Novel antithrombotic strategies for treatment of venous thromboembolism

E-Selectin Inhibition: A New Way to Treat Proximal Deep Venous Thrombosis

(2019) Daniel Myers et al.   Journal of Vascular Surgery-Venous and Lymphatic Disorders

MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

(2019) Alexander W. Koch et al.   BLOOD

AB023, A Novel Antibody That Binds Factor XI and Blocks Its Activation by Factor XIIa

(2019) Noel C. Chan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

(2019) Christina U. Lorentz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism

(2018) Tyree H. Kiser et al.   CRITICAL CARE MEDICINE

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

(2018) Helen Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comparison of an Oral Factor Xa Inhibitor With Low Molecular Weight Heparin in Patients With Cancer With Venous Thromboembolism: Results of a Randomized Trial (SELECT-D)

(2018) Annie M. Young et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: guidance from the SSC of the ISTH

(2018) A. A. Khorana et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolysis: strategies to enhance the treatment of acute ischemic stroke

(2018) S. J. Henderson et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism

(2018) Gary E. Raskob et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation and characterization of monoclonal antibodies against the N-terminus of alpha-2-antiplasmin

(2018) Shiraazkhan Abdul et al.   PLoS One

Direct oral anticoagulant (DOAC) versus low-molecular-weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis

(2018) Ang Li et al.   THROMBOSIS RESEARCH

Advances in Antithrombotic Therapy

(2018) Jeffrey I. Weitz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

(2018) Jingxuan Liu et al.   RNA

A first-in-human study of DS-1040, an inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor, in healthy subjects

(2017) J. Zhou et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis

(2017) Suresh Vedantham et al.   NEW ENGLAND JOURNAL OF MEDICINE

E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model

(2017) Dorian Culmer et al.   THROMBOSIS AND HAEMOSTASIS

Generation and characterization of aptamers targeting factor XIa

(2017) R.S. Woodruff et al.   THROMBOSIS RESEARCH

The role of leukocytes in thrombosis

(2016) Laura L. Swystun et al.   BLOOD

Antithrombotic Therapy for VTE Disease

(2016) Clive Kearon et al.   CHEST

Evolving Treatments for Arterial and Venous Thrombosis

(2016) Noel C. Chan et al.   CIRCULATION RESEARCH

Reduced fibrinolytic resistance in patients with factor XI deficiency. Evidence of a thrombin-independent impairment of the thrombin-activatable fibrinolysis inhibitor pathway

(2016) M. Colucci et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Factor XI and factor XII as targets for new anticoagulants

(2016) Jeffrey I. Weitz   THROMBOSIS RESEARCH

The role of thrombolytic therapy in pulmonary embolism

(2015) T.-F. Wang et al.   BLOOD

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve‐Induced Thrombin Generation

(2015) Iqbal H. Jaffer et al.   Journal of the American Heart Association

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

(2014) A. Matafonov et al.   BLOOD

Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials

(2014) N. van Es et al.   BLOOD

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

(2014) Jonathan W. Yau et al.   BLOOD

Thrombolysis for Pulmonary Embolism and Risk of All-Cause Mortality, Major Bleeding, and Intracranial Hemorrhage

(2014) Saurav Chatterjee et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Fibrinolysis for Patients with Intermediate-Risk Pulmonary Embolism

(2014) Guy Meyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Considerations for Assessment of Reproductive and Developmental Toxicity of Oligonucleotide-Based Therapeutics

(2014) Joy Cavagnaro et al.   Nucleic Acid Therapeutics

Epidemiologic and clinical data linking factors XI and XII to thrombosis

(2014) N. S. Key   Hematology-American Society of Hematology Education Program

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

(2013) Jeffrey R. Crosby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer

(2013) R. S. Woodruff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial

(2013) Susan R Kahn et al.   LANCET

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

(2013) John W. Eikelboom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anticoagulation beyond direct thrombin and factor Xa inhibitors: indications for targeting the intrinsic pathway?

(2013) Maurits van Montfoort et al.   THROMBOSIS AND HAEMOSTASIS

Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo

(2012) Jonathan W. Yau et al.   Acta Biomaterialia

Moderate Pulmonary Embolism Treated With Thrombolysis (from the “MOPETT” Trial)

(2012) Mohsen Sharifi et al.   AMERICAN JOURNAL OF CARDIOLOGY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

(2012) Philberta Y. Leung et al.   Translational Stroke Research

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial

(2011) Tone Enden et al.   LANCET

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

(2010) H. Zhang et al.   BLOOD

Management of Submassive Pulmonary Embolism

(2010) Gregory Piazza et al.   CIRCULATION

How I treat postthrombotic syndrome

(2009) S. R. Kahn   BLOOD

Post-thrombotic syndrome: prevalence, prognostication and need for progress

(2009) Paolo Prandoni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Prospective Evaluation of Right Ventricular Function and Functional Status 6 Months After Acute Submassive Pulmonary Embolism

(2009) Jeffrey A. Kline et al.   CHEST

Factor XI deficiency in animal models

(2009) T. RENNÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

P-selectin/ PSGL-1 Inhibitors versus enoxaparin in the resolution of venous thrombosis: A meta-analysis

(2009) Eduardo Ramacciotti et al.   THROMBOSIS RESEARCH

Mechanisms of Venous Thrombosis and Resolution

(2008) Thomas W. Wakefield et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The vessel wall and its interactions

(2008) D. D. Wagner et al.   BLOOD

Evidence that α2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation

(2008) M. W. MOSESSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS