Pulmonary hypertension in chronic obstructive pulmonary disease

Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice

(2019) Kengo Koike et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Arterial Histological Lesions in COPD Patients with Severe Pulmonary Hypertension

(2019) Vincent Bunel et al.   CHEST

Arterial Vascular Pruning, Right Ventricular Size and Clinical Outcomes in COPD

(2019) George R Washko et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Riociguat for treatment of pulmonary hypertension in COPD – a translational study

(2019) Alexandra Pichl et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary Vascular Density: Comparison of Findings on CT Imaging with Histology

(2019) Farbod N. Rahaghi et al.   EUROPEAN RESPIRATORY JOURNAL

Therapeutic effects of soluble guanylate cyclase stimulation on pulmonary hemodynamics and emphysema development in guinea pigs chronically exposed to cigarette smoke

(2019) Tanja Paul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Diagnostic and Therapeutic Gaps in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease

(2019) Marco Canepa et al.   JACC-Heart Failure

AMD3100 ameliorates cigarette smoke-induced emphysema-like manifestations in mice

(2018) Daria Barwinska et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mild Elevation of Pulmonary Arterial Pressure as a Predictor of Mortality

(2018) Philipp Douschan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Vascular Involvement in COPD - Is There a Pulmonary Vascular Phenotype?

(2018) Gabor Kovacs et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Should patients with pulmonary hypertension fly and climb?

(2018) Gabor Kovacs et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial

(2018) Jens M Hohlfeld et al.   Lancet Respiratory Medicine

Pulmonary hypertension due to lung diseases: Updated recommendations from the Cologne Consensus Conference 2018

(2018) Horst Olschewski et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hyperpolarized 3 He MRI Ventilatory Apparent Diffusion Coefficient of Alpha-1 Antitrypsin Deficiency

(2018) Andrew Westcott et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Pulmonary hypertension in chronic lung disease and hypoxia

(2018) Steven D. Nathan et al.   EUROPEAN RESPIRATORY JOURNAL

Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model

(2017) Ágnes Kemény et al.   ENVIRONMENTAL POLLUTION

An official European Respiratory Society statement: pulmonary haemodynamics during exercise

(2017) Gabor Kovacs et al.   EUROPEAN RESPIRATORY JOURNAL

Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial

(2017) Patrizio Vitulo et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Chronic use of PAH-specific therapy in World Health Organization Group III Pulmonary Hypertension: a systematic review and meta-analysis

(2017) Kurt W. Prins et al.   Pulmonary Circulation

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary vasculature in COPD: The silent component

(2016) Isabel Blanco et al.   RESPIROLOGY

Characterization of a Mouse Model of Emphysema Induced by Multiple Instillations of Low-Dose Elastase

(2016) Milena V. Oliveira et al.   Frontiers in Physiology

Sildenafil in a cigarette smoke-induced model of COPD in the guinea-pig

(2015) David Domínguez-Fandos et al.   EUROPEAN RESPIRATORY JOURNAL

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

(2015) Blaine Phillips et al.   FOOD AND CHEMICAL TOXICOLOGY

Heart Failure and Respiratory Hospitalizations Are Reduced in Patients With Heart Failure and Chronic Obstructive Pulmonary Disease With the Use of an Implantable Pulmonary Artery Pressure Monitoring Device

(2015) Jason S. Krahnke et al.   JOURNAL OF CARDIAC FAILURE

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

(2015) Michael Seimetz et al.   PLoS One

COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity?

(2015) Miranda Kirby et al.   RADIOLOGY

Pulmonary Arterial Hypertension-Specific Drug Therapy in COPD Patients with Severe Pulmonary Hypertension and Mild-to-Moderate Airflow Limitation

(2015) George Calcaianu et al.   RESPIRATION

Multi-institutional retrospective cohort study of patients with severe pulmonary hypertension associated with respiratory diseases

(2015) Nobuhiro Tanabe et al.   RESPIROLOGY

Acute Effects of Riociguat in Borderline or Manifest Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease

(2015) Hossein A. Ghofrani et al.   Pulmonary Circulation

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension

(2014) Jiwang Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Using Pulmonary Imaging to Move Chronic Obstructive Pulmonary Disease beyond FEV1

(2014) Harvey O. Coxson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke–induced Pulmonary Hypertension and Emphysema

(2014) Norbert Weissmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Outcome of Patients with Severe PH due to Lung Disease with and without Targeted Therapy

(2014) Tobias J. Lange et al.   Cardiovascular Therapeutics

Characterization of Patients With Borderline Pulmonary Arterial Pressure

(2014) Gabor Kovacs et al.   CHEST

Cor Pulmonale Parvus in Chronic Obstructive Pulmonary Disease and Emphysema

(2014) Steven M. Kawut et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial

(2014) Andrew R Goudie et al.   Lancet Respiratory Medicine

Computed Tomographic Measures of Pulmonary Vascular Morphology in Smokers and Their Clinical Implications

(2013) Raúl San José Estépar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung

(2013) Toru Nyunoya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Trends in the Prevalence of Obstructive and Restrictive Lung Function Among Adults in the United States

(2013) Earl S. Ford et al.   CHEST

Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial

(2013) Isabel Blanco et al.   EUROPEAN RESPIRATORY JOURNAL

Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension

(2013) P. Trip et al.   EUROPEAN RESPIRATORY JOURNAL

Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease

(2013) Jinkyeong Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Pulmonary Hypertension in Chronic Lung Diseases

(2013) Werner Seeger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?

(2013) Maike Leberl et al.   Frontiers in Physiology

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ventilatory and Cardiocirculatory Exercise Profiles in COPD

(2012) Bart G. Boerrigter et al.   CHEST

Pulmonary Inflammatory Reaction and Structural Changes Induced by Cigarette Smoke Exposure in the Guinea Pig

(2012) David Domínguez-Fandos et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Sildenafil for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial

(2012) David J. Lederer et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Pulmonary hypertension due to chronic lung disease: Updated Recommendations of the Cologne Consensus Conference 2011

(2012) Marius M. Hoeper et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pulmonary Arterial Enlargement and Acute Exacerbations of COPD

(2012) J. Michael Wells et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence for Adult Lung Growth in Humans

(2012) James P. Butler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Effects of Aerosolized Iloprost in COPD Related Pulmonary Hypertension - A Randomized Controlled Crossover Trial

(2012) Lucas Boeck et al.   PLoS One

Safety and accuracy of a wireless pulmonary artery pressure monitoring system in patients with heart failure

(2011) William T. Abraham et al.   AMERICAN HEART JOURNAL

Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease

(2011) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

(2011) Michael Seimetz et al.   CELL

Statin Therapy is Associated with Decreased Pulmonary Vascular Pressures in Severe COPD

(2011) Robert M. Reed et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre

(2011) J. Hurdman et al.   EUROPEAN RESPIRATORY JOURNAL

Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke–induced emphysema in mice

(2011) Matthias Clauss et al.   JOURNAL OF CLINICAL INVESTIGATION

Cigarette Smoking and Inflammation

(2011) J. Lee et al.   JOURNAL OF DENTAL RESEARCH

Statin Reverses Smoke-induced Pulmonary Hypertension and Prevents Emphysema but Not Airway Remodeling

(2010) Joanne L. Wright et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette Smoke Extracts Promote Vascular Smooth Muscle Cell Proliferation and Enhances Contractile Responses in the Vasculature and Airway

(2010) Cang-Bao Xu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inflammation, immunological reaction and role of infection in pulmonary hypertension

(2010) S.S. Pullamsetti et al.   CLINICAL MICROBIOLOGY AND INFECTION

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

(2010) Toshinori Yoshida et al.   NATURE MEDICINE

Categorization and impact of pulmonary hypertension in patients with advanced COPD

(2010) Michael J. Cuttica et al.   RESPIRATORY MEDICINE

Cardiovascular events in patients with COPD: TORCH Study results

(2010) P. M. A. Calverley et al.   THORAX

Palifermin Induces Alveolar Maintenance Programs in Emphysematous Mice

(2009) Ali Ö. Yildirim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stimulation of Sphingosine 1-Phosphate Signaling as an Alveolar Cell Survival Strategy in Emphysema

(2009) Khalil J. Diab et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hemodynamic and Gas Exchange Effects of Sildenafil in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension

(2009) Isabel Blanco et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease

(2009) Betty S. van der Veen et al.   ANTIOXIDANTS & REDOX SIGNALING

Impact of Pulmonary Artery Pressure on Exercise Function in Severe COPD

(2009) Michael W. Sims et al.   CHEST

Pulmonary Hypertension in COPD: A Review and Consideration of the Role of Arterial Vasodilators

(2009) Charles D. Burger   COPD-Journal of Chronic Obstructive Pulmonary Disease

Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary Disease

(2009) Joan Albert Barberà et al.   DRUGS

Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology

(2009) Nathaniel Mark Hawkins et al.   EUROPEAN JOURNAL OF HEART FAILURE

Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

(2009) G. Kovacs et al.   EUROPEAN RESPIRATORY JOURNAL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease

(2009) Giuseppe Valerio et al.   Therapeutic Advances in Respiratory Disease

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice

(2008) Saeko Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Vascular Involvement in COPD

(2008) Víctor I. Peinado et al.   CHEST

Left Ventricular Diastolic Dysfunction in Patients With COPD in the Presence and Absence of Elevated Pulmonary Arterial Pressure

(2008) Georg-Christian Funk et al.   CHEST

Pulmonary hypertension in COPD

(2008) A. Chaouat et al.   EUROPEAN RESPIRATORY JOURNAL

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

(2008) R. T. Schermuly et al.   EUROPEAN RESPIRATORY JOURNAL

A randomised, controlled trial of bosentan in severe COPD

(2008) D. Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular pathogenesis of emphysema

(2008) Laimute Taraseviciene-Stewart et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice

(2007) H. Fehrenbach et al.   EUROPEAN RESPIRATORY JOURNAL

Sildenafil treatment in COPD does not affect stroke volume or exercise capacity

(2007) H. Rietema et al.   EUROPEAN RESPIRATORY JOURNAL