Complement interactions with the pathogenic Neisseriae: clinical features, deficiency states, and evasion mechanisms

Differential effects of therapeutic complement Inhibitors on serum bactericidal activity against nongroupable meningococcal isolates recovered from patients treated with eculizumab

(2019) Dan M. Granoff et al.   HAEMATOLOGICA

Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis

(2019) Gérard Socié et al.   BRITISH JOURNAL OF HAEMATOLOGY

Invasive meningococcal disease in patients with complement deficiencies: a case series (2008–2017)

(2019) Shamez N. Ladhani et al.   BMC INFECTIOUS DISEASES

A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine

(2019) Peter T. Beernink et al.   mBio

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

(2019) Sunita Gulati et al.   PLOS BIOLOGY

The gonococcal Neisserial Heparin Binding Antigen (NHBA) is involved in microcolony formation and contributes to serum resistance and adherence to epithelial cells

(2019) Evgeny A Semchenko et al.   JOURNAL OF INFECTIOUS DISEASES

The hijackers guide to escaping complement: Lessons learned from pathogens

(2019) David Ermert et al.   MOLECULAR IMMUNOLOGY

A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity

(2018) Sanjay Ram et al.   INFECTION AND IMMUNITY

Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae

(2018) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

No Good Deed Goes Unpunished: Eculizumab and Invasive Neisserial Infections

(2018) Daniel P McQuillen et al.   CLINICAL INFECTIOUS DISEASES

Disseminated Gonococcal Infections in Patients Receiving Eculizumab: A Case Series

(2018) Page E Crew et al.   CLINICAL INFECTIOUS DISEASES

Meningococcal B vaccine (4CMenB): the journey from research to real world experience

(2018) Rino Rappuoli et al.   Expert Review of Vaccines

Unusual Neisseria species as a cause of infection in patients taking eculizumab

(2018) Page E. Crew et al.   JOURNAL OF INFECTION

A meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and overexpressed Factor H binding protein elicits gonococcal bactericidal antibodies

(2018) Peter T Beernink et al.   JOURNAL OF INFECTIOUS DISEASES

A Bivalent Meningococcal B Vaccine in Adolescents and Young Adults

(2017) Lars Ostergaard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Subversion of nutritional immunity by the pathogenic Neisseriae

(2017) Cynthia Nau Cornelissen   Pathogens and Disease

High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine

(2017) Lucy A. McNamara et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope Specificity

(2016) S. Giuntini et al.   Clinical and Vaccine Immunology

Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae

(2016) Sanjay Ram et al.   IMMUNOBIOLOGY

A Novel Factor H–Fc Chimeric Immunotherapeutic Molecule againstNeisseria gonorrhoeae

(2016) Jutamas Shaughnessy et al.   JOURNAL OF IMMUNOLOGY

Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

(2015) Serena Giuntini et al.   INFECTION AND IMMUNITY

Antibody to Reduction Modifiable Protein Increases the Bacterial Burden and the Duration of Gonococcal Infection in a Mouse Model

(2015) Sunita Gulati et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine

(2015) Serena Giuntini et al.   VACCINE

Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

(2015) Sunita Gulati et al.   PLoS Pathogens

Mannose-binding lectin gene,MBL2, polymorphisms do not increase susceptibility to invasive meningococcal disease in a population of Danish children

(2015) Lene F. Lundbo et al.   Open Forum Infectious Diseases

MBL2 deficiency is associated with higher genomic bacterial loads during meningococcemia in young children

(2014) T.C. Darton et al.   CLINICAL MICROBIOLOGY AND INFECTION

Inhibition of the Alternative Pathway of Nonhuman Infant Complement by Porin B2 Contributes to Virulence of Neisseria meningitidis in the Infant Rat Model

(2014) L. A. Lewis et al.   INFECTION AND IMMUNITY

Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing

(2014) Timothy J. Wells et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Factor H Interacts Selectively with Neisseria gonorrhoeae and Results in Species-Specific Complement Evasion

(2014) J. Ngampasutadol et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides

(2014) Sarika Agarwal et al.   JOURNAL OF IMMUNOLOGY

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Structure-Function Studies of the Neisseria gonorrhoeae Major Outer Membrane Porin

(2013) Adrienne Chen et al.   INFECTION AND IMMUNITY

Deficiency in Complement Factor B

(2013) Charlotte Slade et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum

(2013) E. Del Tordello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis

(2013) L. A. Lewis et al.   mBio

Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation

(2012) Göran Jönsson et al.   CLINICAL IMMUNOLOGY

Phosphoethanolamine Residues on the Lipid A Moiety of Neisseria gonorrhoeae Lipooligosaccharide Modulate Binding of Complement Inhibitors and Resistance to Complement Killing

(2012) Lisa A. Lewis et al.   INFECTION AND IMMUNITY

The Relative Roles of Factor H Binding Protein, Neisserial Surface Protein A, and Lipooligosaccharide Sialylation in Regulation of the Alternative Pathway of Complement on Meningococci

(2012) L. A. Lewis et al.   JOURNAL OF IMMUNOLOGY

Properdin Is Critical for Antibody-Dependent Bactericidal Activity against Neisseria gonorrhoeae That Recruit C4b-Binding Protein

(2012) S. Gulati et al.   JOURNAL OF IMMUNOLOGY

The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein

(2012) Peter T. Beernink et al.   PLoS Pathogens

Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein

(2011) Serena Giuntini et al.   INFECTION AND IMMUNITY

Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding

(2011) Serena Giuntini et al.   INFECTION AND IMMUNITY

Meningococcal Group W-135 and Y Capsular Polysaccharides Paradoxically Enhance Activation of the Alternative Pathway of Complement

(2011) Sanjay Ram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Blocking Human IgG Directed against the Pentapeptide Repeat Motifs of Neisseria meningitidis Lip/H.8 and Laz Lipoproteins

(2011) T. Dutta Ray et al.   JOURNAL OF IMMUNOLOGY

A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination

(2011) P. T. Beernink et al.   JOURNAL OF IMMUNOLOGY

Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance

(2011) Natalie J. Griffiths et al.   MOLECULAR MICROBIOLOGY

Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection

(2011) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

(2011) S. Agarwal et al.   mBio

Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections

(2011) Ann E. Jerse et al.   Frontiers in Microbiology

Prevalence of hereditary properdin, C7 and C8 deficiencies in patients with meningococcal infections

(2010) M. SCHLESINGER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Binding of mannan-binding protein to various bacterial pathogens of meningitis

(2010) L. C. EMMERIK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infections of People with Complement Deficiencies and Patients Who Have Undergone Splenectomy

(2010) S. Ram et al.   CLINICAL MICROBIOLOGY REVIEWS

Opacity Proteins Increase Neisseria gonorrhoeae Fitness in the Female Genital Tract Due to a Factor under Ovarian Control

(2010) J. G. Cole et al.   INFECTION AND IMMUNITY

Factor H Facilitates Adherence of Neisseria gonorrhoeae to Complement Receptor 3 on Eukaryotic Cells

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans

(2010) Davide Serruto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

(2010) S. K. Alex Law et al.   PROTEIN SCIENCE

Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults

(2010) C. A. MacLennan et al.   SCIENCE

Neisseria meningitidis Opc Invasin Binds to the Sulphated Tyrosines of Activated Vitronectin to Attach to and Invade Human Brain Endothelial Cells

(2010) Claudia Sa E Cunha et al.   PLoS Pathogens

The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to Complement

(2010) Lisa A. Lewis et al.   PLoS Pathogens

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature

(2009) K. T. Lappegard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera

(2008) D. M. Granoff et al.   INFECTION AND IMMUNITY

Phosphoethanolamine Substitution of Lipid A and Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides and Complement-Mediated Killing by Normal Human Serum

(2008) L. A. Lewis et al.   INFECTION AND IMMUNITY

Understanding Systemic Lupus Erythematosus Physiopathology in the Light of Primary Immunodeficiencies

(2008) Magda Carneiro-Sampaio et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A generic mechanism inNeisseria meningitidisfor enhanced resistance against bactericidal antibodies

(2008) Maria Jose Uria et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement‐Dependent Synergistic Bactericidal Activity of Antibodies against Factor H–Binding Protein, a Sparsely Distributed Meningococcal Vaccine Antigen

(2008) Jo Anne Welsch et al.   JOURNAL OF INFECTIOUS DISEASES