Franco et al.   JOURNAL OF HEPATOLOGY

Metabolic Profile Changes of CCl4-Liver Fibrosis and Inhibitory Effects of Jiaqi Ganxian Granule

(2016) Ge Wang et al.   MOLECULES

Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways

(2015) Carla Hajj et al.   BIOLOGICAL CHEMISTRY

Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels

(2015) Olivier Govaere et al.   Clinics in Liver Disease

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

(2015) Lucía Barbier-Torres et al.   HEPATOLOGY

Current efforts and trends in the treatment of NASH

(2015) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

(2015) D. Lee Gorden et al.   JOURNAL OF LIPID RESEARCH

DNA damage response and sphingolipid signaling in liver diseases

(2015) Masayuki Nagahashi et al.   SURGERY TODAY

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer

(2015) Lucía Barbier-Torres et al.   Oncotarget

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis

(2015) Georgios Grammatikos et al.   PLoS One

Phosphatidic acid inhibits ceramide 1-phosphate-stimulated macrophage migration

(2014) Alberto Ouro et al.   BIOCHEMICAL PHARMACOLOGY

Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease

(2014) Georgios Grammatikos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration

(2013) Lide Arana et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sphingolipid homeostasis in the web of metabolic routes

(2013) Auxiliadora Aguilera-Romero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

(2013) Susann Fayyaz et al.   DIABETOLOGIA

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Hepatocellular carcinoma and sorafenib: too many resistance mechanisms?

(2013) Carmen Berasain   GUT

Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides

(2013) Resat Cinar et al.   HEPATOLOGY

p27 Is a Critical Prognostic Biomarker in Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma

(2013) Yasunobu Matsuda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidemiology of Hepatocellular Carcinoma

(2013) Sahil Mittal et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer

(2013) Radoslav Savić et al.   PLoS One

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Ceramide and Apoptosis: Exploring the Enigmatic Connections between Sphingolipid Metabolism and Programmed Cell Death

(2012) Thomas D. Mullen et al.   Anti-Cancer Agents in Medicinal Chemistry

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules

(2012) SHI-QUAN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Global Epidemiology of Hepatocellular Carcinoma: Present and Future

(2011) Katherine A. McGlynn et al.   Clinics in Liver Disease

Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats

(2011) Li Chun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

(2011) Ainara Cano et al.   HEPATOLOGY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis

(2010) Anna Moles et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry

(2010) Takhar Kasumov et al.   ANALYTICAL BIOCHEMISTRY

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

Sphingosine-1-Phosphate Activates the AKT Pathway to Protect Small Intestines from Radiation-Induced Endothelial Apoptosis

(2010) S. Bonnaud et al.   CANCER RESEARCH

Epidemiology of Non-Alcoholic Fatty Liver Disease

(2010) Stefano Bellentani et al.   DIGESTIVE DISEASES

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential roles of sphingosine 1-phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation

(2010) Xihong Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility

(2010) Changyong Li et al.   JOURNAL OF HEPATOLOGY

Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis

(2010) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei

(2010) Grzegorz Chocian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

(2010) Patricia Gangoiti et al.   PROGRESS IN LIPID RESEARCH

Endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2

(2010) Zhi-Qiang Chang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Involvement of Sphingosine 1-Phosphate (SIP)/S1P 3 Signaling in Cholestasis-Induced Liver Fibrosis

(2009) Changyong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

(2009) Wei Hu et al.   JOURNAL OF LIPID RESEARCH

Lysosomal ceramide mediates gemcitabine-induced death of glioma cells

(2009) Claudia A. Dumitru et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum

(2009) Anna Kotronen et al.   Obesity

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

(2008) Montserrat Marí et al.   GASTROENTEROLOGY

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

(2008) Gergana M. Deevska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways

(2007) Patricia Gangoiti et al.   CELLULAR SIGNALLING

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY