MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects

(2018) Vidya Perera et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Incorporating Comprehensive Management of Direct Oral Anticoagulants into Anticoagulation Clinics

(2017) Insaf Mohammad et al.   PHARMACOTHERAPY

Factor XI deficiency is associated with lower risk for cardiovascular and venous thromboembolism events

(2016) Meir Preis et al.   BLOOD

Global Burden of Thrombosis: Table.

(2016) Aaron M. Wendelboe et al.   CIRCULATION RESEARCH

Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis

(2016) Tovo David et al.   Science Translational Medicine

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Factor XI as a target for antithrombotic therapy

(2014) Charles E. Bane et al.   DRUG DISCOVERY TODAY

Dabigatran, bleeding, and the regulators

(2014) T. J. Moore et al.   BMJ-British Medical Journal

Correlation of Missed Doses of Enoxaparin With Increased Incidence of Deep Vein Thrombosis in Trauma and General Surgery Patients

(2014) Scott G. Louis et al.   JAMA Surgery

Congenital Factor XI Deficiency: An Update

(2013) Stefano Duga et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Relation of the HAS-BLED Bleeding Risk Score to Major Bleeding, Cardiovascular Events, and Mortality in Anticoagulated Patients With Atrial Fibrillation

(2012) Pilar Gallego et al.   Circulation-Arrhythmia and Electrophysiology

Monitoring low dose recombinant factor VIIa therapy in patients with severe factor XI deficiency undergoing surgery

(2011) Anne Riddell et al.   THROMBOSIS AND HAEMOSTASIS

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Structure and function of factor XI

(2010) J. Emsley et al.   BLOOD

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

(2010) Ophira Salomon et al.   THROMBOSIS AND HAEMOSTASIS

Reduced incidence of ischemic stroke in patients with severe factor XI deficiency

(2008) O. Salomon et al.   BLOOD