Enhancing Mitochondrial Health to Treat Hypertension

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

(2018) Aliz Szabo et al.   BIOCHEMICAL PHARMACOLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Mitoprotection preserves the renal vasculature in porcine metabolic syndrome

(2018) Alfonso Eirin et al.   EXPERIMENTAL PHYSIOLOGY

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

(2018) Rogério Faustino Ribeiro Junior et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiolipin Regulates Mitophagy through the Protein Kinase C Pathway

(2017) Zheni Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The metabolic syndrome induces early changes in the swine renal medullary mitochondria

(2017) Alfonso Eirin et al.   Translational Research

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension

(2016) Alfonso Eirin et al.   Journal of the American Heart Association

CDC Grand Rounds: A Public Health Approach to Detect and Control Hypertension

(2016) Rikita Merai et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage

(2015) T. Suzuki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome

(2015) M. Sumida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease

(2014) Alfonso Eirin et al.   CARDIOVASCULAR RESEARCH

Mitochondrial injury and dysfunction in hypertension-induced cardiac damage

(2014) A. Eirin et al.   EUROPEAN HEART JOURNAL

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

(2014) Konstantinos Palikaras et al.   EXPERIMENTAL GERONTOLOGY

Valsartan Regulates Myocardial Autophagy and Mitochondrial Turnover in Experimental Hypertension

(2014) Xin Zhang et al.   HYPERTENSION

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Salt-sensitive hypertension in mitochondrial superoxide dismutase deficiency is associated with intra-renal oxidative stress and inflammation

(2013) Kyubok Jin et al.   Clinical and Experimental Nephrology

Fenofibrate lowers blood pressure in salt-sensitive but not salt-resistant hypertension

(2013) Kimberly Gilbert et al.   JOURNAL OF HYPERTENSION

Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension

(2013) Alfonso Eirin et al.   JOURNAL OF HYPERTENSION

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function

(2013) Jennifer McLachlan et al.   JOURNAL OF HYPERTENSION

Peroxisome Proliferator-Activated Receptor δ Agonist, HPP593, Prevents Renal Necrosis under Chronic Ischemia

(2013) Larisa V. Fedorova et al.   PLoS One

Gsk-3βInhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

(2013) Luisa F. González Arbeláez et al.   Biomed Research International

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Scavenging of NADPH oxidase-derived superoxide anions improves depressed baroreflex sensitivity in spontaneously hypertensive rats

(2012) DD Guimarães et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A Mitochondrial Permeability Transition Pore Inhibitor Improves Renal Outcomes After Revascularization in Experimental Atherosclerotic Renal Artery Stenosis

(2012) Alfonso Eirin et al.   HYPERTENSION

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

(2011) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Maternally Inherited Essential Hypertension Is Associated With the Novel 4263A>G Mutation in the Mitochondrial tRNA Ile Gene in a Large Han Chinese Family

(2011) Shiwen Wang et al.   CIRCULATION RESEARCH

Identification and characterization of a functional mitochondrial angiotensin system

(2011) P. M. Abadir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARα agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity

(2010) Xiaoyang Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Hypertensive Hypertrophied Myocardium Is Vulnerable to Infarction and Refractory to Erythropoietin-Induced Protection

(2010) Toshiyuki Yano et al.   HYPERTENSION

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Role of Glycogen Synthase Kinase-3β in Cardioprotection

(2009) Magdalena Juhaszova et al.   CIRCULATION RESEARCH

Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

(2009) Delyth Graham et al.   HYPERTENSION

The role of calcium-independent phospholipase A2in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

(2009) Derek K. Zachman et al.   JOURNAL OF LIPID RESEARCH

Antioxidant SOD Mimetic Prevents NADPH Oxidase-Induced Oxidative Stress and Renal Damage in the Early Stage of Experimental Diabetes and Hypertension

(2008) Elisa B.M.I. Peixoto et al.   AMERICAN JOURNAL OF NEPHROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A2, Ca2+, and Superoxide Anion Levels

(2008) A. B. Garcia-Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS