Article
Neurosciences
Banashree Chetia Phukan, Ankumoni Dutta, Satarupa Deb, Rubul Saikia, Muhammed Khairujjaman Mazumder, Rajib Paul, Pallab Bhattacharya, Rajat Sandhir, Anupom Borah
Summary: The study suggests that Garcinol may provide neuroprotection and alleviate motor behavioral deficits in PD mice, while preventing the loss of dopaminergic neurons.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Beatriz Thomasi, Luisa Valdetaro, Brian Gulbransen, Ana Lucia Tavares-Gomes
Summary: The gastrointestinal tract, as the largest immune organ, plays a crucial role in the pathogenesis of diseases such as Parkinson's disease by interacting with the neural systems.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Martina Montanari, Paola Imbriani, Paola Bonsi, Giuseppina Martella, Antonella Peppe
Summary: The enteric nervous system (ENS), composed of neurons and glial cells, regulates the motor and secretory functions of the gastrointestinal tract. Dysfunction of the connections between the brain and the GI tract is implicated in Parkinson's disease (PD). Alterations in the ENS, including α-synuclein aggregation, occur early in the disease and spread to the central nervous system. This review highlights the role of the ENS in PD pathogenesis and its potential as a target for new therapeutic approaches.
Article
Multidisciplinary Sciences
Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Summary: The authors report epigenetic disruption of autophagy-lysosome pathway (ALP) related genes in the appendix of individuals with Parkinson's disease, suggesting a potential mechanism for accumulation of alpha-synuclein pathology in idiopathic PD. This disruption of ALP genes in the appendix may contribute to the aggregation of alpha-synuclein and alpha-synuclein pathology seen in PD patients.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Yueshan Pang, Juan Xiong, You Wu, Weijun Ding
Summary: Nobiletin, a compound with high fat solubility, high bioavailability, and low toxicity, has been extensively studied for its various biological functions in the nervous system. It has shown positive effects in inhibiting inflammatory factor expression, promoting nerve cell survival and axon growth. Additionally, nobiletin has been found to protect the enteric nervous system, spinal cord, and sciatic nerve.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Lee
Summary: The present study found that a diet containing morin can prevent motor dysfunction and dopaminergic neuronal damage in a mouse model of Parkinson's disease. It can also significantly reduce neuroinflammation. In vitro studies showed that morin exerts its anti-inflammatory effects by blocking the ERK-p65 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
J. Brucker Nourse, Shannon N. Russell, Nathan A. Moniz, Kylie Peter, Lena M. Seyfarth, Madison Scott, Han-A Park, Kim A. Caldwell, Guy A. Caldwell
Summary: This study investigates the TNK2 gene variants in Parkinson's disease (PD) patients and their potential impact on dopaminergic neurodegeneration. The findings suggest that TNK2 dysfunction may contribute to PD, possibly through sustained or aberrant activity. The study also highlights the importance of TNK2 and its ortholog SID-3 in coordinating dopaminergic and epigenetic signaling. Experimental results using Caenorhabditis elegans and rat primary neurons demonstrate the neuroprotective effects of TNK2 inhibition and NEDD4 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Nutrition & Dietetics
Patricia Pereira Almeida, Ana Lucia Tavares-Gomes, Milena Barcza Stockler-Pinto
Summary: The enteric nervous system (ENS) regulates functions and immune processes in the gastrointestinal tract. Diseases can disrupt ENS functionality by increasing reactive oxygen species accumulation, impacting enteric neurons and glial cells. Nutritional strategies aimed at reducing reactive oxygen species production can modulate the ENS, and studies have shown that nutrients with antioxidant roles have potential in this regard.
Article
Biochemistry & Molecular Biology
Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Seong-Eun Kim, Hee-Sun Kim
Summary: This study investigated the neuroprotective effects of NKT in a Parkinson's disease mouse model. The results showed that NKT restored motor impairment and dopaminergic neuronal loss, increased the expression of neurotrophic factors, and inhibited inflammation and oxidative stress. Additionally, the study found that NKT acted through astrocytic Nrf2 and its downstream antioxidant molecules.
Review
Endocrinology & Metabolism
Bilal Haider Shamsi, Mahanand Chatoo, Xiao Kang Xu, Xun Xu, Xue Qun Chen
Summary: Somatostatin (SST) and somatostatin receptors (SSTRs) are crucial in the brain and gastrointestinal system, regulating various physiological functions and playing a role in cancer treatment. Understanding their functions in the endocrine and neuroendocrine systems in the gastrointestinal tract is essential for advanced medicine in basic and clinical research.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Heyu Zhu, Yuanmei Yan, Yi Jiang, Xianfang Meng
Summary: This article reviews the biochemical functions and neuroprotective effects of ellagic acid (EA), demonstrating its clinical value and potential therapeutic benefits for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Marine Mantel, Pascal Derkinderen, Kalyane Bach-Ngohou, Michel Neunlist, Malvyne Rolli-Derkinderen
Summary: The enteric nervous system (ENS) is able to integrate signals to accurately regulate digestive functions. The ENS produces n-6 oxylipins, derived from arachidonic acid, which play a major role in various physiological processes. The study of these oxylipins on digestive functions and their interaction with the ENS is expanding.
FRONTIERS IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ankumoni Dutta, Banashree Chetia Phukan, Rubina Roy, Muhammed Khairujjaman Mazumder, Rajib Paul, Amarendranath Choudhury, Diwakar Kumar, Pallab Bhattacharya, Joyobrato Nath, Sanjeev Kumar, Anupom Borah
Summary: The study found that G. morella fruit extract has dopaminergic neuroprotective effects in a mouse model of Parkinson's disease. It achieves this by restoring mitochondrial function and inhibiting neuroinflammation, resulting in the reversal of pathological and behavioral abnormalities.
METABOLIC BRAIN DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Tinh Thi Nguyen, Peter Baumann, Oliver Tuescher, Sandra Schick, Kristina Endres
Summary: The gut and the brain communicate through various channels and interactions, collectively known as the gut-brain axis. The aging of the enteric nervous system (ENS) in the gut can lead to gastrointestinal dysfunction and contribute to age-related diseases of the brain. Understanding the mechanisms of the aging ENS can provide insights into the diagnosis and treatment of neurodegenerative diseases like Alzheimer's and Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Imene Melki, Isabelle Allaeys, Nicolas Tessandier, Tania Levesque, Nathalie Cloutier, Audree Laroche, Nathalie Vernoux, Yann Becker, Hadrien Benk-Fortin, Anne Zufferey, Emmanuelle Rollet-Labelle, Marc Pouliot, Guy Poirier, Natacha Patey, Clemence Belleannee, Denis Soulet, Steven E. McKenzie, Alain Brisson, Marie-Eve Tremblay, Christian Lood, Paul R. Fortin, Eric Boilard
Summary: The study reveals that platelets release mitochondrial DNA in patients with SLE, and this process is associated with platelet degranulation and requires stimulation of platelet Fc-γ-RIIA.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Amandine Isenbrandt, Marc Morissette, Melanie Bourque, Jerome Lamontagne-Proulx, Katherine Coulombe, Denis Soulet, Therese Di Paolo
Summary: The study examined the effects of sex hormones on a mouse model of Parkinson's disease and the neuroprotective role of the 5 alpha-reductase inhibitor dutasteride. Results showed sex differences in mice MPTP toxicity and response to dutasteride, with implications of neuroinflammation.
Article
Nutrition & Dietetics
Jerome Lamontagne-Proulx, Katherine Coulombe, Fadil Dahhani, Melissa Cote, Cedric Guyaz, Cyntia Tremblay, Vincenzo Di Marzo, Nicolas Flamand, Frederic Calon, Denis Soulet
Summary: The study demonstrates that dietary supplementation with DHA can protect enteric DAergic neurons in Thy1-alpha Syn mice, decrease microgliosis in the striatum, and promote the accumulation of eCB-like mediators, GLP-1, and Nrf2 in the ENS.
Article
Cell Biology
Marc Morissette, Melanie Bourque, Marie-Eve Tremblay, Therese Di Paolo
Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Article
Biochemical Research Methods
Valerie Brousseau, Patrick Caron, Jocelyn Trottier, Therese Di Paolo, Piotr Milkiewicz, Olivier Barbier
Summary: This study developed a method for quantification of 24S-hydroxycholesterol and its derivatives in human plasma and validated its clinical applications. The results indicate the accumulation of cerebrosterol and its conjugates in the plasma of cholestatic patients.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Biochemistry & Molecular Biology
Morgan Berard, Razan Sheta, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Sales, Jerome Lamontagne-Proulx, Marie-Kim St-Pierre, Omid Tavassoly, Wen M. Luo, Esther Del Cid-Pellitero, Raza Qazi, Jae-Woong Jeong, Thomas Durcan, Luc Vallieres, Marie-Eve A. Tremblay, Denis Soulet, Martin Levesque, Francesca Cicchetti, Edward Fon, Armen Saghatelyan, Abid Oueslati
Summary: Neurodegenerative disorders are associated with abnormal protein accumulation and aggregation in the central nervous system. This study developed a light-inducible protein aggregation system that allows for the control and investigation of alpha-synuclein aggregation in Parkinson disease. The findings demonstrate that this system mimics key features of authentic Lewy bodies and induces neurodegeneration and motor impairments in vivo.
Article
Cell Biology
Tara Smith, Kaeli J. Knudsen, Shawn A. Ritchie
Summary: This study evaluated the pharmacokinetics, mass balance, and tissue distribution of PPI-1011, a synthetic plasmalogen precursor, in Sprague-Dawley rats. The results showed that oral administration of PPI-1011 resulted in high uptake across the body, including the brain. Repeated dosing increased the uptake, suggesting that it could be a viable therapeutic strategy for treating plasmalogen deficiencies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Andree-Anne Poirier, Melissa Cote, Hend Jarras, Nadhir Litim, Jerome Lamontagne-Proulx, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Martin Pelletier, Therese Di Paolo, Denis Soulet
Summary: This study demonstrates that dutasteride can prevent enteric neuronal damage in the MPTP mouse model of Parkinson's disease by anti-inflammatory and mitochondrial effects, suggesting that drug repurposing of dutasteride might be a promising avenue to treat enteric neuroinflammation in early PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Andree-Anne Poirier, Melanie Cote, Melanie Bourque, Hend Jarras, Jerome Lamontagne-Proulx, Marc Morissette, Therese Di Paolo, Denis Soulet
Summary: Estrogens have beneficial effects in Parkinson's disease, mainly through activation of the GPER1 receptor. Targeting GPER1 could be a promising approach for future estrogen-based hormone therapies in early PD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Cell Biology
Melanie Bourque, Laurent Gregoire, Waseema Patel, David Dickens, Ralph Snodgrass, Therese Di Paolo
Summary: N-methyl-D-aspartate (NMDA) receptors have been implicated in L-Dopa-induced dyskinesias (LID) in Parkinson's disease patients. L-4-chlorokynurenine (AV-101) is a pro-drug of 7-chlorokynurenic acid, a specific antagonist of the glycine co-agonist site of NMDA receptors. This study investigated the effects of AV-101 on LID in MPTP-lesioned monkeys and found that it reduced LID and maintained the antiparkinsonian activity of L-Dopa. AV-101 showed comparable antidyskinetic activity to amantadine but without adverse effects.
Article
Chemistry, Medicinal
Amandine Isenbrandt, Katherine Coulombe, Marc Morissette, Melanie Bourque, Jerome Lamontagne-Proulx, Therese Di Paolo, Denis Soulet
Summary: Parkinson's disease is characterized by neurodegeneration and neuroinflammation. The modulation of gonadal hormones may have an impact on the disease course. In this study, male and female mice were investigated to determine the effects of gonadal hormones on Parkinson's disease. It was found that a 5 alpha-reductase inhibitor, DUT, could protect against the toxic effects of the disease.
Article
Biochemistry & Molecular Biology
Jerome Lamontagne-Proulx, Katherine Coulombe, Marc Morissette, Marie Rieux, Frederic Calon, Therese Di Paolo, Denis Soulet
Summary: The mutation and overexpression of alpha-synuclein protein is associated with Parkinson's disease. The prevalence of PD is higher in men than in women, suggesting the involvement of female hormones in slowing PD progression. In mice, male individuals are more vulnerable to toxins and exhibit more severe toxicity from alpha-synuclein protein than females.
Article
Neurosciences
Melanie Bourque, Marc Morissette, Denis Soulet, Therese Di Paolo
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Gender differences and sex hormones play a role in the neuroimmune contributions to PD. Both PD patients and animal models show neuroinflammation and immune differences between males and females.
BRAIN RESEARCH BULLETIN
(2023)
Article
Hematology
Audree Laroche, Denis Soulet, Marc Bazin, Tania Levesque, Isabelle Allaeys, Nicolas Vallieres, Matthias Gunzer, Louis Flamand, Steve Lacroix, Eric Boilard
Summary: This study describes the cellular events that occur in the brain vasculature in response to the systemic administration of immune complexes, using real-time videomicroscopy and computer-assisted analysis. The authors observed interactions between platelets and neutrophils, platelet thrombus formation, and neutrophil adhesion to blood vessel walls. These findings provide valuable insight into the pathogenic roles of immune complexes in disease.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.