SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia

T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies

(2018) Eduardo Vadillo et al.   BLOOD REVIEWS

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

(2017) Antonia Cagnetta et al.   HAEMATOLOGICA

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

(2017) P Richter-Pechańska et al.   Blood Cancer Journal

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

(2017) Antonia Cagnetta et al.   HAEMATOLOGICA

Therapeutic targeting of HMGB1 during experimental sepsis modulates the inflammatory cytokine profile to one associated with improved clinical outcomes

(2017) Natalie E. Stevens et al.   Scientific Reports

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage

(2016) Jiaxiang Shao et al.   Protein & Cell

Sirtuins at the Breaking Point: SIRT6 in DNA Repair

(2016) David B. Lombard   Aging-US

SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair

(2016) Ronald A. McCord et al.   Aging-US

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

(2016) Michael Van Meter et al.   Aging-US

Autophagy positively regulates DNA damage recognition by nucleotide excision repair

(2015) Lei Qiang et al.   Autophagy

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy

(2015) Minghua Yang et al.   Autophagy

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

(2015) Zhu Xu et al.   CELL CYCLE

Autophagy in DNA Damage Response

(2015) Piotr Czarny et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HMGB1 translocation is involved in the transformation of autophagy complexes and promotes chemoresistance in leukaemia

(2015) QIAN KONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer

(2015) Yoko Azuma et al.   JOURNAL OF SURGICAL ONCOLOGY

Role of moesin in HMGB1-stimulated severe inflammatory responses

(2015) Min-Su Han et al.   THROMBOSIS AND HAEMOSTASIS

Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathways

(2014) Ying Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling

(2014) Jian Y. Zou et al.   PLoS One

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia

(2013) Ok-Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling

(2013) Debra Toiber et al.   MOLECULAR CELL

SIRT6 exhibits nucleosome-dependent deacetylase activity

(2013) R. Gil et al.   NUCLEIC ACIDS RESEARCH

Regulation of HMGB1 release by inflammasomes

(2013) Ben Lu et al.   Protein & Cell

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Unknown

(2012) Kasey Davis et al.   MOLECULAR MEDICINE

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

High-mobility group box 1 and cancer

(2010) Daolin Tang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HMG modifications and nuclear function

(2010) Qingchun Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism

(2009) Y. J. Oh et al.   JOURNAL OF IMMUNOLOGY

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Poly ADP-ribose polymerase-1: An international molecule of mystery

(2008) Bethany C. Woodhouse et al.   DNA REPAIR