Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice

(2014) Norbert Weissmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke–induced Pulmonary Hypertension and Emphysema

(2014) Norbert Weissmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tadalafil in patients with chronic obstructive pulmonary disease: a randomised, double-blind, parallel-group, placebo-controlled trial

(2014) Andrew R Goudie et al.   Lancet Respiratory Medicine

Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial

(2013) Isabel Blanco et al.   EUROPEAN RESPIRATORY JOURNAL

Sildenafil Potentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial Smooth Muscle Cells and in Experimental Pulmonary Hypertension

(2012) Jun Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sildenafil for COPD: A Randomized Crossover Trial

(2012) Todd Bull et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Sildenafil for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Trial

(2012) David J. Lederer et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial

(2012) Marius M. Hoeper et al.   EUROPEAN RESPIRATORY JOURNAL

Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H2O2via mechanisms involving AP-1 activation

(2012) Manuel Mata et al.   FREE RADICAL RESEARCH

Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats

(2011) Yvonne P. de Visser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

(2011) Michael Seimetz et al.   CELL

Riociguat for the treatment of pulmonary hypertension

(2011) Ralph T Schermuly et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice

(2010) Sergey Udalov et al.   BMC Pulmonary Medicine

Hemodynamic and Gas Exchange Effects of Sildenafil in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension

(2009) Isabel Blanco et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

Effects of Roflumilast, a Phosphodiesterase-4 Inhibitor, on Hypoxia- and Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) M. Izikki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Vascular Involvement in COPD

(2008) Víctor I. Peinado et al.   CHEST

Changes in elastic fibres in the small airways and alveoli in COPD

(2008) P. N. Black et al.   EUROPEAN RESPIRATORY JOURNAL

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

(2008) R. T. Schermuly et al.   EUROPEAN RESPIRATORY JOURNAL

Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia

(2008) K. Woyda et al.   EUROPEAN RESPIRATORY JOURNAL

Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD

(2008) Sebastiaan Holverda et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition

(2007) E. Dony et al.   EUROPEAN RESPIRATORY JOURNAL

Sildenafil treatment in COPD does not affect stroke volume or exercise capacity

(2007) H. Rietema et al.   EUROPEAN RESPIRATORY JOURNAL