MEX3A regulates Lgr5 + stem cell maintenance in the developing intestinal epithelium

Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

(2019) David Castillo‐Azofeifa et al.   EMBO JOURNAL

Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth

(2019) Olga N. Karpus et al.   Cell Reports

Tracing the origin of adult intestinal stem cells

(2019) Jordi Guiu et al.   NATURE

Paneth Cell Multipotency Induced by Notch Activation following Injury

(2018) Shiyan Yu et al.   Cell Stem Cell

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

(2018) Lu Huang et al.   CLINICAL CANCER RESEARCH

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium

(2018) Fumiaki Ishibashi et al.   Stem Cell Reports

Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration

(2018) Goran Tomic et al.   Cell Stem Cell

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells

(2018) Bahar Degirmenci et al.   NATURE

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

(2018) Mark Schmitt et al.   Cell Reports

Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning

(2018) Marit Navis et al.   EMBO REPORTS

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity

(2017) Hirotsugu Yanai et al.   Scientific Reports

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

(2016) Paul W. Tetteh et al.   Cell Stem Cell

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation

(2016) Yusuke Yamazumi et al.   Cell Reports

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness

(2015) F.M. Cambuli et al.   STEM CELLS

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

(2015) Stacy R. Finkbeiner et al.   Stem Cell Reports

Regulation of Pluripotency by RNA Binding Proteins

(2014) Julia Ye et al.   Cell Stem Cell

The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway

(2014) M. Le Borgne et al.   DEVELOPMENT

INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

(2014)   NUCLEIC ACIDS RESEARCH

Mucolipin Co-deficiency Causes Accelerated Endolysosomal Vacuolation of Enterocytes and Failure-to-Thrive from Birth to Weaning

(2014) Natalie N. Remis et al.   PLoS Genetics

Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus

(2014) Jurian Schuijers et al.   Stem Cell Reports

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness

(2013) Bruno Pereira et al.   NUCLEIC ACIDS RESEARCH

MEX-3 proteins: recent insights on novel post-transcriptional regulators

(2013) Bruno Pereira et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Optimality in the Development of Intestinal Crypts

(2012) Shalev Itzkovitz et al.   CELL

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

(2012) Florencia Cano et al.   EMBO JOURNAL

Mex3c Mutation Reduces Adiposity and Increases Energy Expenditure

(2012) Y. Jiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

(2012) T.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARGEpigenetic Deregulation and Its Role in Colorectal Tumorigenesis

(2012) Lina Sabatino et al.   PPAR Research

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Expansion of Intestinal Epithelial Stem Cells during Murine Development

(2011) Jeffrey J. Dehmer et al.   PLoS One

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

(2011) N. Takeda et al.   SCIENCE

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

(2010) R. K. Montgomery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Transcriptional activation of Cidec by PPARγ2 in adipocyte

(2008) Yoon-Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS