Metabolic rewiring and redox alterations in malignant pleural mesothelioma

Epithelial to Mesenchymal Transition in Human Mesothelial Cells Exposed to Asbestos Fibers: Role of TGF-β as Mediator of Malignant Mesothelioma Development or Metastasis via EMT Event

(2019) Stefano Turini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

(2019) Vishal Das et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy

(2019) Raffit Hassan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy

(2019) Michele Carbone et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Empirical model of mesothelioma potency factors for different mineral fibers based on their chemical composition and dimensionality

(2019) Andrey Korchevskiy et al.   INHALATION TOXICOLOGY

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

(2019) Yang Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of reactive oxygen species via ERK and STAT3 dependent signalling are involved in the response of meso thelioma cells to exemestane

(2018) Barbara Nuvoli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials

(2018) Emanuela Felley-Bosco et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Selective killing of human T-ALL cells: an integrated approach targeting redox homeostasis and the OMA1/OPA1 axis

(2018) Micol Silic-Benussi et al.   Cell Death & Disease

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

(2018) Michele Carbone et al.   CELL DEATH AND DIFFERENTIATION

Paricalcitol attenuates TGF-β1–induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome

(2018) Jiyeon Ko et al.   FASEB JOURNAL

Iron addiction with ferroptosis-resistance in asbestos-induced mesothelial carcinogenesis: Toward the era of mesothelioma prevention

(2018) Shinya Toyokuni   FREE RADICAL BIOLOGY AND MEDICINE

Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes

(2018) Marta Betti et al.   GENES CHROMOSOMES & CANCER

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations

(2018) Sandra Pastorino et al.   JOURNAL OF CLINICAL ONCOLOGY

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

(2017) Marco Sciacovelli et al.   FEBS Journal

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells

(2017) Fintan Geoghegan et al.   Oncotarget

Folic acid phenotype (FAP) is a superior biomarker predicting response to pemetrexed-based chemotherapy in malignant pleural mesothelioma

(2017) Fabian Dominik Mairinger et al.   Oncotarget

Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function

(2017) Lucie Hebert et al.   Oncotarget

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma

(2017) Peter W. Szlosarek et al.   JAMA Oncology

Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity

(2016) David Larson et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

(2016) Konstantinos J. Mavrakis et al.   SCIENCE

MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

(2016) Gregory V. Kryukov et al.   SCIENCE

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

(2016) Katya Marjon et al.   Cell Reports

Where is iron in erionite? A multidisciplinary study on fibrous erionite-Na from Jersey (Nevada, USA)

(2016) Alessandro F. Gualtieri et al.   Scientific Reports

Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice

(2015) Ralph A. Pietrofesa et al.   CARCINOGENESIS

Malignant mesothelioma as an oxidative stress-induced cancer: An update

(2015) Shan Hwu Chew et al.   FREE RADICAL BIOLOGY AND MEDICINE

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species

(2015) MOTOYA TANAKA et al.   ONCOLOGY REPORTS

Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1

(2015) KI-EUN HWANG et al.   ONCOLOGY REPORTS

Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression

(2015) Jelena Krstić et al.   Oxidative Medicine and Cellular Longevity

Mesothelial cells in tissue repair and fibrosis

(2015) Steven E. Mutsaers et al.   Frontiers in Pharmacology

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma

(2015) Brian Cunniff et al.   PLoS One

Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma

(2015) Iza Denis et al.   Oncotarget

Sensitization of mesothelioma cells to platinum-based chemotherapy by GSTπ knockdown

(2014) Jianli Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival

(2014) Francine Baumann et al.   CARCINOGENESIS

Evaluation of clonal origin of malignant mesothelioma

(2014) Sabahattin Comertpay et al.   Journal of Translational Medicine

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Erionite induces production of autoantibodies and IL-17 in C57BL/6 mice

(2014) Christian Nash Zebedeo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deferasirox Induces Mesenchymal-Epithelial Transition in Crocidolite-Induced Mesothelial Carcinogenesis in Rats

(2013) H. Nagai et al.   Cancer Prevention Research

Targeting TGF-β signaling in cancer

(2013) Lior H Katz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The interaction of asbestos and iron in lung tissue revealed by synchrotron-based scanning X-ray microscopy

(2013) Lorella Pascolo et al.   Scientific Reports

Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells

(2012) Baiqing Tang et al.   CANCER BIOLOGY & THERAPY

Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma

(2012) Yoshie Yoshikawa et al.   CANCER SCIENCE

The real face of HIF1α in the tumor process

(2012) Matthias Kappler et al.   CELL CYCLE

Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma

(2012) Kyoichi Kaira et al.   EUROPEAN JOURNAL OF CANCER

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin

(2011) P. A. Zucali et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma

(2011) M. Carbone et al.   CLINICAL CANCER RESEARCH

Epithelial–mesenchymal transition in malignant mesothelioma

(2011) Ambrogio Fassina et al.   MODERN PATHOLOGY

Erionite exposure in North Dakota and Turkish villages with mesothelioma

(2011) M. Carbone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Versatility of PRMT5-induced methylation in growth control and development

(2011) Vrajesh Karkhanis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma

(2010) Sheelu Varghese et al.   CANCER

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imaging in pleural mesothelioma: A review of Imaging Research Presented at the 9th International Meeting of the International Mesothelioma Interest Group

(2010) Anna K. Nowak et al.   LUNG CANCER

Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells

(2010) Jedd M Hillegass et al.   Particle and Fibre Toxicology

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation

(2010) Haining Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor beta (TGF-β) and inflammation in cancer

(2009) Brian Bierie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

mTOR Mediates Survival Signals in Malignant Mesothelioma Grown as Tumor Fragment Spheroids

(2008) Shannon M. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanisms of ROS modulated cell survival during carcinogenesis

(2008) J.S. Clerkin et al.   CANCER LETTERS

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer

(2008) Hedy Lee Kindler et al.   INVESTIGATIONAL NEW DRUGS

NF-κB and epithelial to mesenchymal transition of cancer

(2008) Chengyin Min et al.   JOURNAL OF CELLULAR BIOCHEMISTRY