The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)

Hypoxia and cellular metabolism in tumour pathophysiology

(2017) Scott K. Parks et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth

(2016) Y. Cormerais et al.   CANCER RESEARCH

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells

(2016) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export

(2016) Scott K. Parks et al.   MOLECULAR ASPECTS OF MEDICINE

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

(2016) Oliver D.K. Maddocks et al.   MOLECULAR CELL

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation

(2015) Katherine Sellers et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Amino acid management in cancer

(2015) Zhi-Yang Tsun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

(2014) C Rosilio et al.   LEUKEMIA

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia

(2013) L. Willems et al.   BLOOD

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Nutrient transporters: the Achilles’ heel of anabolism

(2013) Alison N. McCracken et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

(2012) M. Hassanein et al.   CLINICAL CANCER RESEARCH

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

(2012) KEITARO HAYASHI et al.   ONCOLOGY REPORTS

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I–III nonsmall cell lung cancer

(2008) K Kaira et al.   BRITISH JOURNAL OF CANCER

Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling

(2008) N M Reddy et al.   ONCOGENE

L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer

(2008) Takeshi Sakata et al.   PATHOLOGY INTERNATIONAL

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA