Selenium and selenoproteins in prostanoid metabolism and immunity

Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R

(2019) Xue-Lian Meng et al.   NEUROSCIENCE

Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers

(2019) Jan Bilski et al.   Nutrients

Interaction of tumor-associated macrophages and cancer chemotherapy

(2019) Irina Larionova et al.   OncoImmunology

Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer

(2019) Michael P. Marciel et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium

(2019) Bastihalli T. Diwakar et al.   FASEB JOURNAL

Tolerance to selenoprotein loss differs between human and mouse

(2019) Didac Santesmasses et al.   MOLECULAR BIOLOGY AND EVOLUTION

Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms

(2019) Solveigh C. Koeberle et al.   Redox Biology

Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis

(2018) Chang Liao et al.   BLOOD

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

The intricate role of selenium and selenoproteins in erythropoiesis

(2018) Chang Liao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

(2018) Sun Hee Yim et al.   Cell Reports

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

(2018) Cong Li et al.   Frontiers in Pharmacology

IL-4 up-regulates cyclooxygenase-1 expression in macrophages

(2017) Ashley E. Shay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cadmium-induced endoplasmic reticulum stress in chicken neutrophils is alleviated by selenium

(2017) Jianqiao Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Oral administration of synthetic selenium nanoparticles induced robust Th1 cytokine pattern after HBs antigen vaccination in mouse model

(2017) Mehdi Mahdavi et al.   Journal of Infection and Public Health

Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo

(2017) Byung Cheon Lee et al.   Scientific Reports

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

(2016) Kazunori Hashimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1–Deficient Hyperlipidemic MiceClinical Perspective

(2016) Soon Yew Tang et al.   CIRCULATION

Anti-tumor and immunomodulatory activity of selenium (Se)-polysaccharide from Se-enriched Grifola frondosa

(2016) Guang-Hua Mao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient FcγR-mediated phagocytosis

(2016) Robert L. Norton et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Suppression of immune regulatory cells with combined therapy of celecoxib and sunitinib in renal cell carcinoma

(2016) Qi Zhao et al.   Oncotarget

Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy

(2016) Chen-Hsueh Pai et al.   PLoS One

Prostaglandins E2 signal mediated by receptor subtype EP2 promotes IgE production in vivo and contributes to asthma development

(2016) Yuhan Gao et al.   Scientific Reports

Selenium and inflammatory bowel disease

(2015) Avinash K. Kudva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Treprostinil Iontophoresis in Idiopathic Pulmonary Arterial Hypertension

(2015) Adriano R. Tonelli et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks

(2015) Jiu-li Zhang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Activation of the Prostaglandin E2 receptor EP2 prevents house dust mite-induced airway hyperresponsiveness and inflammation by restraining mast cells’ activity

(2015) M. Serra-Pages et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic HelminthNippostrongylus brasiliensis

(2015) Shakira M. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic phospholipase A2: physiological function and role in disease

(2015) Christina C. Leslie   JOURNAL OF LIPID RESEARCH

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

(2015) Vivek Narayan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prostacyclin protects vascular integrity via PPAR/14-3-3 pathway

(2015) Ling-yun Chu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Th1 Immune Response Induction by Biogenic Selenium Nanoparticles in Mice with Breast Cancer: Preliminary Vaccine Model

(2015) Mohammad Hossein Yazdi et al.   Iranian Journal of Biotechnology

Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity

(2015) Yongkui Li et al.   OncoImmunology

Selenoprotein S is involved in maintenance and transport of multiprotein complexes

(2014) Anton A. Turanov et al.   BIOCHEMICAL JOURNAL

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPx2 Suppression of H2O2 Stress Links the Formation of Differentiated Tumor Mass to Metastatic Capacity in Colorectal Cancer

(2014) B. L. Emmink et al.   CANCER RESEARCH

Selenium Suppresses Leukemia through the Action of Endogenous Eicosanoids

(2014) U. H. Gandhi et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alternatively Activated Myeloid Cells Limit Pathogenicity Associated with African Trypanosomiasis through the IL-10 Inducible Gene Selenoprotein P

(2014) Tom Bosschaerts et al.   JOURNAL OF IMMUNOLOGY

Crucial Role of Macrophage Selenoproteins in Experimental Colitis

(2014) Naveen Kaushal et al.   JOURNAL OF IMMUNOLOGY

Opposing Roles of Prostaglandin D2Receptors in Ulcerative Colitis

(2014) Eva M. Sturm et al.   JOURNAL OF IMMUNOLOGY

Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex

(2014) Gregory J. Fredericks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver Kinase B1 Is Required for Thromboxane Receptor-Dependent Nuclear Factor-κB Activation and Inflammatory Responses

(2013) Jinlong He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts

(2013) X Wang et al.   BRITISH JOURNAL OF CANCER

Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana

(2013) Marianna K. Baum et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Targeted Disruption of Glutathione Peroxidase 4 in Mouse Skin Epithelial Cells Impairs Postnatal Hair Follicle Morphogenesis that Is Partially Rescued through Inhibition of COX-2

(2013) Aniruddha Sengupta et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

MsrB1 and MICALs Regulate Actin Assembly and Macrophage Function via Reversible Stereoselective Methionine Oxidation

(2013) Byung Cheon Lee et al.   MOLECULAR CELL

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

Deletion of Glutathione Peroxidase-2 Inhibits Azoxymethane-Induced Colon Cancer Development

(2013) Mike F. Müller et al.   PLoS One

Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

(2013) Mário Henrique M. Barros et al.   PLoS One

Selenium Supplementation Restores Innate and Humoral Immune Responses in Footrot-Affected Sheep

(2013) Jean A. Hall et al.   PLoS One

Increased levels of IL-6, IL-1β, and TNF-α in Kashin–Beck disease and rats induced by T-2 toxin and selenium deficiency

(2013) Xiaorong Zhou et al.   RHEUMATOLOGY INTERNATIONAL

IL-1β/HMGB1 Complexes Promote The PGE2Biosynthesis Pathway in Synovial Fibroblasts

(2013) P. Leclerc et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis

(2012) Regina Brigelius-Flohé et al.   Annals of the New York Academy of Sciences

The Immunostimulatory Effect of Biogenic Selenium Nanoparticles on the 4T1 Breast Cancer Model: an In Vivo Study

(2012) Mohammad Hossein Yazdi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Tumor Suppressor Function of the Plasma Glutathione Peroxidase Gpx3 in Colitis-Associated Carcinoma

(2012) C. W. Barrett et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Selenium Promotes T-Cell Response to TCR-Stimulation and ConA, but Not PHA in Primary Porcine Splenocytes

(2012) Fei Ren et al.   PLoS One

Self-Limited versus Delayed Resolution of Acute Inflammation: Temporal Regulation of Pro-Resolving Mediators and MicroRNA

(2012) Gabrielle Fredman et al.   Scientific Reports

The immune microenvironment as a guide for cancer therapies

(2012) Wolf H. Fridman   OncoImmunology

Effect of Dietary Selenium and Cancer Cell Xenograft on Peripheral T and B Lymphocytes in Adult Nude Mice

(2011) Wen-Hsing Cheng et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Serum selenium concentration at diagnosis and outcome in patients with haematological malignancies

(2011) Jane Stevens et al.   BRITISH JOURNAL OF HAEMATOLOGY

SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease

(2011) Xiao Hong Du et al.   BRITISH JOURNAL OF NUTRITION

Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply

(2011) Susanne Krehl et al.   CARCINOGENESIS

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo

(2011) Richard C. Jin et al.   CIRCULATION

Transactivation of gene expression by NF-κB is dependent on thioredoxin reductase activity

(2011) Jacqueline M. Heilman et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Pathogenicity of an EntericCitrobacter rodentiumInfection Is Enhanced by Deficiencies in the Antioxidants Selenium and Vitamin E

(2011) Allen D. Smith et al.   INFECTION AND IMMUNITY

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis

(2011) Valentina A. Shchedrina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2Emission from Isolated Heart Mitochondria

(2011) Brian A. Stanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein-dependent Up-regulation of Hematopoietic Prostaglandin D2Synthase in Macrophages Is Mediated through the Activation of Peroxisome Proliferator-activated Receptor (PPAR) γ

(2011) Ujjawal H. Gandhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells

(2011) M. Enqvist et al.   JOURNAL OF IMMUNOLOGY

Selenium Levels Affect the IL-4–Induced Expression of Alternative Activation Markers in Murine Macrophages

(2011) Shakira M. Nelson et al.   JOURNAL OF NUTRITION

The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice

(2011) Andréa P de Souza et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

(2011) M. Back et al.   PHARMACOLOGICAL REVIEWS

Would selenium supplementation aid in therapy for Chagas Disease?

(2011) Linda A. Jelicks et al.   TRENDS IN PARASITOLOGY

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

Prostacyclin: An Inflammatory Paradox

(2011) Jeremiah Stitham et al.   Frontiers in Pharmacology

Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients

(2011) C.-H. Guo et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Glutathione Peroxidase 1 Deficiency Attenuates Allergen-Induced Airway Inflammation by Suppressing Th2 and Th17 Cell Development

(2010) Hee Yeon Won et al.   ANTIOXIDANTS & REDOX SIGNALING

mPGES-1 as a target for cancer suppression

(2010) Masako Nakanishi et al.   BIOCHIMIE

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

(2010) Tove Båge et al.   BMC GENOMICS

Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?

(2010) Elias S.J. Arnér   EXPERIMENTAL CELL RESEARCH

Nrf2 target genes are induced under marginal selenium-deficiency

(2010) Mike Müller et al.   Genes and Nutrition

Dietary Selenium Modulates Activation and Differentiation of CD4+ T Cells in Mice through a Mechanism Involving Cellular Free Thiols

(2010) FuKun W. Hoffmann et al.   JOURNAL OF NUTRITION

Selenium inhibits high glucose-induced cyclooxygenase-2 and P-selectin expression in vascular endothelial cells

(2010) Yan-Bo Li et al.   MOLECULAR BIOLOGY REPORTS

The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infection

(2010) Andréa Pereira de Souza et al.   PARASITOLOGY RESEARCH

Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts

(2010) Vu Thi Thu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A pro-resolution mediator, prostaglandin D2, is specifically up-regulated in individuals in long-term remission from ulcerative colitis

(2010) L. Vong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Un inhibidor selectivo de la ciclooxigenasa-2 empeora la función respiratoria y fomenta la actividad de los mastocitos en ratones sensibilizados a la ovalbúmina

(2009) Rosa Torres et al.   ARCHIVOS DE BRONCONEUMOLOGIA

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

(2009) Phyllis Chew et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium

(2009) Lutz Schomburg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenium deficiency impairs host innate immune response and induces susceptibility to Listeria monocytogenes infection

(2009) Chengmin Wang et al.   BMC IMMUNOLOGY

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression

(2009) Bradley A Carlson et al.   BMC IMMUNOLOGY

Prostacyclin receptor/thromboxane receptor interactions and cellular responses in human atherothrombotic disease

(2009) Scott Gleim et al.   Current Atherosclerosis Reports

Importance of oxidative stress in the pathogenesis and treatment of asthma

(2009) Marc A Riedl et al.   Current Opinion in Allergy and Clinical Immunology

Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice

(2009) A. M. Dittrich et al.   EUROPEAN RESPIRATORY JOURNAL

15-Deoxy-Δ12,14-prostaglandin J2 inhibits HIV-1 transactivating protein, Tat, through covalent modification

(2009) Parisa Kalantari et al.   FASEB JOURNAL

NADPH oxidase activity: In the crossroad of neutrophil life and death

(2009) Maria Augusta Arruda   Frontiers in Bioscience-Landmark

Subcutaneous Prostaglandin E2 Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th2 Cytokine Overproduction in House Dust Mite-Sensitive Mice

(2009) Aida Herrerias et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Endothelium-Dependent Vasodilator Effects of Peroxisome Proliferator-Activated Receptor   Agonists via the Phosphatidyl-Inositol-3 Kinase-Akt Pathway

(2009) R. Jimenez et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension

(2009) Kamal K. Mubarak   RESPIRATORY MEDICINE

GPx2 Counteracts PGE2 Production by Dampening COX-2 and mPGES-1 Expression in Human Colon Cancer Cells

(2008) Antje Banning et al.   ANTIOXIDANTS & REDOX SIGNALING

Prostacyclin Prevents Murine Lung Cancer Independent of the Membrane Receptor by Activation of Peroxisomal Proliferator-Activated Receptor  

(2008) R. Nemenoff et al.   Cancer Prevention Research

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thioredoxin Reductase-1 Negatively Regulates HIV-1 Transactivating Protein Tat-dependent Transcription in Human Macrophages

(2008) Parisa Kalantari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoproteins Mediate T Cell Immunity through an Antioxidant Mechanism

(2008) Rajeev K. Shrimali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH

Selenium attenuates pro-inflammatory gene expression in macrophages

(2008) Hema Vunta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Prevalence of Low Selenium Levels in Adult Patients Undergoing Bone Marrow Transplantation: A Brief Communication

(2008) Molouk Hadjibabaie et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis

(2008) Leigh A. Jania et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Effect of vitamin E and selenium supplementation on oxidative stress status in pulmonary tuberculosis patients

(2008) Ensiyeh SEYEDREZAZADEH et al.   RESPIROLOGY

Peroxiredoxins from Trypanosoma cruzi: Virulence factors and drug targets for treatment of Chagas disease?

(2007) María Dolores Piñeyro et al.   GENE