Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions

Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

(2018) Hai-Qin Huo et al.   Stem Cell Reports

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions

(2017) Elias Uhlin et al.   Stem Cell Research

The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene

(2017) Elizabeth D. Justice et al.   PLoS Genetics

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Integrins in synapse regulation

(2016) Yun Kyung Park et al.   NATURE REVIEWS NEUROSCIENCE

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

(2016) Manja Wachsmuth et al.   PLoS Genetics

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation

(2016) Tomer Halevy et al.   Stem Cell Reports

Transient RUNX1 Expression during Early Mesendodermal Differentiation of hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling

(2016) Jennifer J. VanOudenhove et al.   Stem Cell Reports

An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome

(2016) Faycal Guedj et al.   Scientific Reports

DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model

(2015) N. Kurabayashi et al.   EMBO REPORTS

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

DNA-Methylation Patterns in Trisomy 21 Using Cells from Monozygotic Twins

(2015) M. Reza Sailani et al.   PLoS One

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

(2015) Aoife Murray et al.   STEM CELLS

Methods of Reprogramming to Induced Pluripotent Stem Cell Associated with Chromosomal Integrity and Delineation of a Chromosome 5q Candidate Region for Growth Advantage

(2015) Maria Sobol et al.   STEM CELLS AND DEVELOPMENT

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells

(2014) Siqin Wu et al.   BIOMATERIALS

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells

(2014) Chen Chen et al.   Nature Communications

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21

(2013) Youssef Hibaoui et al.   EMBO Molecular Medicine

Multiplex Genetic Fate Mapping Reveals a Novel Route of Neocortical Neurogenesis, Which Is Altered in the Ts65Dn Mouse Model of Down Syndrome

(2013) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Deficits in human trisomy 21 iPSCs and neurons

(2013) J. P. Weick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

(2012) Jie Lu et al.   HUMAN MOLECULAR GENETICS

Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons

(2012) Anna Falk et al.   PLoS One

A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

(2012) Y. Shi et al.   Science Translational Medicine

Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

(2012) James A. Briggs et al.   STEM CELLS

Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes

(2011) Mireia Vilardell et al.   BMC GENOMICS

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

(2008) Karen Bonde Larsen et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER