Article
Physiology
Ziqing Li, Wenwei Luo, Shi Fang, Xinyi Chen, Tong Lin, Sihang Zhou, Lili Zhang, Wanqi Yang, Zhenzhen Li, Jiantao Ye, Junjian Wang, Peiqing Liu, Zhuoming Li
Summary: This study reveals that impaired IP receptors can lead to VSMC phenotypic transformation induced by PGI(2), exacerbating vascular remodeling. This is mainly achieved through activation of TP receptors and their downstream signaling cascades, as well as increased distribution of TP receptors on the cell membrane.
Review
Biochemistry & Molecular Biology
Helena Idborg, Sven-Christian Pawelzik
Summary: This article reviews the metabolism of primary prostanoids in humans, summarizes the levels of prostanoid metabolites in healthy individuals, and highlights the importance of existing biomarker studies.
Review
Biochemistry & Molecular Biology
Christopher F. Bennett, Conor T. Ronayne, Pere Puigserver
Summary: Mitochondrial dysfunction plays a significant role in human diseases, primarily due to the oxidative metabolism at the mitochondrial respiratory chain and its connection to redox homeostasis and biosynthetic pathways. Diseases can arise from genetic mutations or environmental factors causing metabolic stress, leading to adaptive or maladaptive responses, potentially underlying pathology. Preclinical therapies targeting these metabolic deficiencies hold therapeutic promise and further understanding of curative processes could significantly impact mitochondrial biology and disease research.
Article
Immunology
Mai M. Abdelmoaty, Pravin Yeapuri, Jatin Machhi, Katherine E. Olson, Farah Shahjin, Vikas Kumar, You Zhou, Jingjing Liang, Kabita Pandey, Arpan Acharya, Siddappa N. Byrareddy, R. Lee Mosley, Howard E. Gendelman
Summary: Following SARS-CoV-2 infection, the host mounts a robust innate immune response characterized by a pro-inflammatory storm, leading to end-organ tissue damage.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Scott W. Walsh, Jerome F. Strauss
Summary: The path to low-dose aspirin therapy for preventing preeclampsia started with the discovery of imbalanced thromboxane and prostacyclin levels in the placentas of affected women in the 1980s. Despite the effectiveness of low-dose aspirin in correcting this imbalance and reducing oxidative stress, some women still develop preeclampsia, possibly due to alterations in placental sphingolipids and hydroxyeicosatetraenoic acids. Further research on aspirin's effects on neutrophils and pregnancy-specific expression of protease-activated receptor 1 is needed for prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Michael O. Glocker, Kwabena F. M. Opuni, Hans-Juergen Thiesen
Summary: This study focuses on the free energy calculations of SARS-CoV-2 Omicron and its receptor binding motives (RBMs). The findings suggest weaker binding to the human receptor and potential implications for viral generation and transmissibility. However, overall disease severity is expected to be reduced due to partial immunity and delayed induction of immune responses.
MEDICINA-LITHUANIA
(2022)
Article
Toxicology
Julie A. Griffith, Krista L. Garner, Elizabeth C. Bowdridge, Evan DeVallance, Kallie J. Schafner, Kevin J. Engles, Thomas P. Batchelor, William T. Goldsmith, Kim Wix, Salik Hussain, Timothy R. Nurkiewicz
Summary: Inhalation of nano-titanium dioxide during pregnancy impairs uterine microvascular prostacyclin and thromboxane function, which may have negative effects on fetal development.
TOXICOLOGICAL SCIENCES
(2022)
Review
Virology
Holly Everest, Phoebe Stevenson-Leggett, Dalan Bailey, Erica Bickerton, Sarah Keep
Summary: This article reviews the interactions between animal and human coronaviruses and their cellular receptors, emphasizing the importance of understanding these interactions for disease prevention and intervention strategies. The role of receptor-binding and glycan-coronavirus interactions in infection, tropism, and pathogenesis is highlighted, with a focus on the need for continued research in this area.
Review
Cardiac & Cardiovascular Systems
Georges Jourdi, Anne Godier, Marie Lordkipanidze, Guillaume Marquis-Gravel, Pascale Gaussem
Summary: Antiplatelet agents, including aspirin and P2Y(12) receptor antagonists, are crucial for the treatment of atherothrombotic events. The shift towards patient-centered precision medicine requires a better understanding of individual risks and benefits associated with different antiplatelet strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Faith H. Brennan, Yang Li, Cankun Wang, Anjun Ma, Qi Guo, Yi Li, Nicole Pukos, Warren A. Campbell, Kristina G. Witcher, Zhen Guan, Kristina A. Kigerl, Jodie C. E. Hall, Jonathan P. Godbout, Andy J. Fischer, Dana M. McTigue, Zhigang He, Qin Ma, Phillip G. Popovich
Summary: This study demonstrates that microglia are necessary for optimal repair after murine spinal cord injury (SCI) using microglia-specific depletion techniques and single cell transcriptomics.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ben Vermaercke, Vincent Bonin, Pierre Vanderhaeghen
Summary: Transplantation of human cortical neurons into the rodent brain offers new opportunities for studying human neural function and disease in vivo, from the molecular to circuit levels.
Article
Pharmacology & Pharmacy
Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne, Michelle L. Halls
Summary: Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Research has shown that sustained elevation of cAMP in the nucleus is necessary for efficient inhibition of PDGF-induced nuclear ERK and fibroblast proliferation in human lung fibroblasts.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell & Tissue Engineering
Oluwafemi Solomon Agboola, Xinglin Hu, Zhiyan Shan, Yanshuang Wu, Lei Lei
Summary: Brain organoids generated from human pluripotent stem cells provide an ideal platform to study cellular interactions and pathophysiology of the human brain. By examining the composition and interactions among neural lineage and non-central nervous system cell types in brain organoids, researchers can uncover previously inaccessible features of neurobiology.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cardiac & Cardiovascular Systems
Jinlv Qin, Guizuo Wang, Dong Han
Summary: This systematic review and meta-analysis demonstrated that selexipag is safe and significantly improves outcomes in patients with pulmonary hypertension. It should be considered as a treatment option for patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Medical Laboratory Technology
Qiuwang Zhang, Chenxi Wang, Anthony Cannavicci, Marie E. Faughnan, Michael J. B. Kutryk
Summary: This study investigated the interaction of ENG with VEGFR2, FGFR1, and TIE2 in primary human ECs, finding that ENG deficiency alters the VEGF/VEGFR2 pathway, potentially playing a role in the pathogenesis of HHT.
TRANSLATIONAL RESEARCH
(2021)
Article
Hematology
Roshni Srivastava, Harshvardhan Rolyan, Yi Xie, Na Li, Neha Bhat, Lingjuan Hong, Fatemehsadat Esteghamat, Adebowale Adeniran, Arnar Geirsson, Jiasheng Zhang, Guanghao Ge, Marcelo Nobrega, Kathleen A. Martin, Arya Mani
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Yi Xie, Allison C. Ostriker, Yu Jin, Haidi Hu, Ashley J. Sizer, Gang Peng, Aaron H. Morris, Changwan Ryu, Erica L. Herzog, Themis Kyriakides, Hongyu Zhao, Alan Dardik, Jun Yu, John Hwa, Kathleen A. Martin
Article
Surgery
Lee D. Ying, Gregory A. Breuer, Matthew O. Hubbard, Geoffrey S. Nadzam, John Hwa, Kathleen A. Martin
Editorial Material
Cardiac & Cardiovascular Systems
Allison C. Ostriker, Kathleen A. Martin
CIRCULATION RESEARCH
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Yi Xie, Kathleen A. Martin
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Yuan Zhang, Yanfei Wang, Li Zhang, Luoxing Xia, Minhui Zheng, Zhi Zeng, Yingying Liu, Timur Yarovinsky, Allison C. Ostriker, Xuejiao Fan, Kai Weng, Meiling Su, Ping Huang, Kathleen A. Martin, John Hwa, Wai Ho Tang
CIRCULATION RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Zhi Zeng, Luoxing Xia, Shunyang Fan, Junmeng Zheng, Jinhong Qin, Xuejiao Fan, Yunfeng Liu, Jun Tao, Yingying Liu, Kang Li, Zhenwei Ling, Yun Bu, Kathleen A. Martin, John Hwa, Renjing Liu, Wai Ho Tang
Summary: The study demonstrates that circMAP3K5 acts as a regulator of neointimal hyperplasia by sequestering miR-22-3p to inhibit TET2 expression, and subsequently affecting vascular smooth muscle cell differentiation and proliferation. Targeting the circMAP3K5/miR-22-3p/TET2 axis may offer a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis.
Review
Cardiac & Cardiovascular Systems
Sean X. Gu, Tarun Tyagi, Kanika Jain, Vivian W. Gu, Seung Hee Lee, Jonathan M. Hwa, Jennifer M. Kwan, Diane S. Krause, Alfred Lee, Stephanie Halene, Kathleen A. Martin, Hyung J. Chun, John Hwa
Summary: Platelet and endothelial dysfunction are essential components of COVID-19 pathology, while cardiovascular risk factors exacerbate the severity of the disease. Patients with pre-existing cardiovascular disease and risk factors are at the highest risk of death from COVID-19.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Allison C. Ostriker, Yi Xie, Raja Chakraborty, Ashley J. Sizer, Yalai Bai, Min Ding, Wen-Liang Song, Anita Huttner, John Hwa, Kathleen A. Martin
Summary: The study found that TET2 is suppressed in CAV and GA, likely mediated by IFN gamma. TET2 helps to protect VSMCs from apoptosis in the context of transplant vasculopathy or IFN gamma stimulation. Enhancing TET2 enzymatic activity with high-dose ascorbic acid reduces VSMC apoptosis and intimal thickening, suggesting that promoting TET2 activity in CAV may be an effective strategy for limiting CAV progression.
Article
Cell Biology
Mingjun Liu, Cristina Espinosa-Diez, Sidney Mahan, Mingyuan Du, Anh T. Nguyen, Scott Hahn, Raja Chakraborty, Adam C. Straub, Kathleen A. Martin, Gary K. Owens, Delphine Gomez
Summary: Epigenetic mechanisms play a crucial role in regulating cell differentiation and function; vascular smooth muscle cells exhibit phenotypic plasticity; the H3K4me2-TET2-miR145 axis is a central epigenetic memory mechanism controlling cell identity and function.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Rachana R. Chandran, Yi Xie, Eunate Gallardo-Vara, Taylor Adams, Rolando Garcia-Milian, Inamul Kabir, Abdul Q. Sheikh, Naftali Kaminski, Kathleen A. Martin, Erica L. Herzog, Daniel M. Greif
Summary: This study reveals that KLF4 plays opposing roles in PDGFR-beta(+) cells and SMA(+) cells during lung fibrosis, with the upregulation of KLF4 inducing fibrosis signaling in PDGFR-beta(+) cells and the reduction of KLF4 exacerbating fibrosis through macrophage accumulation in SMA(+) cells. The findings underscore the importance of further investigating interactions between distinct mesenchymal cell types in the context of lung fibrosis.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Arya Mani, John Hwa, Kathleen A. Martin
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Kanika Jain, Tarun Tyagi, Jing Du, Xiaoyue Hu, Kanchi Patell, Kathleen A. Martin, John Hwa
Summary: This study reveals that activation of unfolded protein response (UPR) in anucleate platelets can be independent of genomic regulation, with selective induction specific to the source and severity of stress. Each UPR pathway plays a key role and can differentially modulate platelet activation pathways and phenotype.
CIRCULATION RESEARCH
(2022)
Article
Immunology
Tarun Tyagi, Kanika Jain, Timur O. Yarovinsky, Michael Chiorazzi, Jing Du, Cecilia Castro, Jules Griffin, Asawari Korde, Kathleen A. Martin, Shervin S. Takyar, Richard A. Flavell, Abhijit A. Patel, John Hwa
Summary: This study reveals the immunosuppressive role of platelets in tumor growth and identifies the platelet protein TLT-1 as a key player in suppressing CD8 T cells. Anti-TLT-1 antibody shows potential as a therapeutic option to rescue T cell function and reduce tumor size. Clinically, higher TLT-1 levels are associated with reduced survival in non-small cell lung cancer patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Editorial Material
Hematology
Brendan J. O'Brien, Kathleen A. Martin, Stefan Offermanns
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)