An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

Factor XII and uPAR upregulate neutrophil functions to influence wound healing

(2018) Evi X. Stavrou et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis

(2017) Aleena Banerji et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

(2017) K. John Pasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

(2017) Kevin Fitzgerald et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations

(2016) Steven de Maat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII

(2016) D. Zamolodchikov et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Kininogen Cleavage Assay: Diagnostic Assistance for Kinin-Mediated Angioedema Conditions

(2016) Rémi Baroso et al.   PLoS One

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

F12-46C/T polymorphism as modifier of the clinical phenotype of hereditary angioedema

(2015) M. Speletas et al.   ALLERGY

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

(2015) Jenny Björkqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Factor XII: a novel target for safe prevention of thrombosis and inflammation

(2015) E. Kenne et al.   JOURNAL OF INTERNAL MEDICINE

Inhibition of Vascular Permeability by Antisense-Mediated Inhibition of Plasma Kallikrein and Coagulation Factor 12

(2015) Gourab Bhattacharjee et al.   Nucleic Acid Therapeutics

Current update on cellular and molecular mechanisms of hereditary angioedema

(2014) Hannah H. Walford et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

(2014) A. Matafonov et al.   BLOOD

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo activation and functions of the protease factor XII

(2014) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Hereditary Angioedema with Normal C1 Inhibitor

(2013) Konrad Bork   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Summary and Conclusions: New Perspectives in Hereditary Angioedema: Molecular Mechanisms and Therapeutic Choices: A CME Symposium Presented at the World Allergy Congress, Buenos Aires, Argentina (December 2009)

(2013) Bruce L Zuraw   World Allergy Organization Journal

Less severe clinical manifestations in patients with hereditary angioedema with missense C1INH gene mutations

(2012) Andras Bors et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathophysiology of Hereditary Angioedema

(2011) Bruce L. Zuraw et al.   American Journal of Rhinology & Allergy

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Hereditary angioedema caused by missense mutations in the factor XII gene: Clinical features, trigger factors, and therapy

(2009) Konrad Bork et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY