Challenges and Opportunities in Developing Respiratory Syncytial Virus Therapeutics

Nosocomial Transmission of Respiratory Syncytial Virus in an Outpatient Cancer Center

(2014) Helen Y. Chu et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections

(2014) D. P. Shah et al.   BLOOD

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

(2014) Javier Díez-Domingo et al.   BMC INFECTIOUS DISEASES

RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction

(2014) Rachael M. Liesman et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral GS-5806 Activity in a Respiratory Syncytial Virus Challenge Study

(2014) John P. DeVincenzo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors for Life-Threatening Lower Respiratory Tract Infections in Children: A Retrospective Study in an Urban City in Malaysia

(2014) Anna Marie Nathan et al.   PLoS One

Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

(2014) Stella G Muthuri et al.   Lancet Respiratory Medicine

Development of a high-throughput replicon assay for the identification of respiratory syncytial virus inhibitors

(2013) Choi-Lai Tiong-Yip et al.   ANTIVIRAL RESEARCH

Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals

(2013) Bindiya Bagga et al.   ANTIVIRAL THERAPY

Mortality Rates of Human Metapneumovirus and Respiratory Syncytial Virus Lower Respiratory Tract Infections in Hematopoietic Cell Transplantation Recipients

(2013) Christian Renaud et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis

(2013) A. G. Randolph et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Respiratory Syncytial Virus Lower Respiratory Disease in Hematopoietic Cell Transplant Recipients: Viral RNA Detection in Blood, Antiviral Treatment, and Clinical Outcomes

(2013) Alpana Waghmare et al.   CLINICAL INFECTIOUS DISEASES

High Morbidity and Mortality in Adults Hospitalized for Respiratory Syncytial Virus Infections

(2013) N. Lee et al.   CLINICAL INFECTIOUS DISEASES

Molecular Detection of Respiratory Viruses

(2013) Richard S. Buller   CLINICS IN LABORATORY MEDICINE

The role of early life viral bronchiolitis in the inception of asthma

(2013) Avraham Beigelman et al.   Current Opinion in Allergy and Clinical Immunology

Addressing the public health burden of respiratory viruses: the Battle against Respiratory Viruses (BRaVe) Initiative

(2013) Anaïs Legand et al.   Future Virology

Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections

(2013) D. P. Shah et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Development of a Sensitive Loop-Mediated Isothermal Amplification Assay That Provides Specimen-to-Result Diagnosis of Respiratory Syncytial Virus Infection in 30 Minutes

(2013) J. Mahony et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Bacterial Complications of Respiratory Tract Viral Illness: A Comprehensive Evaluation

(2013) A. R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

Respiratory Syncytial Virus in Hematopoietic Cell Transplant Recipients: Factors Determining Progression to Lower Respiratory Tract Disease

(2013) Yae-Jean Kim et al.   JOURNAL OF INFECTIOUS DISEASES

Viral Shedding and Immune Responses to Respiratory Syncytial Virus Infection in Older Adults

(2013) Edward E. Walsh et al.   JOURNAL OF INFECTIOUS DISEASES

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

(2013) Kevin Fitzgerald et al.   LANCET

Respiratory Syncytial Virus and Recurrent Wheeze in Healthy Preterm Infants

(2013) Maarten O. Blanken et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lack of Long-term Effects of High-dose Inhaled Beclomethasone for Respiratory Syncytial Virus Bronchiolitis

(2013) Kim Zomer-Kooijker et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Motavizumab Treatment of Infants Hospitalized With Respiratory Syncytial Virus Infection Does Not Decrease Viral Load or Severity of Illness

(2013) Octavio Ramilo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Effect of Palivizumab Prophylaxis on Subsequent Recurrent Wheezing in Preterm Infants

(2013) S. Yoshihara et al.   PEDIATRICS

Architecture of respiratory syncytial virus revealed by electron cryotomography

(2013) L. Liljeroos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

RSV Fusion: Time for a New Model

(2013) Peter Mastrangelo et al.   Viruses-Basel

Antibodies for prevention and treatment of respiratory syncytial virus infections in children

(2012) Bessey Geevarghese et al.   ANTIVIRAL THERAPY

Hospitalizations Associated With Influenza and Respiratory Syncytial Virus in the United States, 1993–2008

(2012) Hong Zhou et al.   CLINICAL INFECTIOUS DISEASES

Aetiology of community-acquired pneumonia among adults in an H1N1 pandemic year: the role of respiratory viruses

(2012) A. Sangil et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Rates of Hospitalizations for Respiratory Syncytial Virus, Human Metapneumovirus, and Influenza Virus in Older Adults

(2012) Kyle Widmer et al.   JOURNAL OF INFECTIOUS DISEASES

Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons

(2012) Liselotte van Asten et al.   JOURNAL OF INFECTIOUS DISEASES

Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus

(2012) Carolina Scagnolari et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

IL1RL1 Gene Variants and Nasopharyngeal IL1RL-a Levels Are Associated with Severe RSV Bronchiolitis: A Multicenter Cohort Study

(2012) Tina E. Faber et al.   PLoS One

Etiology and Incidence of Viral and Bacterial Acute Respiratory Illness among Older Children and Adults in Rural Western Kenya, 2007–2010

(2012) Daniel R. Feikin et al.   PLoS One

Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study

(2012) J. Puig-Barberà et al.   VACCINE

Animal models of human respiratory syncytial virus disease

(2011) Reinout A. Bem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Respiratory Syncytial Virus Binds and Undergoes Transcription in Neutrophils From the Blood and Airways of Infants With Severe Bronchiolitis

(2011) Clare P. Halfhide et al.   JOURNAL OF INFECTIOUS DISEASES

Respiratory Syncytial Virus Load, Viral Dynamics, and Disease Severity in Previously Healthy Naturally Infected Children

(2011) Chadi M. El Saleeby et al.   JOURNAL OF INFECTIOUS DISEASES

Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African Children

(2011) T.L. Kresfelder et al.   JOURNAL OF MEDICAL VIROLOGY

A Lean Laboratory

(2011) Nicola E. Dundas et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Identification of nucleolin as a cellular receptor for human respiratory syncytial virus

(2011) Farnoosh Tayyari et al.   NATURE MEDICINE

The Epidemiology of Respiratory Syncytial Virus Lower Respiratory Tract Infections in Children Less than 5 Years of Age in Indonesia

(2011) Eric A. F. Simões et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Commentary: Why Are Young Healthy Term Infants Protected Against Respiratory Syncytial Virus Bronchiolitis?

(2011) Louis Bont et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication

(2011) Michael E. Lindquist et al.   VIROLOGY

Viral Load Drives Disease in Humans Experimentally Infected with Respiratory Syncytial Virus

(2010) John P. DeVincenzo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Management of RSV infections in adult recipients of hematopoietic stem cell transplantation

(2010) J. N. Shah et al.   BLOOD

Early Oseltamivir Treatment of Influenza in Children 1–3 Years of Age: A Randomized Controlled Trial

(2010) Santtu Heinonen et al.   CLINICAL INFECTIOUS DISEASES

The use of a neonatal mouse model to study respiratory syncytial virus infections

(2010) Stephania A Cormier et al.   Expert Review of Anti-Infective Therapy

The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children

(2010) Eric A.F. Simões et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection

(2010) Anna Franz et al.   JOURNAL OF CLINICAL VIROLOGY

Pandemic influenza A(H1N1) 2009 and respiratory syncytial virus associated hospitalizations

(2010) Fernando Lovato-Salas et al.   JOURNAL OF INFECTION

Respiratory Virus Pneumonia after Hematopoietic Cell Transplantation (HCT): Associations between Viral Load in Bronchoalveolar Lavage Samples, Viral RNA Detection in Serum Samples, and Clinical Outcomes of HCT

(2010) Angela P. Campbell et al.   JOURNAL OF INFECTIOUS DISEASES

Disease severity and viral load are correlated in infants with primary respiratory syncytial virus infection in the community

(2010) M.L. Houben et al.   JOURNAL OF MEDICAL VIROLOGY

Respiratory Syncytial Virus Induces Host RNA Stress Granules To Facilitate Viral Replication

(2010) M. E. Lindquist et al.   JOURNAL OF VIROLOGY

Prophylactic Treatment with a G Glycoprotein Monoclonal Antibody Reduces Pulmonary Inflammation in Respiratory Syncytial Virus (RSV)-Challenged Naive and Formalin-Inactivated RSV-Immunized BALB/c Mice

(2010) G. U. Radu et al.   JOURNAL OF VIROLOGY

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

The Relationship Between Respiratory Viral Loads and Diagnosis in Children Presenting to a Pediatric Hospital Emergency Department

(2010) Soraya Utokaparch et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Clinical Prediction Rule for RSV Bronchiolitis in Healthy Newborns: Prognostic Birth Cohort Study

(2010) M. L. Houben et al.   PEDIATRICS

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life

(2010) N. Sigurs et al.   THORAX

Causal Links between RSV Infection and Asthma

(2009) Claudia E. Kuehni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Developments in Immunologic Assays for Respiratory Viruses

(2009) Marie Louise Landry   CLINICS IN LABORATORY MEDICINE

Antigen-Based Assays for the Identification of Influenza Virus and Respiratory Syncytial Virus: Why and How to Use Them in Pediatric Practice

(2009) Nicola Principi et al.   CLINICS IN LABORATORY MEDICINE

Risk Factors for Respiratory Failure Associated with Respiratory Syncytial Virus Infection in Adults

(2009) Coley B. Duncan et al.   JOURNAL OF INFECTIOUS DISEASES

A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants

(2009) M. V. Lukens et al.   JOURNAL OF VIROLOGY

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

(2009) Mark J Kwakkenbos et al.   NATURE MEDICINE

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

SAFETY AND ANTIVIRAL ACTIVITY OF MOTAVIZUMAB, A RESPIRATORY SYNCYTIAL VIRUS (RSV)–SPECIFIC HUMANIZED MONOCLONAL ANTIBODY, WHEN ADMINISTERED TO RSV-INFECTED CHILDREN

(2009) Rosanna Lagos et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

QUANTITATION OF RESPIRATORY VIRUSES IN RELATION TO CLINICAL COURSE IN CHILDREN WITH ACUTE RESPIRATORY TRACT INFECTIONS

(2009) Rogier R. Jansen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Motavizumab for Prophylaxis of Respiratory Syncytial Virus in High-Risk Children: A Noninferiority Trial

(2009) X. Carbonell-Estrany et al.   PEDIATRICS

Surface features of a Mononegavirales matrix protein indicate sites of membrane interaction

(2009) V. A. Money et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil TLR4 expression is reduced in the airways of infants with severe bronchiolitis

(2009) C P Halfhide et al.   THORAX

Community-Acquired Respiratory Viral Infections in Lung Transplant Recipients: A Single Season Cohort Study

(2009) Jens Gottlieb et al.   TRANSPLANTATION

Human Metapneumovirus in Lung Transplant Recipients and Comparison to Respiratory Syncytial Virus

(2008) Peter Hopkins et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Genetic Factors and Respiratory Syncytial Virus Disease Severity

(2008) I. Miyairi et al.   CLINICAL MICROBIOLOGY REVIEWS

Detection of Respiratory Viruses by Molecular Methods

(2008) J. B. Mahony   CLINICAL MICROBIOLOGY REVIEWS

Long-Term Care Facilities: A Cornucopia of Viral Pathogens

(2008) Ann R. Falsey et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Introduction

(2008) John P. DeVincenzo et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Seasonal Invasive Pneumococcal Disease in Children: Role of Preceding Respiratory Viral Infection

(2008) K. Ampofo et al.   PEDIATRICS

Increased Concordance of Severe Respiratory Syncytial Virus Infection in Identical Twins

(2008) S. F. Thomsen et al.   PEDIATRICS

Risk Factors for Severe Respiratory Syncytial Virus Disease in Children With Cancer: The Importance of Lymphopenia and Young Age

(2008) C. M. El Saleeby et al.   PEDIATRICS

Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2

(2008) T. J. Utley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory Syncytial Virus Infection and Disease in Infants and Young Children Observed from Birth in Kilifi District, Kenya

(2007) D. J. Nokes et al.   CLINICAL INFECTIOUS DISEASES

Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy

(2007) G. Gerna et al.   JOURNAL OF CLINICAL VIROLOGY