Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells

(2014) S M Cheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer treatment and survivorship statistics, 2014

(2014) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Combination of YM155, a Survivin Suppressant, with Bendamustine and Rituximab: A New Combination Therapy to Treat Relapsed/Refractory Diffuse Large B-cell Lymphoma

(2014) N. Kaneko et al.   CLINICAL CANCER RESEARCH

Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma

(2013) Yu-Fan Wang et al.   APOPTOSIS

Synergistic Antitumor Activities of Sepantronium Bromide (YM155), a Survivin Suppressant, in Combination with Microtubule-Targeting Agents in Triple-Negative Breast Cancer Cells

(2013) Naoki Kaneko et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

(2013) Lu Zhang et al.   CANCER LETTERS

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

The Role of Calcium Stores in Apoptosis and Autophagy

(2013) S. S. Smaili et al.   CURRENT MOLECULAR MEDICINE

YM155 sensitizes ovarian cancer cells to cisplatin inducing apoptosis and tumor regression

(2013) Roser Mir et al.   GYNECOLOGIC ONCOLOGY

Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma

(2013) Florian Ewald et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of pluripotent stem cell-derived teratoma formation by small molecules

(2013) M.-O. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting survivin in cancer

(2012) Dario C. Altieri   CANCER LETTERS

A Phase II Study of Lapatinib in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

(2012) J. A. de Souza et al.   CLINICAL CANCER RESEARCH

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

Epigenetic and genetic alterations-based molecular classification of head and neck cancer

(2012) Zhien Feng et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

The molecular pathogenesis of head and neck squamous cell carcinoma

(2012) S. Michael Rothenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

A phase II study of YM155, a novel small-molecule suppressor of survivin, in castration-resistant taxane-pretreated prostate cancer

(2011) A. W. Tolcher et al.   ANNALS OF ONCOLOGY

YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model

(2011) Takahito Nakahara et al.   ANTI-CANCER DRUGS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells

(2011) Qinwen Wang et al.   CANCER LETTERS

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

(2011) Kentaro Yamanaka et al.   CLINICAL CANCER RESEARCH

Utility of P-Glycoprotein and Organic Cation Transporter 1 Double-Transfected LLC-PK1 Cells for Studying the Interaction of YM155 Monobromide, Novel Small-Molecule Survivin Suppressant, with P-Glycoprotein

(2011) M. Iwai et al.   DRUG METABOLISM AND DISPOSITION

Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP3 signaling pathway

(2011) Yi Zhao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma

(2011) Aya Kita et al.   LEUKEMIA RESEARCH

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin

(2010) Zhi-Jun Sun et al.   APOPTOSIS

Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models

(2010) Takahito Nakahara et al.   CANCER SCIENCE

Cetuximab-Based Immunotherapy and Radioimmunotherapy of Head and Neck Squamous Cell Carcinoma

(2010) G. Niu et al.   CLINICAL CANCER RESEARCH

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

(2010) Ting-Kuang Niu et al.   FEBS LETTERS

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Mammalian Target of Rapamycin Pathway Promotes Tumor-Induced Angiogenesis in Adenoid Cystic Carcinoma: Its Suppression by Isoliquiritigenin through Dual Activation of c-Jun NH2-Terminal Kinase and Inhibition of Extracellular Signal-Regulated Kinase

(2010) Z.-J. Sun et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Curcumin Dually Inhibits Both Mammalian Target of Rapamycin and Nuclear Factor- B Pathways through a Crossed Phosphatidylinositol 3-Kinase/Akt/I B Kinase Complex Signaling Axis in Adenoid Cystic Carcinoma

(2010) Z.-J. Sun et al.   MOLECULAR PHARMACOLOGY

Progressive Tumor Formation in Mice with Conditional Deletion of TGF-  Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway

(2009) Y. Bian et al.   CANCER RESEARCH

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global epidemiology of oral and oropharyngeal cancer

(2008) Saman Warnakulasuriya   ORAL ONCOLOGY