Review
Biochemistry & Molecular Biology
Katarzyna Kaczynska, Dominika Zajac, Piotr Wojciechowski, Monika Jampolska
Summary: Regulatory peptides play a crucial role in the pathogenesis of asthma, exacerbating symptoms for some while ameliorating them for others. Interacting with peptide receptors located in the lungs or on immune cells offers new therapeutic possibilities for treating asthma, especially in cases where current therapies are ineffective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xingang Li, Yuanting Pang, Yiwang Zhong, Zhandong Cai, Qibin Ma, Ke Wen, Hai Nian
Summary: In this study, a tau-like glutathione transferase family gene named GmGSTU23 was identified in soybean, which showed a concentration-time-specific expression pattern in response to salt stress. Transgenic lines with GmGSTU23 displayed enhanced salt tolerance, root length, and fresh weight compared to the wild type. Changes in glutathione pools and associated enzyme activity were observed, indicating that GmGSTU23 enhances the activity of glutathione transferase to scavenge reactive oxygen species and glutathione, thereby conferring enhanced tolerance to salt stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Gina N. Calco, Becky J. Proskocil, David B. Jacoby, Allison D. Fryer, Zhenying Nie
Summary: Increased insulin levels are associated with obesity-related airway hyperreactivity and asthma. Metformin, an antidiabetic drug, was found to prevent the development of airway hyperreactivity in male rats on a high-fat diet by reducing circulating insulin levels. This study suggests that insulin-targeting medications may be an effective treatment for obesity-related asthma.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xin Dai, Shyamali C. C. Dharmage, Caroline J. J. Lodge
Summary: Oxidative stress is a major pathophysiological mechanism for chronic respiratory disease. GST genes play important roles in antioxidant defenses and may impact respiratory health. Future research should consider gene-gene interactions, multiple environmental exposures, and gender in these complex associations.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Allergy
Benjamin P. Hurrell, Doumet Georges Helou, Pedram Shafiei-Jahani, Emily Howard, Jacob D. Painter, Christine Quach, Omid Akbari
Summary: This study reveals the important role of cannabinoid CB2 signaling in modulating the development of airway inflammation in ILC2s, both in mice and humans. CB2 signaling stimulates the proliferation and function of ILC2s, leading to increased airway hyperreactivity and lung inflammation. These findings are significant for understanding the pathogenesis of asthma and identifying new therapeutic targets.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Physiology
Becky J. Proskocil, Gina N. Calco, Zhenying Nie
Summary: This study found that hyperinsulinemia increases bronchoconstriction induced by the vagus nerve in obese rats, as well as significantly increases methacholine-induced airway smooth muscle contraction. Insulin enhances intracellular calcium and smooth muscle contraction, providing insights into potential asthma treatment targets.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Physiology
Llilian Arzola-Martinez, Rebeca Benavente, Genesis Vega, Mariana Rios, Wendy Fonseca, Andrew J. Rasky, Susan Morris, Nicholas W. Lukacs, Manuel J. Villalon
Summary: Allergic asthma is characterized by chronic airway inflammation in response to various triggers, such as inhaled allergens. High levels of extracellular ATP (eATP) in fluids from asthma patients can negatively impact mucociliary clearance (MCC) effectiveness. Inhibiting specific ATP release channels, such as pannexin1, may offer a pharmacological alternative to improve airway clearance and reduce airway hyperresponsiveness in allergic asthma.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dominika Zajac, Piotr Wojciechowski
Summary: Vitamins play a crucial role in the development and management of asthma, affecting symptoms such as bronchial hyperreactivity, airway inflammation, oxidative stress, and airway remodeling. The intake and levels of vitamins are also associated with the risk of asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Wei Shen, Hian Kee Lee, Sheng Tang, Lina Wang, Jinghui Zhang, Xuemin Zeng
Summary: In this study, a pH-dependent polydopamine-coated vesicle/Fe3O4 magnetic aqueous-aqueous single-drop microreactor (SDMR) was proposed for the direct detection of glutathione S-transferase (GST) in biological samples. This method allows the extraction and enrichment of GST from complex matrices and reduces interferences from matrix effects. It can be used for the direct detection of GST in genuine urine and blood without any sample pretreatment.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Larisa Obukhova, Tatiana Kopytova, Elena Murach, Natalya Shchelchkova, Claudia Kontorshchikova, Igor Medyanik, Natalia Orlinskaya, Artem Grishin, Michael Kontorshchikov, Dariya Badanina
Summary: This research investigates the relationship between glutathione metabolism parameters and immunohistochemical characteristics of glial tumors. It finds that the level of nuclear protein Ki67 and the presence of IDH1 mutation have the most pronounced relationship with glutathione metabolism.
Article
Biochemistry & Molecular Biology
Yuya Aono, Yuzo Suzuki, Ryo Horiguchi, Yusuke Inoue, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Shinji Mii, Masahide Takahashi, Takafumi Suda
Summary: CD109 plays an important role in the development of asthma. Its deficiency reduces airway hyperreactivity and eosinophilic inflammation, as well as Th2 cytokine expression. Therefore, CD109 may be a novel therapeutic target for asthma.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Agronomy
Yushi Jiang, Yuzhe Zhang, Ruijie Duan, Jiayi Fan, Peng Jiao, Hongji Sun, Shuyan Guan, Siyan Liu
Summary: ZmGST26 was found to be downregulated in maize under drought stress. Overexpression of ZmGST26 in Arabidopsis resulted in increased sensitivity to drought stress and ABA, as well as inhibited ABA-mediated stomatal closure. ZmGST26 overexpression decreased the resistance of Arabidopsis to drought stress and led to the accumulation of reactive oxygen species.
Article
Neurosciences
Bo Cheng, Xiaoliang Hong, Linfang Wang, Yuanyuan Cao, Dengli Qin, Han Zhou, Dianshuai Gao
Summary: Curzerene inhibits the progression of glioma by suppressing the expression of GSTA4 and matrix metalloproteinase 9, and inhibiting the activation of the mTOR pathway. It also induces apoptosis and reduces invasion and migration of glioma cells. In vivo studies have shown that Curzerene significantly inhibits tumor growth and prolongs survival time.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Physiology
Ryan R. Jamieson, Suzanne E. Stasiak, Samuel R. Polio, Ralston D. Augspurg, Caroline A. McCormick, Jeffrey W. Ruberti, Harikrishnan Parameswaran
Summary: The current therapeutic approach to asthma targets inflammation and reducing airway smooth muscle force, but research shows that even when inflammation is controlled, excessive bronchoconstriction can still occur. Increasing the stiffness of the extracellular matrix is found to be sufficient to cause excessive airway constriction even without inflammatory signals, providing an independent mechanism for sustaining airway hyperreactivity in asthmatics.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Environmental Sciences
Doerthe Brueggmann, Lena-Katharina Loehlein, Frank Louwen, David Quarcoo, Jenny Jaque, Doris Klingelhoefer, David A. Groneberg
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2015)
Article
Infectious Diseases
David Quarcoo, Doerthe Brueggmann, Doris Klingelhoefer, David A. Groneberg
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Review
Public, Environmental & Occupational Health
Menen E. Mund, David Quarcoo, Christoph Gyo, Doerthe Brueggmann, David A. Groneberg
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2015)
Article
Gastroenterology & Hepatology
Fong-Fong Chu, R. Steven Esworthy, James H. Doroshow, Binghui Shen
WORLD JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Public, Environmental & Occupational Health
Doerthe Brueggmann, Alexandra Elizabeth-Martinez, Doris Klingelhoefer, David Quarcoo, Jenny M. Jaque, David A. Groneberg
Article
Public, Environmental & Occupational Health
Christoph Gyo, Michael Boll, Doerthe Brueggmann, Doris Klingelhoefer, David Quarcoo, David A. Groneberg
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2016)
Review
Public, Environmental & Occupational Health
Menen E. Mund, Christoph Gyo, Doerthe Brueggmann, David Quarcoo, David A. Groneberg
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Fong-Fong Chu, R. Steven Esworthy, James H. Doroshow, Helmut Grasberger, Agnes Donko, Thomas L. Leto, Qiang Gao, Binghui Shen
Meeting Abstract
Biochemistry & Molecular Biology
Steven Esworthy, Ursula Cota, Binghui Shen, Qiang Gao, James H. Doroshow, Fong-Fong Chu
FREE RADICAL BIOLOGY AND MEDICINE
(2014)
Review
Computer Science, Interdisciplinary Applications
David A. Groneberg, Doris Klingelhoefer, Doerthe Brueggmann, Cristian Scutaru, Axel Fischer, David Quarcoo
Article
Medicine, Research & Experimental
Fong-Fong Chu, R. Steven Esworthy, Binghui Shen, Qiang Gao, James H. Doroshow
Article
Microbiology
Fong-Fong Chu, R. Steven Esworthy, Binghui Shen, James H. Doroshow
Article
Public, Environmental & Occupational Health
D. Quarcoo, M. Bundschuh
ZENTRALBLATT FUR ARBEITSMEDIZIN ARBEITSSCHUTZ UND ERGONOMIE
(2015)
Article
Public, Environmental & Occupational Health
M. Bundschuh, D. Klingelhoefer, D. A. Groneberg, D. Quarcoo
ZENTRALBLATT FUR ARBEITSMEDIZIN ARBEITSSCHUTZ UND ERGONOMIE
(2015)
Article
Biochemistry & Molecular Biology
James H. Doroshow, R. Steven Esworthy, Fong-Fong Chu
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2020)