Emerging small and large molecule therapeutics for respiratory syncytial virus
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Title
Emerging small and large molecule therapeutics for respiratory syncytial virus
Authors
Keywords
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Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume -, Issue -, Pages 1-10
Publisher
Informa UK Limited
Online
2020-02-25
DOI
10.1080/13543784.2020.1735349
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Note: Only part of the references are listed.- Antibody responses to viral infections: a structural perspective across three different enveloped viruses
- (2019) Charles D. Murin et al. Nature Microbiology
- Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial
- (2019) Khalid Alansari et al. PEDIATRICS
- Nanobody: outstanding features for diagnostic and therapeutic applications
- (2019) J.-Pablo Salvador et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
- (2019) Egor Tchesnokov et al. Viruses-Basel
- Recent Trends in RSV Immunoprophylaxis: Clinical Implications for the Infant
- (2019) Santiago Acero-Bedoya et al. AMERICAN JOURNAL OF PERINATOLOGY
- Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference
- (2019) John H. Beigel et al. ANTIVIRAL RESEARCH
- Respiratory syncytial virus in hematopoietic cell transplant recipients and patients with hematologic malignancies
- (2019) Fareed Khawaja et al. HAEMATOLOGICA
- Treatment stratification of respiratory syncytial virus infection in allogeneic stem cell transplantation
- (2019) Katalin Balassa et al. JOURNAL OF INFECTION
- Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor
- (2019) Xiufang Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development
- (2019) Seyhan Boyoglu-Barnum et al. Frontiers in Immunology
- Risk of Childhood Wheeze and Asthma after Respiratory Syncytial Virus Infection in Full‐Term Infants
- (2019) Asuncion Mejias et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Antibiotic Minocycline Prevents Respiratory Syncytial Virus Infection
- (2019) Swapnil S. Bawage et al. Viruses-Basel
- Human Antiviral Efficacy, Safety and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein: A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Challenge Study
- (2019) John DeVincenzo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Freesia Study Design: JNJ-53718678 in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Upper Respiratory Tract
- (2019) Roy Chemaly et al. BLOOD
- Manufacturing process optimization of ADMA Biologics' intravenous immunoglobulin products, BIVIGAM® and ASCENIV™
- (2019) Richard L Wasserman et al. Immunotherapy
- CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung
- (2019) Christopher S. Anderson et al. PEDIATRIC RESEARCH
- A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein
- (2019) Aimin Tang et al. Nature Communications
- Subversion of Host Cell Mitochondria by RSV to Favor Virus Production is Dependent on Inhibition of Mitochondrial Complex I and ROS Generation
- (2019) MengJie Hu et al. Cells
- A Phase II, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients
- (2019) Roy F Chemaly et al. CLINICAL INFECTIOUS DISEASES
- Anti-respiratory syncytial virus (RSV) G monoclonal antibodies reduce lung inflammation and viral lung titers when delivered therapeutically in a BALB/c mouse model
- (2018) Hayat Caidi et al. ANTIVIRAL RESEARCH
- Burden of severe RSV disease among immunocompromised children and adults: a 10 year retrospective study
- (2018) Olga Chatzis et al. BMC INFECTIOUS DISEASES
- Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
- (2018) Daniel W Brookes et al. BRITISH JOURNAL OF PHARMACOLOGY
- Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium
- (2018) Carmen Mirabelli et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study
- (2018) Marita Stevens et al. JOURNAL OF INFECTIOUS DISEASES
- A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study
- (2018) Joanne M Langley et al. JOURNAL OF INFECTIOUS DISEASES
- Prevalence and Significance of Substitutions in the Fusion Protein of Respiratory Syncytial Virus Resulting in Neutralization Escape From Antibody MEDI8897
- (2018) Qing Zhu et al. JOURNAL OF INFECTIOUS DISEASES
- Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo
- (2018) Shamir R. Jacobino et al. mAbs
- Delivery of ALX-0171 by inhalation greatly reduces respiratory syncytial virus disease in newborn lambs
- (2018) Alejandro Larios Mora et al. mAbs
- Safety, Tolerability, and Pharmacokinetics of MEDI8897, an Extended Half-Life Single-Dose Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants
- (2018) Joseph B. Domachowske et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses
- (2018) et al. Viruses-Basel
- Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies
- (2018) Harrison G. Jones et al. PLoS Pathogens
- Respiratory syncytial virus prevention and asthma in healthy preterm infants: a randomised controlled trial
- (2018) Nienke M Scheltema et al. Lancet Respiratory Medicine
- Patisiran: First Global Approval
- (2018) Sheridan M. Hoy DRUGS
- The Morphology and Assembly of Respiratory Syncytial Virus Revealed by Cryo-Electron Tomography
- (2018) Zunlong Ke et al. Viruses-Basel
- Neuraminidase inhibitor resistance in influenza
- (2018) Nelson Lee et al. CURRENT OPINION IN INFECTIOUS DISEASES
- RI-002, an intravenous immunoglobulin containing high titer neutralizing antibody to RSV and other respiratory viruses for use in primary immunodeficiency disease and other immune compromised populations
- (2017) Richard L. Wasserman et al. Expert Review of Clinical Immunology
- The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin
- (2017) Young-In Kim et al. Influenza and Other Respiratory Viruses
- IVIG-mediated effector functions in autoimmune and inflammatory diseases
- (2017) Caroline Galeotti et al. INTERNATIONAL IMMUNOLOGY
- Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective
- (2017) S. Boyoglu-Barnum et al. JOURNAL OF VIROLOGY
- Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases
- (2017) Gino Van Heeke et al. PHARMACOLOGY & THERAPEUTICS
- Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development
- (2017) José A. Melero et al. VACCINE
- Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
- (2017) Dirk Roymans et al. Nature Communications
- Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection
- (2017) Bernhard Resch Human Vaccines & Immunotherapeutics
- Generation of Murine Monoclonal Antibodies by Hybridoma Technology
- (2017) Pamela Holzlöhner et al. Jove-Journal of Visualized Experiments
- Respiratory syncytial virus: prospects for new and emerging therapeutics
- (2017) Patricia A. Jorquera et al. Expert Review of Respiratory Medicine
- Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook
- (2017) Mehdi Arbabi-Ghahroudi Frontiers in Immunology
- Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B
- (2017) Anne M. Hause et al. PLoS One
- GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses
- (2017) Michael K. Lo et al. Scientific Reports
- Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection
- (2016) Concepción Palomo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Engineering antibody therapeutics
- (2016) Mark L Chiu et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV
- (2016) Ivy Widjaja et al. JOURNAL OF VIROLOGY
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
- (2016) Travis K. Warren et al. NATURE
- Challenges and opportunities in RSV vaccine development: Meeting report from FDA/NIH workshop
- (2016) Jeffrey N. Roberts et al. VACCINE
- GS-5806 Inhibits Pre- to Postfusion Conformational Changes of the Respiratory Syncytial Virus Fusion Protein
- (2015) Dharmaraj Samuel et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- GS-5806 Inhibits a Broad Range of Respiratory Syncytial Virus Clinical Isolates by Blocking the Virus-Cell Fusion Process
- (2015) Michel Perron et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection
- (2015) Laurent Detalle et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β
- (2015) Abhijeet Bakre et al. JOURNAL OF GENERAL VIROLOGY
- CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells
- (2015) Tatiana Chirkova et al. JOURNAL OF GENERAL VIROLOGY
- Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics
- (2015) E. A. F. Simoes et al. JOURNAL OF INFECTIOUS DISEASES
- Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection
- (2015) Guangyi Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter
- (2015) Sarah L. Noton et al. JOURNAL OF VIROLOGY
- Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study
- (2015) John P. DeVincenzo et al. NEW ENGLAND JOURNAL OF MEDICINE
- An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice
- (2015) Seyhan Boyoglu-Barnum et al. VIROLOGY
- Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein
- (2015) Jason S McLellan Current Opinion in Virology
- Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
- (2015) Jerome Deval et al. PLoS Pathogens
- Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures
- (2015) Sara M. Johnson et al. PLoS Pathogens
- Characterization of a Respiratory Syncytial Virus L Protein Inhibitor
- (2014) Choi-Lai Tiong-Yip et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Mechanism of Action for Respiratory Syncytial Virus Inhibitor RSV604
- (2014) SreeRupa Challa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein
- (2014) B. Schepens et al. EMBO Molecular Medicine
- Verdinexor, a Novel Selective Inhibitor of Nuclear Export, Reduces Influenza A Virus Replication In Vitro and In Vivo
- (2014) O. Perwitasari et al. JOURNAL OF VIROLOGY
- Prophylaxis with a Respiratory Syncytial Virus (RSV) Anti-G Protein Monoclonal Antibody Shifts the Adaptive Immune Response to RSV rA2-line19F Infection from Th2 to Th1 in BALB/c Mice
- (2014) S. Boyoglu-Barnum et al. JOURNAL OF VIROLOGY
- Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study
- (2014) John P. DeVincenzo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection
- (2014) PEDIATRICS
- Preclinical Evaluation of the Novel, Orally Bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in Spontaneous Canine Cancer: Results of a Phase I Study
- (2014) Cheryl A. London et al. PLoS One
- Immunity to RSV in Early-Life
- (2014) Laura Lambert et al. Frontiers in Immunology
- A Respiratory Syncytial Virus (RSV) Anti-G Protein F(ab')2 Monoclonal Antibody Suppresses Mucous Production and Breathing Effort in RSV rA2-line19F-Infected BALB/c Mice
- (2013) S. Boyoglu-Barnum et al. JOURNAL OF VIROLOGY
- Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness
- (2013) Octavio Ramilo et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody
- (2013) J. S. McLellan et al. SCIENCE
- RSV Fusion: Time for a New Model
- (2013) Peter Mastrangelo et al. Viruses-Basel
- Combination Therapy Using Monoclonal Antibodies against Respiratory Syncytial Virus (RSV) G Glycoprotein Protects from RSV Disease in BALB/c Mice
- (2012) Hayat Caidi et al. PLoS One
- Therapeutic targeting of respiratory syncytial virus G-protein
- (2010) Lawrence M Kauvar et al. Immunotherapy
- Prophylactic Treatment with a G Glycoprotein Monoclonal Antibody Reduces Pulmonary Inflammation in Respiratory Syncytial Virus (RSV)-Challenged Naive and Formalin-Inactivated RSV-Immunized BALB/c Mice
- (2010) G. U. Radu et al. JOURNAL OF VIROLOGY
- The lack of protective immunity against RSV in the elderly
- (2009) O. SCHILDGEN EPIDEMIOLOGY AND INFECTION
- Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in mice
- (2009) C. Miao et al. JOURNAL OF GENERAL VIROLOGY
- Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients
- (2009) E. J. Collarini et al. JOURNAL OF IMMUNOLOGY
- Therapeutic Monoclonal Antibody Treatment Targeting Respiratory Syncytial Virus (RSV) G Protein Mediates Viral Clearance and Reduces the Pathogenesis of RSV Infection in BALB/c Mice
- (2009) Lia M. Haynes et al. JOURNAL OF INFECTIOUS DISEASES
- Human Respiratory Syncytial Virus Nonstructural Protein NS2 Antagonizes the Activation of Beta Interferon Transcription by Interacting with RIG-I
- (2009) Z. Ling et al. JOURNAL OF VIROLOGY
- Respiratory Syncytial Virus Grown in Vero Cells Contains a Truncated Attachment Protein That Alters Its Infectivity and Dependence on Glycosaminoglycans
- (2009) S. Kwilas et al. JOURNAL OF VIROLOGY
- Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
- (2008) J DEVINCENZO et al. ANTIVIRAL RESEARCH
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