Article
Agriculture, Dairy & Animal Science
Sarah R. McCoski, Rebecca R. Cockrum, Alan D. Ealy
Summary: Exposure to maternal obesity during pregnancy can have significant effects on offspring development, which may not be apparent until adulthood. This study investigated how obesity influences gene expression in the endometrium during early pregnancy using a sheep model. The results showed that obesity affects gene expression related to the immune response, adhesion, and angiogenesis in the endometrium. These findings suggest that the peri-implantation endometrium is responsive to maternal obesity and changes in gene expression during early embryogenesis may contribute to developmental programming.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Obstetrics & Gynecology
Awoniyi O. Awonuga, Olivia G. Camp, Husam M. Abu-Soud, Daniel A. Rappolee, Elizabeth E. Puscheck, Michael P. Diamond
Summary: The contributions of uterine endometrium and embryo in implantation success are still debated. Various measures, such as endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures, are recommended to improve implantation success. However, there is insufficient evidence to determine the relative importance of endometrium and embryo in implantation success and the utility of these measures, especially with euploid embryos. Evidence suggests that embryos can implant and develop on non-endometrium epithelium. The role of embryo euploidy in implantation success is currently underappreciated.
REPRODUCTIVE SCIENCES
(2023)
Article
Reproductive Biology
Mehmet Kose, Mustafa Hitit, Mehmet Salih Kaya, Mesut Kirbas, Sukru Dursun, Ilyas Alak, Mehmet Osman Atli
Summary: This study aimed to elucidate the expression pattern of miRNAs in the endometrium during peri-implantation in ewes. A total of 116 ovine-specific miRNAs were detected, with 19 differentially expressed in early pregnancy. The differentially expressed miRNAs targeted a total of 315 genes, with functional enrichment in the innate immune system and signaling pathways.
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Yuta Matsuno, Kazuya Kusama, Kazuhiko Imakawa
Summary: This study characterized the expression profile of lncRNAs during peri-implantation periods in sheep conceptuses. The analysis identified a total of 8808 lncRNAs, including 3423 novel lncRNAs. Gene ontology analysis revealed enrichment of lncRNA target genes in the respiratory electron transport chain (RETC). The findings suggest that lncRNAs may play a role in regulating RETC during conceptus development in sheep.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Qi Zhu, Simin Yao, Yishan Dong, Dan Liu, Huiyan Wang, Peipei Jiang, Chenyan Dai, Haining Lv, Chenrui Cao, Zhenhua Zhou, Limin Wang, Wenjing Gou, Xiwen Zhang, Guangfeng Zhao, Yali Hu
Summary: The study found that genes related to cell division and cycle were inhibited, while inflammation and oxidative stress increased in thin endometrium patients. The decreased expression of PBK in HESCs affected cell proliferation and apoptosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Davoud Jafari-Gharabaghlou, Mostafa Vaghari-Tabari, Hajar Oghbaei, Laura Lotz, Reza Zarezadeh, Yeganeh Rastgar Rezaei, Mahnaz Ranjkesh, Mohammad Nouri, Amir Fattahi, Saba Nikanfar, Ralf Dittrich
Summary: This review highlights the role of various adipokines in embryo-maternal interactions, endometrial receptivity, and embryo implantation, as well as the underlying molecular mechanisms.
ENDOCRINE CONNECTIONS
(2021)
Review
Immunology
Sylvie Bouvier, Elise Kaspi, Ahmad Joshkon, Odile Paulmyer-Lacroix, Marie-Dominique Piercecchi-Marti, Akshita Sharma, Aurelie S. Leroyer, Alexandrine Bertaud, Jean-Christophe Gris, Francoise Dignat-George, Marcel Blot-Chabaud, Nathalie Bardin
Summary: CD146 acts as an adhesion molecule in the vascular system and has been shown to play a key role in angiogenesis. Studies suggest that the soluble form of CD146, sCD146, regulates migration and invasion of extravillous trophoblasts. Measurement of sCD146 in plasma can be used to predict pregnancy complications such as preeclampsia or implantation defects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Rong Li, Xiaoqiu Wang, Zhenyao Huang, Jayani Balaji, Tae Hoon Kim, Tianyuan Wang, Lecong Zhou, Ashley Deleon, Molly E. Cook, Margeaux W. Marbrey, San-Pin Wu, Jae Wook Jeong, Ripla Arora, Francesco J. DeMayo
Summary: The loss of uterine epithelial progesterone receptor (PGR) is crucial for embryo implantation in both humans and mice. This study reveals that the two major isoforms PGRA and PGRB disrupt embryo implantation through FOXO1 pathways in uterine epithelium, and both regulate the LIF-SGK1-FOXO1 signaling pathway.
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Ryan M. Brown, Linda Wang, Anqi Fu, Athilakshmi Kannan, Michael Mussar, Indrani C. Bagchi, Joan S. Jorgensen
Summary: Irx3 promotes successful embryo-uterine interactions in mice.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biology
Jinxiang Wu, Shu Lin, Pinxiu Huang, Lingling Qiu, Yufei Jiang, Ying Zhang, Nan Meng, Meiqing Meng, Lemeng Wang, Wenbo Deng, Zhao Liu, Chuanhui Guo, Jinhua Lu, Haibin Wang, Shuangbo Kong
Summary: Experiments on mice and analysis of human samples suggest that mental stress during early pregnancy can alter the functional status of endometrial receptivity, potentially leading to pregnancy failure. The epinephrine signaling pathway is found to play a significant role in regulating endometrial receptivity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Wiktoria Kozlowska, Ewa Monika Drzewiecka, Agata Zmijewska, Anna Koziorowska, Anita Franczak
Summary: This study investigated the effects of EMF on androgen synthesis and release from pig endometrium, finding that EMF may have suppressive effects on endometrial testosterone release and increased androstenedione release. Progesterone did not protect the pig endometrium against EMF radiation during the fetal peri-implantation period.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Satish Agrawal, Monika Dwivedi, Hafsa Ahmad, Sangappa Basanna Chadchan, Abhishek Arya, Roshan Sikandar, Shweta Kaushik, Kalyan Mitra, Rajesh Kumar, Anil Kumar Dwivedi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Reproductive Biology
Upendra Kumar Soni, Sangappa Basanna Chadchan, Vijay Kumar, Vaibhave Ubba, Mohammad Tariq Ali Khan, Budai Shanmukha Vivek Vinod, Rituraj Konwar, Himangsu Kousik Bora, Srikanta Kumar Rath, Sharad Sharma, Rajesh Kumar Jha
BIOLOGY OF REPRODUCTION
(2019)
Article
Obstetrics & Gynecology
Sangappa B. Chadchan, Meng Cheng, Lindsay A. Parnell, Yin Yin, Andrew Schriefer, Indira U. Mysorekar, Ramakrishna Kommagani
HUMAN REPRODUCTION
(2019)
Article
Endocrinology & Metabolism
Arin K. Oestreich, Sangappa B. Chadchan, Pooja Popli, Alexandra Medvedeva, Marina N. Rowen, Claire S. Stephens, Ran Xu, John P. Lydon, Francesco J. Demayo, Emily S. Jungheim, Kelle H. Moley, Ramakrishna Kommagani
Article
Cell Biology
Upendra Kumar Soni, Sangappa Basanna Chadchan, Anubha Joshi, Vijay Kumar, Vineet Kumar Maurya, Raj Kumar Verma, Rajesh Kumar Jha
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Cell Biology
Sangappa B. Chadchan, Vineet K. Maurya, Gwendalyn L. Krekeler, Emily S. Jungheim, Ramakrishna Kommagani
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Pooja Popli, Megan M. Richters, Sangappa B. Chadchan, Tae Hoon Kim, Eric Tycksen, Obi Griffith, Premal H. Thaker, Malachi Griffith, Ramakrishna Kommagani
CELL DEATH & DISEASE
(2020)
Article
Reproductive Biology
Sangappa B. Chadchan, Pooja Popli, Vineet K. Maurya, Ramakrishna Kommagani
Summary: ACE2 protein expression in the endometrium varies during the menstrual cycle and plays a crucial role in uterine physiology. This suggests that SARS-CoV-2 may affect endometrial stromal cells and potentially lead to pathological manifestations in women with COVID-19.
BIOLOGY OF REPRODUCTION
(2021)
Article
Developmental Biology
Upendra Kumar Soni, Sangappa Basanna Chadchan, Rakesh Kumar Gupta, Vijay Kumar, Rajesh Kumar Jha
Summary: miR-149 plays a crucial role in regulating endometrial receptivity and decidualization for trophoblast implantation by targeting PARP-2 and caspase-8 proteins in endometrial cells.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Raj Kumar Verma, Upendra Kumar Soni, Sangappa Basanna Chadchan, Vineet Kumar Maurya, Mohini Soni, Sudarsan Sarkar, J. Venkatesh Pratap, Rajesh Kumar Jha
Summary: E-cadherin is predominantly expressed during the pre-receptive stage of endometrial receptivity and is promoted by PARP-2, which is regulated by miR-149. On the other hand, N-cadherin is only detected at the early stages and decreases thereafter.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma
Summary: Functional retinoic acid (RA) signaling is crucial for female fertility, especially implantation and decidualization, as shown by genetic mouse models and human endometrial stromal cell studies. Disruption of uterine RA signaling leads to compromised fertility due to failure of uterine receptivity and decidualization.
Article
Biology
Sangappa B. Chadchan, Pooja Popli, Chandrasekhar R. Ambati, Eric Tycksen, Sang Jun Han, Serdar E. Bulun, Nagireddy Putluri, Scott W. Biest, Ramakrishna Kommagani
Summary: Endometriosis is a painful disease affecting millions worldwide, with studies showing that gut microbiota plays a role in its development - some bacteria promote lesion growth while others produce short-chain fatty acids to counteract it. Treatment with n-butyrate has been found to reduce the growth of lesions in both mouse and human endometriosis cases, offering potential for future diagnostic tests and treatment strategies.
LIFE SCIENCE ALLIANCE
(2021)
Review
Endocrinology & Metabolism
Sangappa B. Chadchan, Vertika Singh, Ramakrishna Kommagani
Summary: This review provides an updated overview of the relationship between the gut microbiome and female reproductive diseases. Recent studies have revealed associations between altered gut microbial compositions and gynecological pathologies such as polycystic ovarian syndrome, endometriosis, and endometrial cancer. Future research should focus on determining the molecular mechanisms underlying these associations.
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sangappa B. Chadchan, Sumanta K. Naik, Pooja Popli, Chandni Talwar, Satwikreddy Putluri, Chandrasekhar R. Ambati, Michael A. Lint, Andrew L. Kau, Christina L. Stallings, Ramakrishna Kommagani
Summary: Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites. Current methods for detecting endometriosis are invasive and ineffective in preventing recurrences. The causal role of gut microbiota and microbiota-derived metabolites in endometriosis progression is largely unknown.
CELL DEATH DISCOVERY
(2023)