Neuronal control of peripheral nutrient partitioning

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment

(2019) Peter Kühnen et al.   TRENDS IN MOLECULAR MEDICINE

Regulation of substrate utilization and adiposity by Agrp neurons

(2019) João Paulo Cavalcanti-de-Albuquerque et al.   Nature Communications

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

(2019) Anne E. Justice et al.   NATURE GENETICS

A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake

(2019) Jenna Holland et al.   Cell Reports

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

(2019) Martina Theresa Hackl et al.   Nature Communications

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

(2018) Alex Reichenbach et al.   FASEB JOURNAL

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

(2018) Rebecca J. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

Signalling from the periphery to the brain that regulates energy homeostasis

(2018) Ki-Suk Kim et al.   NATURE REVIEWS NEUROSCIENCE

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

(2018) Alex Reichenbach et al.   Cell Reports

Genetic identification of leptin neural circuits in energy and glucose homeostases

(2018) Jie Xu et al.   NATURE

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

(2018) Claus Brandt et al.   CELL

Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin

(2018) Jeffrey S Flier   ENDOCRINE REVIEWS

Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition

(2017) Kevin D. Hall et al.   GASTROENTEROLOGY

Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression

(2017) Cristina Mora et al.   JOURNAL OF ENDOCRINOLOGY

Convergence between biological, behavioural and genetic determinants of obesity

(2017) Sujoy Ghosh et al.   NATURE REVIEWS GENETICS

The Role of the Autonomic Nervous System in the Pathophysiology of Obesity

(2017) Daniela Guarino et al.   Frontiers in Physiology

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

(2016) Alexandre Caron et al.   Annals of the New York Academy of Sciences

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Effects of γ-Aminobutyric Acid A Receptor Activation on Counterregulatory Responses to Subsequent Exercise in Individuals With Type 1 Diabetes

(2016) Maka S. Hedrington et al.   DIABETES

Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy

(2016) Ursula H. Neumann et al.   ENDOCRINOLOGY

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

(2016) Jarrad M Scarlett et al.   NATURE MEDICINE

Melanocortin-4 receptor–regulated energy homeostasis

(2016) Michael J Krashes et al.   NATURE NEUROSCIENCE

Functional identification of a neurocircuit regulating blood glucose

(2016) Thomas H. Meek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

(2015) Sarah E. Seiler et al.   Cell Metabolism

RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals

(2015) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypothalamic carnitine metabolism integrates nutrient and hormonal feedback to regulate energy homeostasis

(2015) Romana Stark et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

(2014) Hai-Bin Ruan et al.   CELL

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Inhibition of the central melanocortin system decreases brown adipose tissue activity

(2014) Sander Kooijman et al.   JOURNAL OF LIPID RESEARCH

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

Hypothalamic Agouti-Related Peptide Neurons and the Central Melanocortin System Are Crucial Mediators of Leptin’s Antidiabetic Actions

(2014) Gabriel H.M. Gonçalves et al.   Cell Reports

Neural pathways that control the glucose counterregulatory response

(2014) Anthony J. M. Verberne et al.   Frontiers in Neuroscience

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose

(2013) Melissa A. Burmeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin

(2013) Teppei Fujikawa et al.   Cell Metabolism

Glucose Regulates Hypothalamic Long-chain Fatty Acid Metabolism via AMP-activated Kinase (AMPK) in Neurons and Astrocytes

(2013) Bouchra Taïb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

(2013) Geneviève Marcelin et al.   Molecular Metabolism

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

(2012) Aurélie Joly-Amado et al.   EMBO JOURNAL

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent

(2012) Darleen Sandoval et al.   PLoS One

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Effects of Antecedent GABAA Activation With Alprazolam on Counterregulatory Responses to Hypoglycemia in Healthy Humans

(2010) M. S. Hedrington et al.   DIABETES

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

(2010) F. K. Huynh et al.   DIABETES

Melanocortin signaling in the CNS directly regulates circulating cholesterol

(2010) Diego Perez-Tilve et al.   NATURE NEUROSCIENCE

A Functional Melanocortin System May Be Required for Chronic CNS-Mediated Antidiabetic and Cardiovascular Actions of Leptin

(2009) A. A. da Silva et al.   DIABETES

Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin

(2008) Miguel López et al.   Cell Metabolism

Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia

(2008) O. Chan et al.   DIABETES

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE