Sensitivity to asbestos is increased in patients with mesothelioma and pathogenic germline variants in BAP1 or other DNA repair genes

Analysis of the Exome Aggregation Consortium (ExAC) database suggests that the BAP1-t umor predisposition syndrome is underreported in cancer patients

(2018) James B. Massengill et al.   GENES CHROMOSOMES & CANCER

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

(2017) Elizabeth M Swisher et al.   LANCET ONCOLOGY

Integrative clinical genomics of metastatic cancer

(2017) Dan R. Robinson et al.   NATURE

Genotypic and Phenotypic Features of BAP1 Cancer Syndrome

(2017) Alexandra M. Haugh et al.   JAMA Dermatology

CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma

(2016) M. Betti et al.   CANCER LETTERS

The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations

(2016) S. Novello et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Germline BAP1 mutations misreported as somatic based on tumor-only testing

(2016) Mohamed H. Abdel-Rahman et al.   Familial Cancer

GermlineBAP1alterations in familial uveal melanoma

(2016) Karan Rai et al.   GENES CHROMOSOMES & CANCER

BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study

(2016) Luisella Righi et al.   Journal of Thoracic Oncology

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma

(2016) Joni A. Turunen et al.   OPHTHALMOLOGY

Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene–environment interaction

(2015) Mitchell Cheung et al.   CANCER LETTERS

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

(2015) Jill A. Ohar et al.   CANCER RESEARCH

Gene–asbestos interaction in malignant pleural mesothelioma susceptibility

(2015) Sara Tunesi et al.   CARCINOGENESIS

Comprehensive review ofBAP1tumor predisposition syndrome with report of two new cases

(2015) K. Rai et al.   CLINICAL GENETICS

Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma

(2015) Sophie Sneddon et al.   GENE

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

(2015) Sue Richards et al.   GENETICS IN MEDICINE

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer

(2015) Salima Daou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases

(2015) Andreas Rusch et al.   LUNG CANCER

BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations

(2015) Marta Cigognetti et al.   MODERN PATHOLOGY

Pleural mesothelioma and occupational and non-occupational asbestos exposure: a case-control study with quantitative risk assessment

(2015) Daniela Ferrante et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s

(2015) Michele Carbone et al.   PLoS Genetics

Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells

(2014) Milena Rondón-Lagos et al.   BMC CANCER

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

(2014) J. Xu et al.   CANCER RESEARCH

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

A recurrent germlineBAP1mutation and extension of theBAP1tumor predisposition spectrum to include basal cell carcinoma

(2014) K.A.W. Wadt et al.   CLINICAL GENETICS

Inference on germlineBAP1mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area

(2014) Marta Betti et al.   GENES CHROMOSOMES & CANCER

The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex

(2014) Zongling Ji et al.   NUCLEIC ACIDS RESEARCH

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

(2014) Giuseppe Matullo et al.   PLoS One

Numerical and Structural Genomic Aberrations Are Reliably Detectable in Tissue Microarrays of Formalin-Fixed Paraffin-Embedded Tumor Samples by Fluorescence In-Situ Hybridization

(2014) Heike Horn et al.   PLoS One

Germline BAP1 Mutations Predispose to Renal Cell Carcinomas

(2013) Tatiana Popova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Well-differentiated papillary mesothelioma: clustering in a Portuguese family with a germline BAP1 mutation

(2013) C. Ribeiro et al.   ANNALS OF ONCOLOGY

Expanding the clinical phenotype of hereditaryBAP1cancer predisposition syndrome, reporting three new cases

(2013) Robert Pilarski et al.   GENES CHROMOSOMES & CANCER

A genome-wide association study for malignant mesothelioma risk

(2013) Gemma Cadby et al.   LUNG CANCER

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Further evidence for germline BAP1 mutations predisposing to melanoma and malignant mesothelioma

(2013) Mitchell Cheung et al.   Cancer Genetics

Toward an Improved Definition of the Tumor Spectrum Associated WithBAP1Germline Mutations

(2012) Thomas Wiesner et al.   JOURNAL OF CLINICAL ONCOLOGY

BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs

(2012) Michele Carbone et al.   Journal of Translational Medicine

A crypticBAP1splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma

(2012) Karin Wadt et al.   Pigment Cell & Melanoma Research

Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers

(2011) M. H. Abdel-Rahman et al.   JOURNAL OF MEDICAL GENETICS

Germline mutations in BAP1 predispose to melanocytic tumors

(2011) Thomas Wiesner et al.   NATURE GENETICS

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases

(2008) M NERI et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH