Rho Kinase Inhibition by Fasudil Attenuates Adriamycin-Induced Chronic Heart Injury

Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells

(2018) Ramaswamy Kannappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR-dependent pathway

(2018) Liang Liu et al.   BASIC RESEARCH IN CARDIOLOGY

MicroRNA-29b Regulates the Mitochondria-Dependent Apoptotic Pathway by Targeting Bax in Doxorubicin Cardiotoxicity

(2018) Xibo Jing et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes

(2018) Cameron S. Brand et al.   CELLULAR SIGNALLING

The RhoA/ROCK pathway mediates high glucose-induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways

(2018) Hong Zhou et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells

(2018) Alessandra Antunes dos Santos et al.   FOOD AND CHEMICAL TOXICOLOGY

Fasudil alleviates pressure overload-induced heart failure by activating Nrf2-mediated antioxidant responses

(2018) Peng Guan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tenascin-C promotes chronic pressure overload-induced cardiac dysfunction, hypertrophy and myocardial fibrosis

(2018) Bruno K. Podesser et al.   JOURNAL OF HYPERTENSION

Apremilast prevent doxorubicin-induced apoptosis and inflammation in heart through inhibition of oxidative stress mediated activation of NF-κB signaling pathways

(2018) Faisal Imam et al.   Pharmacological Reports

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

(2018) Chhanda Bose et al.   PLoS One

Interleukin-12p35 Knock Out Aggravates Doxorubicin-Induced Cardiac Injury and Dysfunction by Aggravating the Inflammatory Response, Oxidative Stress, Apoptosis and Autophagy in Mice

(2018) Jing Ye et al.   EBioMedicine

Inhibition of cyclin-dependent kinase 2 protects against doxorubicin-induced cardiomyocyte apoptosis and cardiomyopathy

(2018) Peng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of fasudil on pulmonary hypertension in clinical practice

(2017) Yiqing Zhang et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats

(2016) Hatice Adiguzel Dundar et al.   ARCHIVES OF MEDICAL RESEARCH

Rho Kinases and Cardiac Remodeling

(2016) Toru Shimizu et al.   CIRCULATION JOURNAL

Geranylgeranylacetone Blocks Doxorubicin-Induced Cardiac Toxicity and Reduces Cancer Cell Growth and Invasion through RHO Pathway Inhibition

(2014) P. Sysa-Shah et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart

(2014) NAN WU et al.   Molecular Medicine Reports

ROCK1 Deficiency Enhances Protective Effects of Antioxidants against Apoptosis and Cell Detachment

(2014) Michelle Surma et al.   PLoS One

Rho-Kinase Activation in Leukocytes Plays a Pivotal Role in Myocardial Ischemia/Reperfusion Injury

(2014) Katsunori Kitano et al.   PLoS One

Amelioration of adriamycin-induced cardiotoxicity bySalsola kaliaqueous extract is mediated by lowering oxidative stress

(2014) Heba A. Aniss et al.   REDOX REPORT

Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116 RIP 3 ‐Dependent RhoA Inhibition

(2014) Gwennan André et al.   Journal of the American Heart Association

The role of autophagy in doxorubicin-induced cardiotoxicity

(2013) Amie J. Dirks-Naylor   LIFE SCIENCES

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Effect of oxidative stress on ventricular arrhythmia in rabbits with adriamycin-induced cardiomyopathy

(2012) Li He et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Berberine Inhibits Doxorubicin-Triggered Cardiomyocyte Apoptosis via Attenuating Mitochondrial Dysfunction and Increasing Bcl-2 Expression

(2012) Xiuxiu Lv et al.   PLoS One

Transcriptome Profiling of Peripheral Blood Cells Identifies Potential Biomarkers for Doxorubicin Cardiotoxicity in a Rat Model

(2012) Valentina K. Todorova et al.   PLoS One

Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats

(2011) Tarek A. Abd El-Aziz et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol

(2011) Goncalo C. Pereira et al.   CURRENT PHARMACEUTICAL DESIGN

Preventive effects of fasudil on adriamycin-induced cardiomyopathy: Possible involvement of inhibition of RhoA/ROCK pathway

(2011) Na Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Rho-Kinase in Development and Heart Failure: Insights From Genetic Models

(2011) Jianjian Shi et al.   PEDIATRIC CARDIOLOGY

Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats

(2010) Kalender Ozdogan et al.   Anadolu Kardiyoloji Dergisi-The Anatolian Journal of Cardiology

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Role of Curcuma longa Against Doxorubicin (Adriamycin)-Induced Toxicity in Rats

(2009) Ragaa Hosny Mohamad et al.   JOURNAL OF MEDICINAL FOOD