- Home
- Publications
- Publication Search
- Publication Details
Title
Drug Promiscuity in PDB: Protein Binding Site Similarity Is Key
Authors
Keywords
-
Journal
PLoS One
Volume 8, Issue 6, Pages e65894
Publisher
Public Library of Science (PLoS)
Online
2013-06-22
DOI
10.1371/journal.pone.0065894
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Drug repositioning through incomplete bi-cliques in an integrated drug–target–disease network
- (2012) Simone Daminelli et al. Integrative Biology
- ProBiS-Database: Precalculated Binding Site Similarities and Local Pairwise Alignments of PDB Structures
- (2012) Janez Konc et al. Journal of Chemical Information and Modeling
- Use of genome-wide association studies for drug repositioning
- (2012) Philippe Sanseau et al. NATURE BIOTECHNOLOGY
- Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs
- (2011) Lei Xie et al. Annual Review of Pharmacology and Toxicology
- Old friends in new guise: repositioning of known drugs with structural bioinformatics
- (2011) V. J. Haupt et al. BRIEFINGS IN BIOINFORMATICS
- Molecular complexity and fragment-based drug discovery: ten years on
- (2011) Andrew R Leach et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients
- (2011) Jörg-Christian Heinrich et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Probing the links between in vitro potency, ADMET and physicochemical parameters
- (2011) M. Paul Gleeson et al. NATURE REVIEWS DRUG DISCOVERY
- Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
- (2011) J. T. Dudley et al. Science Translational Medicine
- Combinations of Protein-Chemical Complex Structures Reveal New Targets for Established Drugs
- (2011) Olga V. Kalinina et al. PLoS Computational Biology
- Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir
- (2011) Li Xie et al. PLoS Computational Biology
- Using Multiple Microenvironments to Find Similar Ligand-Binding Sites: Application to Kinase Inhibitor Binding
- (2011) Tianyun Liu et al. PLoS Computational Biology
- Chemoinformatic Analysis of Biologically Active Macrocycles
- (2010) Wolfgang Brandt et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- PubChem as a public resource for drug discovery
- (2010) Qingliang Li et al. DRUG DISCOVERY TODAY
- The Comparative Toxicogenomics Database: update 2011
- (2010) A. P. Davis et al. NUCLEIC ACIDS RESEARCH
- DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
- (2010) C. Knox et al. NUCLEIC ACIDS RESEARCH
- Unveiling the role of network and systems biology in drug discovery
- (2010) Albert Pujol et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications
- (2010) Sarah L. Kinnings et al. PLoS Computational Biology
- A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery
- (2009) L. Xie et al. BIOINFORMATICS
- Properties and identification of human protein drug targets
- (2009) Tala M. Bakheet et al. BIOINFORMATICS
- Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds
- (2009) Jens-Uwe Peters et al. ChemMedChem
- The topology of drug–target interaction networks: implicit dependence on drug properties and target families
- (2009) Jordi Mestres et al. Molecular BioSystems
- Protein promiscuity and its implications for biotechnology
- (2009) Irene Nobeli et al. NATURE BIOTECHNOLOGY
- Update of TTD: Therapeutic Target Database
- (2009) Feng Zhu et al. NUCLEIC ACIDS RESEARCH
- The Pfam protein families database
- (2009) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
- Small Molecule Subgraph Detector (SMSD) toolkit
- (2009) Syed Rahman et al. Journal of Cheminformatics
- Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
- (2009) Li Xie et al. PLoS Computational Biology
- Detection of 3D atomic similarities and their use in the discrimination of small molecule protein-binding sites
- (2008) R. Najmanovich et al. BIOINFORMATICS
- Structural Characterization of Myotoxic Ecarpholin S From Echis carinatus Venom
- (2008) Xingding Zhou et al. BIOPHYSICAL JOURNAL
- Pybel: a Python wrapper for the OpenBabel cheminformatics toolkit
- (2008) Noel M O'Boyle et al. Chemistry Central Journal
- How to Measure the Similarity Between Protein Ligand-Binding Sites?
- (2008) Esther Kellenberger et al. Current Computer-Aided Drug Design
- Suramin: Clinical Uses and Structure-Activity Relationships
- (2008) Ross McGeary et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Network pharmacology: the next paradigm in drug discovery
- (2008) Andrew L Hopkins Nature Chemical Biology
- Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments
- (2008) L. Xie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A simple and fuzzy method to align and compare druggable ligand-binding sites
- (2008) Claire Schalon et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started