Presence and structure‐activity relationship of intrinsically disordered regions across mucins

FunSet: an open-source software and web server for performing and displaying Gene Ontology enrichment analysis

(2019) Matthew L. Hale et al.   BMC BIOINFORMATICS

Why do eukaryotic proteins contain more intrinsically disordered regions?

(2019) Walter Basile et al.   PLoS Computational Biology

MUC16 as a Novel Target for Cancer Therapy

(2018) Abhijit Aithal et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients

(2018) Thaïs Baert et al.   GYNECOLOGIC ONCOLOGY

Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mucin Expression in Colorectal Cancer (CRC)

(2018) Yaron Niv et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm

(2018) K. Tsafou et al.   JOURNAL OF MOLECULAR BIOLOGY

Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation

(2018) Jianhong Zhou et al.   JOURNAL OF MOLECULAR BIOLOGY

O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2

(2018) Pei-Wen Lo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target

(2018) Ravi Salgia et al.   Journal of Clinical Medicine

Mucins: the frontline defence of the lung

(2018) Caroline Ridley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mucin 2 (MUC2) promoter characterization: an overview

(2018) Melissa Shizue de A. Yamashita et al.   CELL AND TISSUE RESEARCH

Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions

(2017) Gang Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

(2017) Yuan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer

(2017) Jos P.M. van Putten et al.   Journal of Innate Immunity

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

(2017) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

First Experimental Assessment of Protein Intrinsic Disorder Involvement in an RNA Virus Natural Adaptive Process

(2017) Justine Charon et al.   MOLECULAR BIOLOGY AND EVOLUTION

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study

(2016) Sukhwinder Kaur et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

(2016) Shiv Ram Krishn et al.   CANCER LETTERS

Mucins and Wnt/β-catenin signaling in gastrointestinal cancers: an unholy nexus

(2016) Priya Pai et al.   CARCINOGENESIS

PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility

(2016) Gayane Machkalyan et al.   CELLULAR SIGNALLING

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

(2016) Vladimir Uversky   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Searching the Evolutionary Origin of Epithelial Mucus Protein Components—Mucins and FCGBP

(2016) Tiange Lang et al.   MOLECULAR BIOLOGY AND EVOLUTION

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures

(2016) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2017 update

(2016) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

(2016) Wouter Boomsma et al.   PeerJ

Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction

(2016) Jérôme Bürgi et al.   PLoS One

Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc

(2016) Chen Yu et al.   Scientific Reports

Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships

(2015) Sukriti Goyal et al.   BMC GENOMICS

Targeting intrinsically disordered proteins in rational drug discovery

(2015) Susmitha Ambadipudi et al.   Expert Opinion on Drug Discovery

In Silico Analysis of Correlations between Protein Disorder and Post-Translational Modifications in Algae

(2015) Atsushi Kurotani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional assessment of intrinsic disorder central domains of BRCA1

(2015) Lumbini R. Yadav et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

(2015) Kwan-Young Jung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach

(2015) Prerna Malaney et al.   METHODS

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma membrane-associated platforms: Dynamic scaffolds that organize membrane-associated events

(2015) V. Astro et al.   Science Signaling

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

(2015) Imayavaramban Lakshmanan et al.   Oncotarget

Plasma membrane-associated platforms: Dynamic scaffolds that organize membrane-associated events

(2015) V. Astro et al.   Science Signaling

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target

(2015) Deepak Raina et al.   PLoS One

Computational Identification of MoRFs in Protein Sequences Using Hierarchical Application of Bayes Rule

(2015) Nawar Malhis et al.   PLoS One

Comprehensive large-scale assessment of intrinsic protein disorder

(2014) Ian Walsh et al.   BIOINFORMATICS

A Critical Evaluation of in silico Methods for Detection of Membrane Protein Intrinsic Disorder

(2014) Edward E. Pryor et al.   BIOPHYSICAL JOURNAL

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

(2014) Vladimir N. Uversky et al.   CHEMICAL REVIEWS

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Quantitative Glycoproteomics Analysis Reveals Changes in N-Glycosylation Level Associated with Pancreatic Ductal Adenocarcinoma

(2014) Sheng Pan et al.   JOURNAL OF PROTEOME RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

(2014) Robin van der Lee et al.   Cell Reports

Intrinsic Structural Disorder in Cytoskeletal Proteins

(2013) Mainak Guharoy et al.   Cytoskeleton

Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology

(2013) Catharina Steentoft et al.   EMBO JOURNAL

Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device

(2013) Thaher Pelaseyed et al.   FEBS Journal

MUC15 Inhibits Dimerization of EGFR and PI3K–AKT Signaling and Is Associated With Aggressive Hepatocellular Carcinomas in Patients

(2013) Ruo–Yu Wang et al.   GASTROENTEROLOGY

MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways

(2013) HIROTAKA HOSHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mucins in pancreatic cancer and its microenvironment

(2013) Sukhwinder Kaur et al.   Nature Reviews Gastroenterology & Hepatology

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle regulation by the intrinsically disordered proteins p21 and p27

(2012) Mi-Kyung Yoon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Computational prediction of N-linked glycosylation incorporating structural properties and patterns

(2012) Gwo-Yu Chuang et al.   BIOINFORMATICS

Disorder-function relationships for the cell cycle regulatory proteins p21 and p27

(2012) Diana M. Mitrea et al.   BIOLOGICAL CHEMISTRY

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life

(2012) Bin Xue et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

D2P2: database of disordered protein predictions

(2012) Matt E. Oates et al.   NUCLEIC ACIDS RESEARCH

Mucin 16 is a functional selectin ligand on pancreatic cancer cells

(2011) Shih-Hsun Chen et al.   FASEB JOURNAL

A majority of the cancer/testis antigens are intrinsically disordered proteins

(2011) Krithika Rajagopalan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Protein intrinsic disorder and induced pluripotent stem cells

(2011) Bin Xue et al.   Molecular BioSystems

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Proline-Rich Salivary Proteins Have Extended Conformations

(2010) Hélène Boze et al.   BIOPHYSICAL JOURNAL

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Hub Promiscuity in Protein-Protein Interaction Networks

(2010) Ashwini Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cells

(2010) S Bafna et al.   ONCOGENE

ANCHOR: web server for predicting protein binding regions in disordered proteins

(2009) Z. Dosztanyi et al.   BIOINFORMATICS

Intrinsic Protein Disorder and Interaction Promiscuity Are Widely Associated with Dosage Sensitivity

(2009) Tanya Vavouri et al.   CELL

Disorder, Promiscuity, and Toxic Partnerships

(2009) Edward M. Marcotte et al.   CELL

The rules of disorder or why disorder rules

(2009) Jörg Gsponer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Modularity of intrinsic disorder in the human proteome

(2009) Melissa M. Pentony et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mucin-interacting proteins: from function to therapeutics

(2009) Shantibhusan Senapati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data

(2009) Yvonne JK Edwards et al.   GENOME BIOLOGY

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Regulation of Cell Division by Intrinsically Unstructured Proteins: Intrinsic Flexibility, Modularity, and Signaling Conduits†

(2008) Charles A. Galea et al.   BIOCHEMISTRY

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells

(2008) P. Chaturvedi et al.   CANCER RESEARCH

Clinical potential of mucins in diagnosis, prognosis, and therapy of ovarian cancer

(2008) Ajay P Singh et al.   LANCET ONCOLOGY