Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

(2016) V. Gianfelici et al.   HAEMATOLOGICA

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

(2016) V. Gianfelici et al.   HAEMATOLOGICA

Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes

(2016) María Abáigar et al.   PLoS One

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

(2015) C. Vicente et al.   HAEMATOLOGICA

Pharmacological reactivation of p53 as a strategy to treat cancer

(2015) J. Zawacka-Pankau et al.   JOURNAL OF INTERNAL MEDICINE

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

(2015) C. Vicente et al.   HAEMATOLOGICA

TP53 mutations occur in 15.7% of ALL and are associated with MYC-rearrangement, low hypodiploidy, and a poor prognosis

(2014) A. Stengel et al.   BLOOD

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia

(2014) C. Shochat et al.   BLOOD

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

(2014) J. Irving et al.   BLOOD

Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol

(2014) N. Bolli et al.   HAEMATOLOGICA

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

(2014) O. R. Bandapalli et al.   HAEMATOLOGICA

ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

(2014) Ellen L. Hedditch et al.   JNCI-Journal of the National Cancer Institute

ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53

(2014) Jianhong Zhang et al.   Nature Communications

Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

(2013) P. Van Vlierberghe et al.   BLOOD

NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia

(2013) O. R. Bandapalli et al.   HAEMATOLOGICA

ALL-REZ BFM - The Consecutive Trials for Children with Relapsed Acute Lymphoblastic Leukemia

(2013) G. Henze et al.   KLINISCHE PADIATRIE

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

(2013) Zeynep Kalender Atak et al.   PLoS Genetics

How I treat relapsed childhood acute lymphoblastic leukemia

(2012) F. Locatelli et al.   BLOOD

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

(2012) L. Zuurbier et al.   HAEMATOLOGICA

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

(2012) Sören Lehmann et al.   JOURNAL OF CLINICAL ONCOLOGY

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

(2011) M. Schrappe et al.   BLOOD

Mutations and Deletions of the TP53 Gene Predict Nonresponse to Treatment and Poor Outcome in First Relapse of Childhood Acute Lymphoblastic Leukemia

(2011) Jana Hof et al.   JOURNAL OF CLINICAL ONCOLOGY

Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias

(2011) Chen Shochat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Long-Term Outcome in Children With Relapsed Acute Lymphoblastic Leukemia After Time-Point and Site-of-Relapse Stratification and Intensified Short-Course Multidrug Chemotherapy: Results of Trial ALL-REZ BFM 90

(2010) Gesche Tallen et al.   JOURNAL OF CLINICAL ONCOLOGY

NOTCH mutations as prognostic markers in T-ALL

(2010) A Ferrando   LEUKEMIA

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

(2010) C Kox et al.   LEUKEMIA

PHF6 mutations in T-cell acute lymphoblastic leukemia

(2010) Pieter Van Vlierberghe et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

MutationTaster evaluates disease-causing potential of sequence alterations

(2010) Jana Marie Schwarz et al.   NATURE METHODS

VarScan: variant detection in massively parallel sequencing of individual and pooled samples

(2009) Daniel C. Koboldt et al.   BIOINFORMATICS

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-  and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

(2009) M. Remke et al.   BLOOD

Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia

(2009) D. Krieger et al.   HAEMATOLOGICA

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia

(2008) Pieter Van Vlierberghe et al.   BRITISH JOURNAL OF HAEMATOLOGY

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE