Article
Endocrinology & Metabolism
Johanna Y. Fleischman, Nathan R. Qi, Mary K. Treutelaar, Steven L. Britton, Lauren G. Koch, Jun Z. Li, Charles F. Burant
Summary: Caloric restriction improves metabolic health and shares similarities with high cardiorespiratory fitness in terms of adiposity reduction, enhanced cardiometabolic health, and increased longevity. This study investigates whether the mechanisms through which heritable high cardiorespiratory fitness occurs are similar to those promoting health and longevity through caloric restriction. The results suggest that caloric restriction has positive effects on physiological parameters in low cardiorespiratory fitness rats that resemble those seen in high cardiorespiratory fitness rats.
MOLECULAR METABOLISM
(2023)
Review
Oncology
Erwan Eriau, Juliette Paillet, Guido Kroemer, Jonathan G. Pol
Summary: Reduced food intake and caloric restriction mimetics have been shown to increase healthy lifespan, reduce cancer incidence, and enhance responses to certain cancer treatments. These effects are mediated by cellular mechanisms and vary between cancer cells and healthy cells due to differences in metabolic requirements. Additionally, both reduced food intake and caloric restriction mimetics can induce autophagy, improving the efficacy of certain cancer treatments that induce immunogenic cell death and enhance the therapeutic efficacy of chemo-immunotherapies.
Article
Multidisciplinary Sciences
Volha Mezhnina, Oghogho P. Ebeigbe, Nikkhil Velingkaar, Allan Poe, Yana Sandlers, Roman V. Kondratov
Summary: The study reveals that caloric restriction and time-restricted feeding can induce rhythmic production of ketone bodies in the blood, which is regulated by PPARα and FGF21 and involves the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Ezzeldin M. Ibrahim, Meteb H. Al-Foheidi, Mubarak M. Al-Mansour
Summary: Dietary interventions have a significant impact on body metabolism and can hinder cancer growth and progression while enhancing the efficacy of chemotherapy and radiation therapy. Although current clinical trials have small sample sizes, they have shown clinical benefits for cancer patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nutrition & Dietetics
Chanisa Thonusin, Patcharapong Pantiya, Aphisek Kongkaew, Wichwara Nawara, Busarin Arunsak, Sirawit Sriwichaiin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Exercise and caloric restriction have different effects on skeletal muscle metabolism during aging. Exercise is more effective in improving fatty acid oxidation and oxidative phosphorylation, while caloric restriction reduces oxidative stress in skeletal muscle.
Article
Food Science & Technology
Mustafa Fevzi Karagoz, A. Gulcin Sagdicoglu Celep
Summary: Energy restriction, a non-genetic intervention, increases life expectancy by stimulating NAD+ and AMP levels, activating SIRT enzymes and AMPK. These enzymes regulate various mechanisms, including enhancing resistance to oxidative stress, inducing apoptosis, and suppressing tumor growth. Energy restriction also stimulates autophagy, mitophagy, and mitochondrial biogenesis, while regulating lipid metabolism and inflammatory response through genetic pathways.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Multidisciplinary Sciences
Tong-Hong Wang, Wei-Che Tseng, Yann-Lii Leu, Chi-Yuan Chen, Wen-Chih Lee, Ying-Chih Chi, Shu-Fang Cheng, Chun-Yu Lai, Chen-Hsin Kuo, Shu-Ling Yang, Sien-Hung Yang, Jiann-Jong Shen, Chun-Hao Feng, Chih-Ching Wu, Tsong-Long Hwang, Chia-Jen Wang, Shu-Huei Wang, Chin-Chuan Chen
Summary: The flavonoid corylin, isolated from Psoralea corylifolia, has been found to exhibit longevity properties in yeast, human cells, and mice. Traditional Chinese medicine has long been believed to increase lifespan, but identifying the specific molecules responsible for this effect has been challenging. Through screening traditional Chinese medicines and isolating compounds, researchers identified corylin as a key molecule in Psoralea corylifolia that extends lifespan in various organisms.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Chaise Murphy, Laura D. Bilek, Karsten Koehler
Summary: The study suggests that low energy availability (LEA) may negatively impact bone health, with high-protein diets not attenuating these effects. LEA appears to shift bone turnover in favor of bone resorption.
Article
Biology
Bernd Niemann, Ruping Pan, Hassan Issa, Andreas Simm, Rainer Schulz, Susanne Rohrbach
Summary: This study investigated the impact of caloric restriction on heart failure progression and found that caloric restriction inhibits the loss of heart function, even in established heart failure. These findings deepen our understanding of the mechanisms behind the cardioprotective effects of caloric restriction.
Article
Neurosciences
Matine Azadian, Guilian Tian, Afsheen Bazrafkan, Niki Maki, Masih Rafi, Nikole Chetty, Monica Desai, Ieeshiah Otarola, Francisco Aguirre, Shuhab M. Zaher, Ashar Khan, Yusuf Suri, Minwei Wang, Beth A. Lopour, Oswald Steward, Yama Akbari
Summary: It has been shown that overnight caloric restriction improves survival and neurological recovery in acute ischemic brain injury models, by normalizing stress-induced hyperglycemia and affecting hormone production. These benefits appear unrelated to SIRT-1 and BDNF expression, with mechanisms still needing further clarification.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Immunology
Lukai Zhai, Connie M. Krawczyk
Summary: The reduction of SPARC during caloric restriction (CR) is found to offer beneficial effects by reducing SPARC-driven inflammatory phenotypes in macrophages.
Article
Biochemistry & Molecular Biology
Artem P. Gureev, Nadezda V. Andrianova, Irina B. Pevzner, Ljubava D. Zorova, Ekaterina V. Chernyshova, Irina S. Sadovnikova, Dmitry V. Chistyakov, Vasily A. Popkov, Dmitry S. Semenovich, Valentina A. Babenko, Denis N. Silachev, Dmitry B. Zorov, Egor Y. Plotnikov, Vasily N. Popov
Summary: This study found that in aging rats, mtDNA in the brain and kidneys was the most susceptible to age-related damage, while the liver, testis, and lungs were the least affected. Dietary restriction (DR) can prevent the accumulation of mtDNA damage in the cortex and reduce it in the lungs and testes.
Review
Endocrinology & Metabolism
Jiayi Sun, Xin Shen, Hui Liu, Siying Lu, Jing Peng, Haibin Kuang
Summary: Caloric restriction (CR) is an intervention that affects female reproduction by regulating the hypothalamic and peripheral mediators, impacting fertility while preserving reproductive capacity. Understanding the comprehensive effects of CR on the central and peripheral systems, as well as its relationship with reproductive-associated diseases, can provide better strategies for managing and preventing female reproductive dysfunctions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Khadidja Kessas, Zhor Chouari, Imen Ghzaiel, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Adil El Midaoui, Gerard Lizard, Omar Kharoubi
Summary: This article discusses the role of mitochondria in metabolic processes and their relationship with oxidative stress, neurodegenerative diseases, and apoptosis. The study reveals the potential neuroprotective effects of bioactive compounds and the development of mitochondrial-targeted drugs to alleviate neurodegenerative diseases and promote healthy aging.
Article
Multidisciplinary Sciences
Zhao Liu, Mengjie Liu, Gongwei Jia, Jiani Li, Lingchuan Niu, Huiji Zhang, Yunwen Qi, Houchao Sun, Liang-Jun Yan, Jingxi Ma
Summary: Intermittent fasting (IF) is a form of time restricted eating with potential neuroprotective effects. This study investigated the effect of IF on cerebral angiogenesis in ischemic rats. The results showed that long-term IF improved neurological outcomes, increased microvessel density (MVD), and activated the GDF11/ALK5 signaling pathway.
Article
Neurosciences
Carlos B. Rueda, Javier Traba, Ignacio Amigo, Irene Llorente-Folch, Paloma Gonzalez-Sanchez, Beatriz Pardo, Jose A. Esteban, Araceli del Arco, Jorgina Satrustegui
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Carlos B. Rueda, Irene Llorente-Folch, Ignacio Amigo, Laura Contreras, Paloma Gonzalez-Sanchez, Paula Martinez-Valero, Ines Juaristi, Beatriz Pardo, Araceli del Arco, Jorgina Satrustegui
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2014)
Article
Biochemistry & Molecular Biology
Ignacio Amigo, Javier Traba, M. Mar Gonzalez-Barroso, Carlos B. Rueda, Margarita Fernandez, Eduardo Rial, Aranzazu Sanchez, Jorgina Satrustegui, Araceli del Arco
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Neurosciences
Irene Llorente-Folch, Carlos B. Rueda, Ignacio Amigo, Araceli del Arco, Takeyori Saheki, Beatriz Pardo, Jorgina Satrustegui
JOURNAL OF NEUROSCIENCE
(2013)
Article
Multidisciplinary Sciences
Ignacio Amigo, Javier Traba, Jorgina Satrustegui, Araceli del Arco
