Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

(2018) Dannielle DeWaal et al.   Nature Communications

Pancreatic cancer incidence trends: evidence from the Surveillance, Epidemiology and End Results (SEER) population-based data

(2017) Vanessa L Gordon-Dseagu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

(2017) Wei Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Improving post-surgical management of resected pancreatic cancer

(2017) Stefan Boeck et al.   LANCET

Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase

(2017) He-Lin Yu et al.   Scientific Reports

Mechanism of antineoplastic activity of lonidamine

(2016) Kavindra Nath et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Nurture of Tumors Can Drive Their Metabolic Phenotype

(2016) Zachary T. Schug et al.   Cell Metabolism

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis

(2016) Sarah R. Elkin et al.   TRAFFIC

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

(2016) Hong Lin et al.   ACS Medicinal Chemistry Letters

Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer

(2016) Zhou Du et al.   Nature Communications

Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin

(2016) Min-Juan XU et al.   Scientific Reports

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Heterologous Reconstitution of Ikarugamycin Biosynthesis inE. coli

(2014) Janine Antosch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis

(2014) Guangtao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis

(2014) Rodney Lacret et al.   Marine Drugs

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Target identification of small molecules based on chemical biology approaches

(2013) Yushi Futamura et al.   Molecular BioSystems

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Glycolysis Back in the Limelight: Systemic Targeting of HK2 Blocks Tumor Growth

(2013) S. Ros et al.   Cancer Discovery

Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II

(2013) Barbara Salani et al.   Scientific Reports

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells

(2011) Ruxandra Popescu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY