Journal
CLINICAL IMMUNOLOGY
Volume 144, Issue 3, Pages 214-227Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2012.06.008
Keywords
The complement system; C2 deficiency; Invasive infection; Vaccination; Opsonization; Phagocytosis
Categories
Funding
- Swedish Research Council [15092, 13489]
- Swedish Rheumatism Association
- Medical Faculty of Lund University
- Alfred Osterlund Foundation
- Crafoord Foundation
- Greta and Johan Kock Foundations
- King Gustaf V's 80th Birthday Foundation
- Lund University Hospital
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Hereditary C2 deficiency (C2D) is an important susceptibility factor for invasive infections caused by encapsulated bacteria such as pneumococci and Haemophilus influenzae type b. The infections are mostly seen in childhood indicating that antibody-mediated acquired immunity is affected. C2D persons and healthy controls were vaccinated with ActHIB (R) and Pneumo23 (R). Analysis of specific antibodies to pneumococci serotype 6B, 7F, and 23F, and Hib was performed. Post-vaccination IgG antibodies against pneumococci serotype 6B and 23F at a concentration >= 1.0 mg/L was found in similar frequency in C2D persons and controls. Post-vaccination sera from C2D persons showed poor complement-mediated opsonization and phagocytosis of pneumococci by granulocytes when depending on classical and lectin pathway activation only, but increased (p=0.007) and equaled that of the normal controls when also alternative pathway activation was allowed due to antibody-dependent C2 bypass activation. In conclusion, the C2D persons benefited from the vaccination and achieve an increased phagocytic capacity. (c) 2012 Elsevier Inc. All rights reserved.
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