Cellular fatty acid synthase is required for late stages of HIV-1 replication

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

(2016) Matthew K. Howe et al.   ANTIVIRAL RESEARCH

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

(2015) Shuhei Taguwa et al.   CELL

Phosphatidylinositol-(4,5)-Bisphosphate Acyl Chains Differentiate Membrane Binding of HIV-1 Gag from That of the Phospholipase Cδ1 Pleckstrin Homology Domain

(2015) Balaji Olety et al.   JOURNAL OF VIROLOGY

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo

(2014) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

(2014) Matthew D. Greseth et al.   PLoS Pathogens

Host-targeting agents in the treatment of hepatitis C: A beginning and an end?

(2013) James M. Baugh et al.   ANTIVIRAL RESEARCH

HIV-1 Gag Associates with Specific Uropod-Directed Microdomains in a Manner Dependent on Its MA Highly Basic Region

(2013) G. N. Llewellyn et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Replication Is Modulated by the Interaction of Nonstructural Protein NS5B and Fatty Acid Synthase

(2013) J.-T. Huang et al.   JOURNAL OF VIROLOGY

Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

(2013) Yukie Yoshii et al.   PLoS One

HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes

(2012) R. A. Dick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperthermia Stimulates HIV-1 Replication

(2012) Ferdinand Roesch et al.   PLoS Pathogens

Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication

(2011) Steffi Wilsky et al.   ARCHIVES OF VIROLOGY

The Genetic Bottleneck in Vertical Transmission of Subtype C HIV-1 Is Not Driven by Selection of Especially Neutralization-Resistant Virus from the Maternal Viral Population

(2011) E. S. Russell et al.   JOURNAL OF VIROLOGY

Uncovering the global host cell requirements for influenza virus replication via RNAi screening

(2011) Silke Stertz et al.   MICROBES AND INFECTION

West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids

(2011) Miguel A. Martín-Acebes et al.   PLoS One

Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection

(2010) Gerard Aragonès et al.   BMC GASTROENTEROLOGY

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

(2010) Patrick Fadden et al.   CHEMISTRY & BIOLOGY

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

(2010) Luciano Vozzolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis

(2010) Jochen G. Schneider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Discovery of insect and human dengue virus host factors

(2009) October M. Sessions et al.   NATURE

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Knockdown Screens to Knockout HIV-1

(2008) Stephen P. Goff   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

(2008) Wei Yang et al.   HEPATOLOGY

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY

HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study

(2008) Suraiya Rasheed et al.   PLoS One

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE