Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence

Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure

(2019) Ciro Milite et al.   JOURNAL OF MEDICINAL CHEMISTRY

P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy

(2019) Fuzhe Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent advances in inhibitors of sirtuin1/2: an update and perspective

(2018) Ziyan Zhou et al.   Future Medicinal Chemistry

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

(2018) Hao Wu et al.   JOURNAL OF ENDOCRINOLOGY

MicroRNA-34a targets sirtuin 1 and leads to diabetes-induced testicular apoptotic cell death

(2018) Dan Jiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Sirt1 activator, SRT1720, attenuates renal fibrosis by inhibiting CTGF and oxidative stress

(2017) Yunzhuo Ren et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

(2017) Matthias Schiedel et al.   MEDICINAL RESEARCH REVIEWS

How much successful are the medicinal chemists in modulation of SIRT1: A critical review

(2016) Ashwani Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

(2016) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

(2016) Brenda Rascón et al.   Aging-US

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

(2015) Duanfang Cao et al.   GENES & DEVELOPMENT

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

Why is Tanimoto index an appropriate choice for fingerprint-based similarity calculations?

(2015) Dávid Bajusz et al.   Journal of Cheminformatics

SIRTain regulators of premature senescence and accelerated aging

(2015) Shrestha Ghosh et al.   Protein & Cell

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

(2014) Marianne R. Smith et al.   HUMAN MOLECULAR GENETICS

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

Target–drug interactions: first principles and their application to drug discovery

(2011) Sara Núñez et al.   DRUG DISCOVERY TODAY

Sirtuins

(2010) Anthony A. Sauve   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators

(2009) Chi B. Vu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

(2008) Jean E. Bemis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON